Serum perfluoroalkyl acids concentrations and memory impairment in a large cross-sectional study.


Gallo, V; Leonardi, G; Brayne, C; Armstrong, B; Fletcher, T; (2013) Serum perfluoroalkyl acids concentrations and memory impairment in a large cross-sectional study. BMJ Open, 3 (6). ISSN 2044-6055 DOI: https://doi.org/10.1136/bmjopen-2012-002414

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Abstract

OBJECTIVES To examine the cross-sectional association between serum perfluorooctanate (PFOA), perfuorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA) and perfluorohexane sulfonate (PFHxS) concentrations with self-reported memory impairment in adults and the interaction of these associations with diabetes status. DESIGN Cross-sectional study. SETTING Population-based in Mid-Ohio Valley, West Virginia following contamination by a chemical plant. PARTICIPANTS The C8 Health Project collected data and measured the serum level of perfluoroalkyl acids (PFAAs) of 21 024 adults aged 50+ years. PRIMARY OUTCOME MEASURE Self-reported memory impairment as defined by the question 'have experienced short-term memory loss?' RESULTS A total of 4057 participants self-reported short-term memory impairment. Inverse associations between PFOS and PFOA and memory impairment were highly statistically significant with fully adjusted OR=0.93 (95% CI 0.90 to 0.96) for doubling PFOS and OR=0.96 (95% CI 0.94 to 0.98) for doubling PFOA concentrations. Comparable inverse associations with PFNA and PFHxS were of borderline statistical significance. Inverse associations of PFAAs with memory impairment were weaker or non-existent in patients with diabetes than overall in patients without diabetes. CONCLUSIONS An inverse association between PFAA serum levels and self-reported memory impairment has been observed in this large population-based, cross-sectional study that is stronger and more statistically significant for PFOA and PFOS. The associations can be potentially explained by a preventive anti-inflammatory effect exerted by a peroxisome proliferator-activated receptor agonist effect of these PFAAs, but confounding or even reverse causation cannot be excluded as an alternative explanation.

Item Type: Article
Faculty and Department: Faculty of Public Health and Policy > Dept of Social and Environmental Health Research
PubMed ID: 23794579
Web of Science ID: 330561600005
URI: http://researchonline.lshtm.ac.uk/id/eprint/1012266

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