Meningococcal carriage in the African meningitis belt


Ali, O; Aseffa, A; Bedru, A; Lemma, T; Moti, T; Worku, A; Xabher, HG; Yamuah, L; Boukary, RM; Collard, JM; Dano, ID; Habiboulaye, I; Issaka, B; Jusot, JF; Ousmane, S; Rabe, I; Clark, T; Mayer, L; Gami, JP; Gamougam, K; Kodbesse, B; Naibei, N; Ngadoua, C; Mbainadji, L; Moto, DD; Narbe, M; Toralta, J; Berthe, A; Keita, M; Diallo, K; Onwuchekwa, U; Sow, SO; Tamboura, B; Traore, A; Toure, A; Amodu, M; Beida, O; Gadzama, G; Omotara, B; Sambo, Z; Yahya, S; Chandramohan, D; Greenwood, B; Hassan-King, M; Manigart, O; Nascimento, M; Stuart, J; Woukeu, A; Bai, XL; Borrow, R; Findlow, H; Avalo, S; Bassene, H; Diallo, A; Dieng, M; Doucoure, S; Gomis, JF; Ndiaye, A; Sokhna, C; Trape, JF; Akalifa, B; Forgor, A; Hodgson, A; Osei, I; Quaye, S; Williams, J; Wontuo, P; Basta, N; Irving, T; Trotter, C; Bennett, J; Dieng, M; Hill, D; Harrison, O; Rebbetts, L; Maiden, M; Tekletsion, Y; Watkins, E; Menafricar, Consortium; African, Partners; Northern, Partners; (2013) Meningococcal carriage in the African meningitis belt. Tropical medicine & international health, 18 (8). pp. 968-978. ISSN 1360-2276 DOI: https://doi.org/10.1111/tmi.12125

[img]
Preview
Text - Published Version
License: Copyright the author(s)

Download (272kB) | Preview

Abstract

A meningococcal serogroup A polysaccharide/tetanus toxoid conjugate vaccine (PsA-TT) (MenAfriVac) is being deployed in countries of the African meningitis belt. Experience with other polysaccharide/protein conjugate vaccines has shown that an important part of their success has been their ability to prevent the acquisition of pharyngeal carriage and hence to stop transmission and induce herd immunity. If PsA-TT is to achieve the goal of preventing epidemics, it must be able to prevent the acquisition of pharyngeal carriage as well as invasive meningococcal disease and whether PsA-TT can prevent pharyngeal carriage needs to be determined. To address this issue, a consortium (the African Meningococcal Carriage (MenAfriCar) consortium) was established in 2009 to investigate the pattern of meningococcal carriage in countries of the African meningitis belt prior to and after the introduction of PsA-TT. This article describes how the consortium was established, its objectives and the standardised field and laboratory methods that were used to achieve these objectives. The experience of the MenAfriCar consortium will help in planning future studies on the epidemiology of meningococcal carriage in countries of the African meningitis belt and elsewhere.

Item Type: Article
Keywords: Africa, MenAfriCar, meningococcal carriage, meningococcal vaccines, meningococcus, Neisseria meningitidis, conjugate vaccine, neisseria-meningitidis, burkina-faso, serogroup-a, identification, epidemiology, antibody, impact, Adolescent, Adult, Africa, epidemiology, Carrier State, epidemiology, microbiology, Child, Child, Preschool, Cross-Sectional Studies, Enzyme-Linked Immunosorbent Assay, Epidemics, prevention & control, Humans, Immunization Programs, Infant, International Cooperation, Meningitis, Meningococcal, epidemiology, immunology, prevention & control, Meningococcal Vaccines, immunology, therapeutic use, Neisseria meningitidis, Serogroup A, immunology, isolation & purification, Pharynx, microbiology, Pilot Projects, Polymerase Chain Reaction, Program Evaluation, methods, Specimen Handling, methods, Vaccines, Conjugate, Young Adult
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) > Dept of Population Studies (1974-2012)
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
Research Centre: Centre for Maternal, Reproductive and Child Health (MARCH)
PubMed ID: 23682910
Web of Science ID: 321504000008
URI: http://researchonline.lshtm.ac.uk/id/eprint/1229422

Statistics


Download activity - last 12 months
Downloads since deposit
673Downloads
394Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item