The malaria and typhoid fever burden in the slums of Kolkata, India: data from a prospective community-based study


Sur, D; von Seidlein, L; Manna, B; Dutta, S; Deb, AK; Sarkar, BL; Kanungo, S; Deen, JL; Ali, M; Kim, DR; Gupta, VK; Ochiai, RL; Tsuzuki, A; Acosta, CJ; Clemens, JD; Bhattacharya, SK; (2006) The malaria and typhoid fever burden in the slums of Kolkata, India: data from a prospective community-based study. Transactions of the Royal Society of Tropical Medicine and Hygiene, 100 (8). pp. 725-33. ISSN 0035-9203 DOI: 10.1016/j.trstmh.2005.10.019

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Abstract

Recent research has indicated that the malaria burden in Asia may have been vastly underestimated. We conducted a prospective community-based study in an impoverished urban site in Kolkata, India, to estimate the burden of malaria and typhoid fever and to identify risk factors for these diseases. In a population of 60452 people, 3605 fever episodes were detected over a 12-month period. The blood films of 93 febrile patients contained Plasmodium (90 P. vivax, 2 P. falciparum and 1 P. malariae). Blood cultures from 95 patients grew Salmonella enterica serotype Typhi. Malaria patients were found to be significantly older (mean age 29 years) compared with patients with typhoid fever (15 years; P<0.001) but had similar clinical features on presentation. Having a household member with malaria, illiteracy, low household income and living in a structure not built of bricks were associated with an increased risk for malaria. Having a household member with typhoid fever and poor hygiene were associated with typhoid fever. A geographic analysis of the spatial distribution of malaria and typhoid fever cases detected high-risk neighbourhoods for each disease. Focal interventions to minimise human-vector contact and improved personal hygiene and targeted vaccination campaigns could help to prevent malaria and typhoid fever in this site.

Item Type: Article
Keywords: Adolescent, Adult, Aged, Child, Child, Preschool, Female, Humans, India/epidemiology, Infant, Malaria/*epidemiology, Male, Middle Aged, Poverty Areas, Prospective Studies, Residence Characteristics, Risk Factors, Typhoid Fever/*epidemiology, Urban Health, Adolescent, Adult, Aged, Child, Child, Preschool, Female, Humans, India, epidemiology, Infant, Malaria, epidemiology, Male, Middle Aged, Poverty Areas, Prospective Studies, Residence Characteristics, Risk Factors, Typhoid Fever, epidemiology, Urban Health
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
PubMed ID: 16455118
Web of Science ID: 239270400004
URI: http://researchonline.lshtm.ac.uk/id/eprint/10275

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