Occurrence of the southeast Asian/south American SVMNT haplotype of the chloroquine-resistance transporter gene in Plasmodium falciparum in Tanzania


Alifrangis, M; Dalgaard, MB; Lusingu, JP; Vestergaard, LS; Staalsoe, T; Jensen, ATR; Enevold, A; Ronn, AM; Khalil, IF; Warhurst, DC; Lemnge, MM; Theander, TG; Bygbjerg, IC; (2006) Occurrence of the southeast Asian/south American SVMNT haplotype of the chloroquine-resistance transporter gene in Plasmodium falciparum in Tanzania. The Journal of infectious diseases, 193 (12). pp. 1738-1741. ISSN 0022-1899 DOI: 10.1086/504269

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Abstract

Two main haplotypes, CVIET and SVMNT, of the Plasmodium falciparum chloroquine-resistance transporter gene (Pfcrt) are linked to 4-aminoquinoline resistance. The CVIET haplotype has been reported in most malaria-endemic regions, whereas the SVMNT haplotype has only been found outside Africa. We investigated Pfcrt haplotype frequencies in Korogwe District, Tanzania, in 2003 and 2004. The SVMNT haplotype was not detected in 2003 but was found in 19% of infected individuals in 2004. Amodiaquine use has increased in the region. The introduction and high prevalence of the SVMNT haplotype may reflect this and may raise concern regarding the use of amodiaquine in artemisinin-based combination therapies in Africa.

Item Type: Article
Keywords: Malaria, pfcrt, amodiaquine, mutations, sensitivity, parasites, immunity
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Research Centre: Antimicrobial Resistance Centre (AMR)
Malaria Centre
PubMed ID: 16703518
Web of Science ID: 237553400017
URI: http://researchonline.lshtm.ac.uk/id/eprint/11818

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