Occurrence of shigellosis in the young and elderly in rural China: results of a 12-month population-based surveillance study


Wang, XY; du, L; von Seidlein, L; Xu, ZY; Zhang, YL; Hao, ZY; Han, OP; Ma, JC; Lee, HJ; Ali, M; Han, CQ; Xing, ZC; Chen, JC; Clemens, J; (2005) Occurrence of shigellosis in the young and elderly in rural China: results of a 12-month population-based surveillance study. The American journal of tropical medicine and hygiene, 73 (2). pp. 416-22. ISSN 0002-9637

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Abstract

In 2002, population- and treatment center-based surveillance was used to study the disease burden of shigellosis in rural Hebei Province in the People's Republic of China. A total of 10,105 children with diarrhea or dysentery were enrolled. Infants were treated most frequently for diarrhea (1,388/1,000/year) followed by children < or = 5 years old (618/1,000/year). Shigellosis was treated most often in children 3-4 years old (32/1,000/year) and people > 60 years of age (7/1,000/year). Fifty-six percent (184 of 331) Shigella isolates were detected in patients who had non-bloody diarrhea. Shigella flexneri was identified in 93% of 306 isolates. The most common S. flexneri serotypes were 1a (34%), X (33%), and 2a (28%). More than 90% of the Shigella isolates were resistant to cotrimoxazole and nalidixic acid, but remained susceptible to ciprofloxacin, norfloxacin, and gentamicin. Widespread resistance to antibiotics adds urgency to the development and use of vaccines to control shigellosis.

Item Type: Article
Keywords: Adolescent, Age Distribution, Aged, Anti-Bacterial Agents/pharmacology, Child, Child, Preschool, China, Diarrhea/epidemiology/microbiology/physiopathology, Dysentery, Bacillary/*epidemiology/microbiology/physiopathology, Humans, Infant, Microbial Sensitivity Tests, Middle Aged, *Population Surveillance, *Rural Population, Seasons, Shigella/classification/drug effects/isolation & purification, Shigella flexneri/drug effects/isolation & purification, Adolescent, Age Distribution, Aged, Anti-Bacterial Agents, pharmacology, Child, Child, Preschool, China, Diarrhea, epidemiology, microbiology, physiopathology, Dysentery, Bacillary, epidemiology, microbiology, physiopathology, Humans, Infant, Microbial Sensitivity Tests, Middle Aged, Population Surveillance, Rural Population, Seasons, Shigella, classification, drug effects, isolation & purification, Shigella flexneri, drug effects, isolation & purification
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
PubMed ID: 16103614
Web of Science ID: 231272700036
URI: http://researchonline.lshtm.ac.uk/id/eprint/10263

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