Chang, Irene; Thomas, Karen; O'Neill Gutierrez, Lauran; Peters, Sam; Agbeko, Rachel; Au, Carly; Draper, Elizabeth; Jones, Gareth AL; Major, Lee Elliot; Orzol, Marzena; +9 more... Pappachan, John; Ramnarayan, Padmanabhan; Ray, Samiran; Sadique, Zia; Gould, Doug W; Harrison, David A; Rowan, Kathryn M; Mouncey, Paul R; Peters, Mark J; (2022) Protocol for a Randomized Multiple Center Trial of Conservative Versus Liberal Oxygenation Targets in Critically Ill Children (Oxy-PICU): Oxygen in Pediatric Intensive Care. Pediatric Critical Care Medicine, 23 (9). pp. 736-744. ISSN 1529-7535 DOI: https://doi.org/10.1097/PCC.0000000000003008

King, Jessica; Sadique, Zia; Amara, Michael; Borghi, Josephine; (2022) Has Ebola delayed progress on access to routine care and financial protection in Sierra Leone? Evidence from a difference-in-differences analysis with propensity score weighting. Social science & medicine (1982), 303. 114995-. ISSN 0277-9536 DOI: https://doi.org/10.1016/j.socscimed.2022.114995

Sadique, Zia; Cairns, John; De Corte, Kaat; Willis, Sarah; Miners, Alec; Bansback, Nick; Grieve, Richard; (2022) A Comparison of Ordered Categorical versus Discrete Choices within a Stated Preference Survey of Whole-Blood Donors. Medical Decision Making, 43 (3). pp. 362-373. ISSN 0272-989X DOI: https://doi.org/10.1177/0272989X221145048

Sadique, Zia; Grieve, Richard; Diaz-Ordaz, Karla; Mouncey, Paul; Lamontagne, Francois; O'Neill, Stephen; (2022) A Machine-Learning Approach for Estimating Subgroup- and Individual-Level Treatment Effects: An Illustration Using the 65 Trial. Medical decision making : an international journal of the Society for Medical Decision Making, 42 (7). pp. 923-936. ISSN 0272-989X DOI: https://doi.org/10.1177/0272989X221100717

Sadique, Zia; Willis, Sarah; Corte, Kaat De; Pennington, Mark; Moore, Carmel; Kaptoge, Stephen; Angelantonio, Emanuele Di; Miflin, Gail; Roberts, David J; Grieve, Richard; (2022) Cost-effectiveness of alternative minimum recall intervals between whole blood donations. PloS One, 17 (8). e0272854-. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0272854

Sun, Li; Cui, Bin; Wei, Xia; Sadique, Zia; Yang, Li; Manchanda, Ranjit; Legood, Rosa; (2022) Cost-Effectiveness of Genetic Testing for All Women Diagnosed with Breast Cancer in China. CANCERS, 14 (7). p. 1839. ISSN 2072-6694 DOI: https://doi.org/10.3390/cancers14071839

Kiguli, Sarah; Olopot-Olupot, Peter; Alaroker, Florence; Engoru, Charles; Opoka, Robert O; Tagoola, Abner; Hamaluba, Mainga; Mnjalla, Hellen; Mpoya, Ayub; Mogaka, Christabel; +13 more... Nalwanga, Damalie; Nabawanuka, Eva; Nokes, James; Nyaigoti, Charles; Briend, André; van Woensel, Job BM; Grieve, Richard; Sadique, Zia; Williams, Thomas N; Thomas, Karen; Harrison, David A; Rowan, Kathryn; Maitland, Kathryn; (2021) Children's Oxygen Administration Strategies And Nutrition Trial (COAST-Nutrition): a protocol for a phase II randomised controlled trial. Wellcome open research, 6. 221-. ISSN 2398-502X DOI: https://doi.org/10.12688/wellcomeopenres.17123.2

Ansbro, Éimhín; Garry, Sylvia; Karir, Veena; Reddy, Amulya; Jobanputra, Kiran; Fardous, Taissir; Sadique, Zia; (2020) Delivering a primary-level non-communicable disease programme for Syrian refugees and the host population in Jordan: a descriptive costing study. HEALTH POLICY AND PLANNING, 35 (8). pp. 931-940. ISSN 0268-1080 DOI: https://doi.org/10.1093/heapol/czaa050

