The analysis of longitudinal data using mixed model L-splines

Welham, SJ; Cullis, BR; Kenward, MG; Thompson, R; (2006) The analysis of longitudinal data using mixed model L-splines. Biometrics, 62 (2). pp. 392-401. ISSN 0006-341X DOI:

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L-splines area large family of smoothing splines defined in terms of a linear differential operator. This article develops L-splines within the context of linear mixed models and uses the resulting mixed model L-spline to analyze longitudinal data from a grassland experiment. In the spirit of time-series analysis, a periodic mixed model L-spline is developed, which partitions data into a smooth periodic component plus smooth long-term trend.

Item Type: Article
Keywords: longitudinal data, L-splines, mixed models, residual maximum, likelihood, smoothing splines, Penalized splines, variance, regression, penalties
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
PubMed ID: 16918903
Web of Science ID: 238384500008


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