Persistence of Vaccine-Induced Measles Antibody Beyond Age 12 Months: A Comparison of Response to One and Two Doses of Edmonston-Zagreb Measles Vaccine Among HIV-Infected and Uninfected Children in Malawi


Fowlkes, A; Witte, D; Beeler, J; Audet, S; Garcia, P; Curns, A; Yang, CF; Fudzulani, R; Broadhead, R; Bellini, WJ; Cutts, F; Helfand, RF; (2011) Persistence of Vaccine-Induced Measles Antibody Beyond Age 12 Months: A Comparison of Response to One and Two Doses of Edmonston-Zagreb Measles Vaccine Among HIV-Infected and Uninfected Children in Malawi. The Journal of infectious diseases, 204. S149-S157. ISSN 0022-1899 DOI: 10.1093/infdis/jir135

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Abstract

Background. Previously, we demonstrated that measles antibody prevalence was lower at age 12 months among children infected with human immunodeficiency virus (HIV) than uninfected children following measles vaccination (MV) at ages 6 and 9 months. Among HIV-uninfected children, measles antibody prevalence was lower among 1- than 2-dose MV recipients. Here, we report results through age 24 months. Methods. Children born to HIV-infected mothers received MV at 6 and 9 months, and children of HIV-uninfected mothers were randomized to MV at 6 and 9 months or MV at 9 months. We followed children through age 24 months. The child's HIV status was determined and measles immunoglobulin G (IgG) level was measured by enzyme immunoassay (PIA) and by plaque reduction neutralization (PRN) on a subset. Results. Among HIV-uninfected children, the difference in measles antibody prevalence at age 12 months between one- and two-dose recipients reported previously by EIA was shown to be smaller by PRN. By age 24 months, 84% and 87% of HIV-uninfected children receiving 1 or 2 doses, respectively, were seroprotected. Only 41% of 22 HIV-infected children were measles seroprotected at age 20 months. Discussion. Measles seroprotection persisted through age 24 months among HIV-uninfected children who received 1 or 2 doses of MV. HIV-infected children demonstrated seroprotection through age 12 months, but this was not sustained.

Item Type: Article
Keywords: zambian children, 6-month-old infants, neutralization test, placental-transfer, immunogenicity, immunization, immunity, mothers, strain, titers, en rt, 1990, v162, p1036, Antibodies, Viral, blood, Dose-Response Relationship, Immunologic, Drug Administration Schedule, Female, HIV Infections, complications, epidemiology, immunology, Humans, Immunocompromised Host, Immunoenzyme Techniques, Infant, Malawi, epidemiology, Male, Measles, prevention & control, Measles Vaccine, administration & dosage, immunology, Measles virus, immunology, Neutralization Tests
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Vaccine Centre
PubMed ID: 21666156
Web of Science ID: 293547600020
URI: http://researchonline.lshtm.ac.uk/id/eprint/130

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