Conjugate pneumococcal vaccine in HIV-infected Ugandans and the effect of past receipt of polysaccharide vaccine


Miiro, G; Kayhty, H; Watera, C; Tolmie, H; Whitworth, JAG; Gilks, CF; French, N; (2005) Conjugate pneumococcal vaccine in HIV-infected Ugandans and the effect of past receipt of polysaccharide vaccine. The Journal of infectious diseases, 192 (10). pp. 1801-1805. ISSN 0022-1899 DOI: 10.1086/497144

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Abstract

We investigated the immunogenicity of a 7-valent conjugate pneumococcal vaccine (CPV) in human immunodeficiency virus - infected Ugandan adults and measured the effect of past pneumococcal polysaccharide vaccine (PPV) receipt given as part of a controlled trial. Two doses of CPV, 4 weeks apart, were given to 54 past PPV recipients and 55 past placebo recipients (84% female; median CD4 cell count, 251 cells/mu L [range, 1 - 936 cells/mu L]). Postvaccination anticapsular immunoglobulin G (IgG) concentrations were directly correlated with CD4 cell count (P < .01 for all serotypes). There were significant increases in anticapsular IgG concentrations for all serotypes after the first dose (P < .01) and for all serotypes except 14 and 9V after the second dose. Past receipt of PPV did not affect vaccine response.

Item Type: Article
Keywords: Immunodeficiency-virus type-1, antibody-response, randomized trial, adults, disease, immunogenicity, children, cohort, impact
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Vaccine Centre
PubMed ID: 16235180
Web of Science ID: 232702000019
URI: http://researchonline.lshtm.ac.uk/id/eprint/12399

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