CD11b Regulates Recruitment of Alveolar Macrophages but Not Pulmonary Dendritic Cells after Pneumococcal Challenge.


Kirby, AC; Raynes, JG; Kaye, PM; (2006) CD11b Regulates Recruitment of Alveolar Macrophages but Not Pulmonary Dendritic Cells after Pneumococcal Challenge. The Journal of infectious diseases, 193 (2). pp. 205-13. ISSN 0022-1899 DOI: https://doi.org/10.1086/498874

Full text not available from this repository.

Abstract

Despite their close physical and functional relationships, alveolar macrophages (AMs) and pulmonary dendritic cells (pulDCs) have rarely been examined together in the context of infection. Using a nonlethal, resolving model of pneumonia caused by intranasal injection of Streptococcus pneumoniae, we demonstrate that AMs and pulDCs exhibit distinct characteristics during pulmonary inflammation. Recruitment of AMs and pulDCs occurred with different kinetics, and increased numbers of AMs resulted mainly from the appearance of a distinct subset of CD11b(High) AMs. Increased numbers of CD11b(High) and CD11b(Low) AMs, but not pulDCs, were recoverable from bronchoalveolar lavage fluid. CD11b expression on AMs was significantly increased by granulocyte-macrophage colony-stimulating factor but not by interleukin-10 or pathogen-associated stimuli. Finally, antibody blockade demonstrated that CD11b was critical for the recruitment of AMs, but not pulDCs, into the lung after pneumococcal challenge. These data demonstrate that there are significant differences between AM and pulDC responses to inflammatory pathogenic stimuli in vivo.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
PubMed ID: 16362884
Web of Science ID: 234183200006
URI: http://researchonline.lshtm.ac.uk/id/eprint/12358

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
308Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item