Legood, Rosa; Opondo, Charles; Warren, Emily; Jamal, Farah; Bonell, Chris; Viner, Russell; Sadique, Zia; (2020) Cost-Utility Analysis of a Complex Intervention to Reduce School-Based Bullying and Aggression: An Analysis of the Inclusive RCT. Value in Health, 24 (1). pp. 129-135. ISSN 1098-3015 DOI: https://doi.org/10.1016/j.jval.2020.04.1839

Manchanda, Ranjit; Sun, Li; Patel, Shreeya; Evans, Olivia; Wilschut, Janneke; De Freitas Lopes, Ana Carolina; Gaba, Faiza; Brentnall, Adam; Duffy, Stephen; Cui, Bin; +8 more... Coelho De Soarez, Patricia; Husain, Zakir; Hopper, John; Sadique, Zia; Mukhopadhyay, Asima; Yang, Li; Berkhof, Johannes; Legood, Rosa; (2020) Economic Evaluation of Population-Based BRCA1/BRCA2 Mutation Testing across Multiple Countries and Health Systems. CANCERS, 12 (7). p. 1929. ISSN 2072-6694 DOI: https://doi.org/10.3390/cancers12071929

Richards-Belle, Alvin; Davis, Peter; Drikite, Laura; Feltbower, Richard; Grieve, Richard; Harrison, David A; Lester, Julie; Morris, Kevin P; Mouncey, Paul R; Peters, Mark J; +4 more... Rowan, Kathryn M; Sadique, Zia; Tume, Lyvonne N; Ramnarayan, Padmanabhan; (2020) FIRST-line support for assistance in breathing in children (FIRST-ABC): a master protocol of two randomised trials to evaluate the non-inferiority of high-flow nasal cannula (HFNC) versus continuous positive airway pressure (CPAP) for non-invasive respiratory support in paediatric critical care. BMJ OPEN, 10 (8). e038002-. ISSN 2044-6055 DOI: https://doi.org/10.1136/bmjopen-2020-038002

Sun, Li; Cromwell, David; Dodwell, David; Horgan, Kieran; Gannon, Melissa Ruth; Medina, Jibby; Pennington, Mark; Legood, Rosa; Dos-Santos-Silva, Isabel; Sadique, Zia; (2020) Costs of Early Invasive Breast Cancer in England Using National Patient-Level Data. VALUE IN HEALTH, 23 (10). pp. 1316-1323. ISSN 1098-3015 DOI: https://doi.org/10.1016/j.jval.2020.05.013

Tariq, Hisham; Emes, David Tresco; Boo, Yebeen Ysabelle; Light, Alexander; Sadique, Zia; Khan, Mishal; Knight, Alan; Dar, Osman; Manikam, Logan; (2020) Economic impact of Ebola virus disease outbreak on an extractive firm: a case study. UCL open: Environment, 2. e007. ISSN 2632-0886 DOI: https://doi.org/10.14324/111.444/ucloe.000007

Ansbro, Éimhín Mary; Biringanine, Michel; Caleo, Grazia; Prieto-Merino, David; Sadique, Zia; Perel, Pablo; Jobanputra, Kiran; Roberts, Bayard; (2019) Management of diabetes and associated costs in a complex humanitarian setting in the Democratic Republic of Congo: a retrospective cohort study. BMJ open, 9 (11). e030176-. ISSN 2044-6055 DOI: https://doi.org/10.1136/bmjopen-2019-030176

Bonell, Chris; Allen, Elizabeth; Warren, Emily; McGowan, Jennifer; Bevilacqua, Leonardo; Jamal, Farah; Sadique, Zia; Legood, Rosa; Wiggins, Meg; Opondo, Charles; +12 more... Mathiot, Anne; Sturgess, Joanna; Paparini, Sara; Fletcher, Adam; Perry, Miranda; West, Grace; Tancred, Tara; Scott, Stephen; Elbourne, Diana; Christie, Deborah; Bond, Lyndal; Viner, Russell M; (2019) Modifying the secondary school environment to reduce bullying and aggression: the INCLUSIVE cluster RCT. Public Health Research, 7 (18). pp. 1-164. ISSN 2050-4381 DOI: https://doi.org/10.3310/phr07180

