Amyloid load and cerebral atrophy in Alzheimer's disease: An C-11-PIB positron emission tomography study


Archer, HA; Edison, P; Brooks, DJ; Barnes, J; Frost, C; Yeatman, T; Fox, NC; Rossor, MN; (2006) Amyloid load and cerebral atrophy in Alzheimer's disease: An C-11-PIB positron emission tomography study. Annals of neurology, 60 (1). pp. 145-147. ISSN 0364-5134 DOI: https://doi.org/10.1002/ana.20889

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Abstract

To determine the relationship between cerebral amyloid plaque load and rates of cerebral atrophy in Alzheimer's disease. C-11-PIB(C-11-6-OH benzothiazole)PET (positron emission tomography) findings were correlated with volumetric magnetic resonance imaging (MRI) measurements in nine subjects with mild to moderate AD. Analysis revealed a positive correlation between rates of whole brain atrophy and whole brain (p = 0.019) and regional C-11-PIB uptake. This provides support for the central role of amyloid deposition in the pathogenesis of AD.

Item Type: Article
Keywords: Brain atrophy, serial mri, volume, validation, dementia
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
PubMed ID: 16802294
Web of Science ID: 238825500021
URI: http://researchonline.lshtm.ac.uk/id/eprint/11624

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