Non-Detection of Human Herpesvirus 8 (HHV-8) DNA in HHV-8-Seropositive Blood Donors from Three Brazilian Regions


Levi, JE; Nascimento, MC; Sumita, LM; de Souza, V; Freire, WS; Mayaud, P; Pannuti, CS; (2011) Non-Detection of Human Herpesvirus 8 (HHV-8) DNA in HHV-8-Seropositive Blood Donors from Three Brazilian Regions. PLoS One, 6 (8). ISSN 1932-6203

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Abstract

Human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV), is the etiologic agent of all forms of Kaposi's sarcoma, primary effusion lymphoma and the plasmablastic cell variant of multicentric Castleman disease. In endemic areas of sub-Saharan Africa, blood transfusions have been associated with a substantial risk of HHV-8 transmission. By contrast, several studies among healthy blood donors from North America have failed to detect HHV-8 DNA in samples of seropositive individuals. In this study, using a real-time PCR assay, we investigated the presence of HHV-8 DNA in whole-blood samples of 803 HHV-8 blood donors from three Brazilian states (Sao Paulo, Amazon, Bahia) who tested positive for HHV-8 antibodies, in a previous multicenter study. HHV-8 DNA was not detected in any sample. Our findings do not support the introduction of routine HHV-8 screening among healthy blood donors in Brazil. (WC = 140).

Item Type: Article
Keywords: human-herpesvirus type-8, latent class analysis, kaposis-sarcoma, mononuclear-cells, risk-factors, viral load, transmission, transfusion, prevalence, infection, Adult, Behavior, Brazil, epidemiology, Cervical Intraepithelial Neoplasia, complications, epidemiology, pathology, virology, Colposcopy, Demography, Female, HIV Infections, complications, pathology, Humans, Prevalence, Reproducibility of Results
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Web of Science ID: 293773300032
URI: http://researchonline.lshtm.ac.uk/id/eprint/132

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