Increased rate of whole-brain atrophy over 6 months in early Huntington's disease.


Henley, SM; Frost, C; MacManus, DG; Warner, TT; Fox, NC; Tabrizi, SJ; (2006) Increased rate of whole-brain atrophy over 6 months in early Huntington's disease. Neurology, 67 (4). pp. 694-6. ISSN 0028-3878 DOI: https://doi.org/10.1212/01.wnl.0000230149.36635.c8

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Abstract

The authors measured the rate of whole-brain atrophy over 6 months in 13 patients with early Huntington disease (HD) and seven matched controls. Patients with early HD had significantly increased rates of whole-brain atrophy vs controls (mean [SD] HD, 1.10 [0.88]%/year; controls, 0.26 [0.54]%/year). The measurement of cerebral change over short time periods (e.g., 6 months) may be relevant for trials designed to assess effects on neurodegeneration or atrophy.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
PubMed ID: 16924028
Web of Science ID: 239920100033
URI: http://researchonline.lshtm.ac.uk/id/eprint/11232

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