Makhani, Lizna A; Moran, Valerie; Sadique, Zia; Singh, Neha S; Revill, Paul; Roberts, Bayard; (2019) Examining the use of economic evaluations in health-related humanitarian programmes in low- and middle-income countries: a systematic review. Health policy and planning, 35 (2). pp. 210-218. ISSN 0268-1080 DOI: https://doi.org/10.1093/heapol/czz144

Mouncey, Paul R; Wade, Dorothy; Richards-Belle, Alvin; Sadique, Zia; Wulff, Jerome; Grieve, Richard; Emerson, Lydia M; Brewin, Chris R; Harvey, Sheila; Howell, David; +8 more... Hudson, Nicholas; Khan, Imran; Mythen, Monty; Smyth, Deborah; Weinman, John; Welch, John; Harrison, David A; Rowan, Kathryn M; (2019) A nurse-led, preventive, psychological intervention to reduce PTSD symptom severity in critically ill patients: the POPPI feasibility study and cluster RCT. Health Services and Delivery Research, 7 (30). pp. 1-174. ISSN 2050-4349 DOI: https://doi.org/10.3310/hsdr07300

Sun, Li; (2019) Economics of Breast Cancer Screening, Genetic Testing, and Treatment. PhD (research paper style) thesis, London School of Hygiene & Tropical Medicine. DOI: https://doi.org/10.17037/PUBS.04656053

Sun, Li; Brentnall, Adam; Patel, Shreeya; Buist, Diana SM; Bowles, Erin JA; Evans, D Gareth R; Eccles, Diana; Hopper, John; Li, Shuai; Southey, Melissa; +8 more... Duffy, Stephen; Cuzick, Jack; Dos Santos Silva, Isabel; Miners, Alec; Sadique, Zia; Yang, Li; Legood, Rosa; Manchanda, Ranjit; (2019) A Cost-effectiveness Analysis of Multigene Testing for All Patients With Breast Cancer. JAMA oncology, 5 (12). pp. 1718-1730. ISSN 2374-2437 DOI: https://doi.org/10.1001/jamaoncol.2019.3323

Bonell, Chris; Allen, Elizabeth; Warren, Emily; McGowan, Jennifer; Bevilacqua, Leonardo; Jamal, Farah; Legood, Rosa; Wiggins, Meg; Opondo, Charles; Mathiot, Anne; +8 more... Sturgess, Jo; Fletcher, Adam; Sadique, Zia; Elbourne, Diana; Christie, Deborah; Bond, Lyndal; Scott, Stephen; Viner, Russell M; (2018) Effects of the Learning Together intervention on bullying and aggression in English secondary schools (INCLUSIVE): a cluster randomised controlled trial. The Lancet, 392 (10163). pp. 2452-2464. ISSN 0140-6736 DOI: https://doi.org/10.1016/S0140-6736(18)31782-3

Maitland, Kathryn; Kiguli, Sarah; Opoka, Robert O; Olupot-Olupot, Peter; Engoru, Charles; Njuguna, Patricia; Bandika, Victor; Mpoya, Ayub; Bush, Andrew; Williams, Thomas N; +5 more... Grieve, Richard; Sadique, Zia; Fraser, John; Harrison, David; Rowan, Kathy; (2018) Children’s Oxygen Administration Strategies Trial (COAST):  A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia. Wellcome Open Research, 2. p. 100. DOI: https://doi.org/10.12688/wellcomeopenres.12747.2

Richards-Belle, Alvin; Mouncey, Paul R; Wade, Dorothy; Brewin, Chris R; Emerson, Lydia M; Grieve, Richard; Harrison, David A; Harvey, Sheila; Howell, David; Mythen, Monty; +6 more... Sadique, Zia; Smyth, Deborah; Weinman, John; Welch, John; Rowan, Kathryn M; POPPI Trial Investigators; (2018) Psychological Outcomes following a nurse-led Preventative Psychological Intervention for critically ill patients (POPPI): protocol for a cluster-randomised clinical trial of a complex intervention. BMJ open, 8 (2). e020908-. ISSN 2044-6055 DOI: https://doi.org/10.1136/bmjopen-2017-020908

Sadique, Z; Harrison, DA; Bear, DE; Rowan, KM; Grieve, R; CALORIES trial investigators; (2018) Effectiveness and cost-effectiveness of early nutritional support via the parenteral versus the enteral route for critically ill adult patients. Journal of critical care, 52. pp. 237-241. ISSN 0883-9441 DOI: https://doi.org/10.1016/j.jcrc.2018.08.025 Full text not available from this repository.

