Influenza, Campylobacter and Mycoplasma Infections, and Hospital Admissions for Guillain-BarrE Syndrome, England.


Tam, CC; O'Brien, SJ; Rodrigues, LC; (2006) Influenza, Campylobacter and Mycoplasma Infections, and Hospital Admissions for Guillain-BarrE Syndrome, England. Emerging infectious diseases, 12 (12). pp. 1880-7. ISSN 1080-6040 DOI: https://doi.org/10.3201/eid1212.051032

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Abstract

: Guillain-Barré syndrome (GBS) is the most common cause of acute flaccid paralysis in polio-free regions. Considerable evidence links Campylobacter infection with GBS, but evidence that implicates other pathogens as triggers remains scarce. We conducted a time-series analysis to investigate short-term correlations between weekly laboratory-confirmed reports of putative triggering pathogens and weekly hospitalizations for GBS in England from 1993 through 2002. We found a positive association between the numbers of reports of laboratory-confirmed influenza A in any given week and GBS hospitalizations in the same week. Different pathogens may trigger GBS in persons of different ages; among those <35 years, numbers of weekly GBS hospitalizations were associated with weekly Campylobacter and Mycoplasma pneumoniae reports, whereas among those >35 years, positive associations were with influenza. Further studies should estimate the relative contribution of different pathogens to GBS incidence, overall and by age group, and determine whether influenza is a real trigger for GBS or a marker for influenza vaccination.<br/>

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 17326939
Web of Science ID: 242301900012
URI: http://researchonline.lshtm.ac.uk/id/eprint/10347

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