The epidemiology of Plasmodium falciparum gametocytes: weapons of mass dispersion.


Drakeley, C; Sutherland, C; Bousema, JT; Sauerwein, RW; Targett, GA; (2006) The epidemiology of Plasmodium falciparum gametocytes: weapons of mass dispersion. Trends in parasitology, 22 (9). pp. 424-30. ISSN 1471-4922 DOI: https://doi.org/10.1016/j.pt.2006.07.001

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Abstract

Much of the epidemiology of Plasmodium falciparum in Sub-Saharan Africa focuses on the prevalence patterns of asexual parasites in people of different ages, whereas the gametocytes that propagate the disease are often neglected. One expected benefit of the widespread introduction of artemisinin-based combination therapy for malaria is a reduction in gametocyte carriage. However, the factors that affect the transmission of parasites from humans to mosquitoes show complex dynamics in relation to the intensity and seasonality of malaria transmission, and thus such benefits might not be automatic. Here, we review data on gametocyte carriage in the context of the development of naturally acquired immunity and population infectivity.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Malaria Centre
PubMed ID: 16846756
Web of Science ID: 240375500006
URI: http://researchonline.lshtm.ac.uk/id/eprint/11708

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