Sun, Li; Legood, Rosa; Dos-Santos-Silva, Isabel; Gaiha, Shivani Mathur; Sadique, Zia; (2018) Global treatment costs of breast cancer by stage: A systematic review. PLOS ONE, 13 (11). e0207993-. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0207993

Sun, Li; Legood, Rosa; Sadique, Zia; Dos-Santos-Silva, Isabel; Yang, Li; (2018) Cost-effectiveness of risk-based breast cancer screening programme, China. Bulletin of the World Health Organization, 96 (8). pp. 568-577. ISSN 0042-9686 DOI: https://doi.org/10.2471/BLT.18.207944

Sun, Li; Legood, Rosa; Sadique, Zia; dos-Santos-Silva, Isabel; Yang, Li; (2018) Cost-effectiveness of risk-based breast cancer screening programme, China. BULLETIN OF THE WORLD HEALTH ORGANIZATION, 96 (8). pp. 568-577. ISSN 0042-9686 DOI: https://doi.org/10.2471/BLT.18.207944

Sun, Li; Sadique, Zia; Dos-Santos-Silva, Isabel; Yang, Li; Legood, Rosa; (2018) Cost-effectiveness of breast cancer screening programme for women in rural China. International journal of cancer Journal international du cancer, 144 (10). pp. 2596-2604. ISSN 0020-7136 DOI: https://doi.org/10.1002/ijc.31956

Fantaguzzi, C; Allen, E; Miners, A; Christie, D; Opondo, C; Sadique, Z; Fletcher, A; Grieve, R; Bonell, C; Viner, RM; +1 more... Legood, R; (2017) Health-related quality of life associated with bullying and aggression: a cross-sectional study in English secondary schools. The European journal of health economics. ISSN 1618-7598 DOI: https://doi.org/10.1007/s10198-017-0908-4

Hernandez Alava, Monica; Wailoo, Allan; Grimm, Sabine; Pudney, Stephen; Gomes, Manuel; Sadique, Zia; Meads, David; O'Dwyer, John; Barton, Garry; Irvine, Lisa; (2017) EQ-5D-5L versus EQ-5D-3L: The Impact on Cost Effectiveness in the United Kingdom. Value in health, 21 (1). pp. 49-56. ISSN 1098-3015 DOI: https://doi.org/10.1016/j.jval.2017.09.004

Maitland, Kathryn; Kiguli, Sarah; Opoka, Robert O; Olupot-Olupot, Peter; Engoru, Charles; Njuguna, Patricia; Bandika, Victor; Mpoya, Ayub; Bush, Andrew; Williams, Thomas N; +5 more... Grieve, Richard; Sadique, Zia; Fraser, John; Harrison, David; Rowan, Kathy; (2017) Children's Oxygen Administration Strategies Trial (COAST):  A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia. Wellcome open research, 2. 100-. ISSN 2398-502X DOI: https://doi.org/10.12688/wellcomeopenres.12747.2

Grieve, R; Sadique, Z; Gomes, M; Smith, M; Lecky, FE; Hutchinson, PJA; Menon, DK; Rowan, KM; Harrison, DA; Risk Adjustment In Neurocritical care (RAIN) Study Investigators; (2016) An evaluation of the clinical and cost-effectiveness of alternative care locations for critically ill adult patients with acute traumatic brain injury. British journal of neurosurgery, 30 (4). pp. 388-396. ISSN 0268-8697 DOI: https://doi.org/10.3109/02688697.2016.1161166

Sadique, Zia; Lopman, Ben; Cooper, Ben S; Edmunds, W John; (2016) Cost-effectiveness of Ward Closure to Control Outbreaks of Norovirus Infection in United Kingdom National Health Service Hospitals. The Journal of infectious diseases, 213 Su (suppl ). S19-S26. ISSN 0022-1899 DOI: https://doi.org/10.1093/infdis/jiv410 Full text not available from this repository.

