Very large long-term effective population size in the virulent human malaria parasite Plasmodium falciparum.


Hughes, AL; Verra, F; (2001) Very large long-term effective population size in the virulent human malaria parasite Plasmodium falciparum. Proceedings Biological sciences / The Royal Society, 268 (1478). pp. 1855-60. ISSN 0962-8452 DOI: https://doi.org/10.1098/rspb.2001.1759

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Abstract

It has been proposed that the virulent human malaria parasite Plasmodium falciparum underwent a recent severe population bottleneck. In order to test this hypothesis, we estimated the effective population size of this species from the patterns of nucleotide substitution at 23 nuclear protein-coding loci, using a variety of methods based on coalescent theory. Both simple methods and phylogenetically based maximum-likelihood methods yielded the conclusion that the effective population size of this species has been of the order of at least 10(5) for the past 300,000-400,000 years.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Research Centre: Malaria Centre
PubMed ID: 11522206
Web of Science ID: 170834600015
URI: http://researchonline.lshtm.ac.uk/id/eprint/11406

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