Cohort Profile: Andhra Pradesh Children and Parents Study (APCAPS).


Kinra, S; Radha Krishna, KV; Kuper, H; Rameshwar Sarma, KV; Prabhakaran, P; Gupta, V; Walia, GK; Bhogadi, S; Kulkarni, B; Kumar, A; Aggarwal, A; Gupta, R; Prabhakaran, D; Reddy, KS; Smith, GD; Ben-Shlomo, Y; Ebrahim, S; (2014) Cohort Profile: Andhra Pradesh Children and Parents Study (APCAPS). International journal of epidemiology, 43 (5). pp. 1417-24. ISSN 0300-5771 DOI: 10.1093/ije/dyt128

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Abstract

: The Andhra Pradesh Children and Parents Study (APCAPS) was originally established to study the long-term effects of early-life undernutrition on risk of cardiovascular disease. Its aims were subsequently expanded to include trans-generational influences of other environmental and genetic factors on chronic diseases in rural India. It builds on the Hyderabad Nutrition Trial (HNT) conducted in 1987-90 to compare the effects on birthweight of a protein-calorie supplement for pregnant women and children. The index children of HNT and their mothers were retraced and examined in 2003-05, and the children re-examined as young adults aged 18-21 years in 2009-10. The cohort was expanded to include both parents and siblings of the index children in a recently completed follow-up conducted in 2010-12 (N=∼6225 out of 10,213 participants). Recruitment of the remaining residents of these 29 villages (N=∼55,000) in Ranga Reddy district of Andhra Pradesh is now under way. Extensive data on socio-demographic, lifestyle, medical, anthropometric, physiological, vascular and body composition measures, DNA, stored plasma, and assays of lipids and inflammatory markers on APCAPS participants are available. Details of how to access these data are available from the corresponding author.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Research Centre: The International Centre for Evidence in Disability
Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 24019421
Web of Science ID: 343972200012
URI: http://researchonline.lshtm.ac.uk/id/eprint/1194232

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