The incidence and aetiology of stroke in the Caerphilly and Speedwell Collaborative Studies II: risk factors for ischaemic stroke


McCarron, P; Greenwood, R; Elwood, P; Shlomo, YB; Bayer, A; Baker, I; Frankel, S; Ebrahim, S; Murray, L; Smith, GD; (2001) The incidence and aetiology of stroke in the Caerphilly and Speedwell Collaborative Studies II: risk factors for ischaemic stroke. Public health, 115 (1). pp. 12-20. ISSN 0033-3506 DOI: https://doi.org/10.1038/sj.ph.1900724

Full text not available from this repository.

Abstract

Reduction of stroke burden requires preventive interventions targeted at important risk factors. This report presents the analysis of risk factors for ischaemic stroke from a representative cohort of middle aged men from South Wales and south-west England. Data on risk factors were collected through validated questionnaires and physical and clinical measurements. Details of possible cerebrovascular events were retrieved, classified into ischaemic, haemorrhagic and uncertain subtypes, and validated. The ratio of definite ischaemic to definite haemorrhagic strokes was calculated. This showed that the vast majority of strokes of unknown subtype were likely to ischaemic. After exclusion of known haemorrhagic strokes and subarrachnoid haemorrhages the remaining strokes were labelled ischaemic. Hazard ratios for possible risk factors were calculated for all ischaemic, and for fatal and non-fatal strokes. There were 293 ischaemic strokes. Statistically significant age-adjusted hazard ratios were: 1.50 (95% confidence interval 1.16-1.95) for being in a manual social class, 1.82 (1.24-2.67) if smoking >15 cigarettes/d at enrollment, 1.19 (1.13-1.24) and 1.23 (1.14-1.34) per 10 mmHg increase in systolic and diastolic blood pressure, respectively, 0.67 (0.46-0.96) for the top quintile high density lipoprotein-cholesterol:cholesterol ratio compared to the bottom quintile, 2.04 (1.40-2.99) for presence of angina, 3.90 (2.01-7.58) for presence of atrial fibrillation, and 3.35 (1.90-5.80) for presence of diabetes. Risk factors were more strongly associated with fatal than non-fatal strokes. Multivariate analyses revealed that, while there was some attenuation of the effect of social class, angina and elevated BP, the risks from atrial fibrillation and diabetes were increased.

Item Type: Article
Keywords: Brain Ischemia/*complications, Cerebrovascular Accident/classification/diagnosis/*epidemiology/*etiology, Cohort Studies, Comparative Study, England/epidemiology, Humans, Male, Middle Aged, Multivariate Analysis, Research Support, Non-U.S. Gov't, Risk Factors, State Medicine, Wales/epidemiology, Brain Ischemia, complications, Cerebrovascular Accident, classification, diagnosis, epidemiology, etiology, Cohort Studies, Comparative Study, England, epidemiology, Humans, Male, Middle Aged, Multivariate Analysis, Research Support, Non-U.S. Gov't, Risk Factors, State Medicine, Wales, epidemiology
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 11402347
Web of Science ID: 167124900004
URI: http://researchonline.lshtm.ac.uk/id/eprint/12626

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
316Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item