Martineau, Adrian R; Hanifa, Yasmeen; Witt, Karolina D; Barnes, Neil C; Hooper, Richard L; Patel, Mital; Stevens, Natasha; Enayat, Zinat; Balayah, Zuhur; Syed, Asmat; +11 more... Knight, Aishah; Jolliffe, David A; Greiller, Claire L; McLaughlin, David; Venton, Timothy R; Rowe, Marion; Timms, Peter M; Clark, Duncan; Sadique, Zia; Eldridge, Sandra M; Griffiths, Christopher J; (2015) Double-blind randomised controlled trial of vitamin D3 supplementation for the prevention of acute respiratory infection in older adults and their carers (ViDiFlu). Thorax, 70 (10). pp. 953-960. ISSN 0040-6376 DOI: https://doi.org/10.1136/thoraxjnl-2015-206996 Full text not available from this repository.

Martineau, Adrian R; MacLaughlin, Beverley D; Hooper, Richard L; Barnes, Neil C; Jolliffe, David A; Greiller, Claire L; Kilpin, Kate; McLaughlin, David; Fletcher, Gareth; Mein, Charles A; +15 more... Hoti, Mimoza; Walton, Robert; Grigg, Jonathan; Timms, Peter M; Rajakulasingam, Raj K; Bhowmik, Angshu; Rowe, Marion; Venton, Timothy R; Choudhury, Aklak B; Simcock, David E; Sadique, Zia; Monteiro, William R; Corrigan, Christopher J; Hawrylowicz, Catherine M; Griffiths, Christopher J; (2015) Double-blind randomised placebo-controlled trial of bolus-dose vitamin D3 supplementation in adults with asthma (ViDiAs). Thorax, 70 (5). pp. 451-457. ISSN 0040-6376 DOI: https://doi.org/10.1136/thoraxjnl-2014-206449 Full text not available from this repository.

Sadique, Z; Grieve, R; Harrison, D; Rowan, K; (2015) Cost-Effectiveness Of Early Parenteral Versus Enteral Nutrition In Critically Ill Patients. Value in health, 18 (7). A532-. ISSN 1098-3015 DOI: https://doi.org/10.1016/j.jval.2015.09.1658 Full text not available from this repository.

Sadique, Zia; Harrison, David A; Grieve, Richard; Rowan, Kathryn M; Pearse, Rupert M; OPTIMISE study group; (2015) Cost-effectiveness of a cardiac output-guided haemodynamic therapy algorithm in high-risk patients undergoing major gastrointestinal surgery. Perioperative medicine (London, England), 4 (1). 13-. ISSN 2047-0525 DOI: https://doi.org/10.1186/s13741-015-0024-x

Macrae, Duncan; Grieve, Richard; Allen, Elizabeth; Sadique, Zia; Betts, Helen; Morris, Kevin; Pappachan, Vithayathil John; Parslow, Roger; Tasker, Robert C; Baines, Paul; +13 more... Broadhead, Michael; Duthie, Mark L; Fortune, Peter-Marc; Inwald, David; McMaster, Paddy; Peters, Mark J; Schindler, Margrid; Guerriero, Carla; Piercy, Deborah; Slavik, Zdenek; Snowdon, Claire; Van Dyck, Laura; Elbourne, Diana; (2014) A clinical and economic evaluation of Control of Hyperglycaemia in Paediatric intensive care (CHiP): a randomised controlled trial. Health technology assessment (Winchester, England), 18 (26). pp. 1-210. ISSN 1366-5278 DOI: https://doi.org/10.3310/hta18260

Macrae, Duncan; Grieve, Richard; Allen, Elizabeth; Sadique, Zia; Morris, Kevin; Pappachan, John; Parslow, Roger; Tasker, Robert C; Elbourne, Diana; CHiP Investigators; (2014) A randomized trial of hyperglycemic control in pediatric intensive care. The New England journal of medicine, 370 (2). pp. 107-118. ISSN 0028-4793 DOI: https://doi.org/10.1056/NEJMoa1302564

Martineau, Adrian R; James, Wai Yee; Hooper, Richard L; Barnes, Neil C; Jolliffe, David A; Greiller, Claire L; Islam, Kamrul; McLaughlin, David; Bhowmik, Angshu; Timms, Peter M; +12 more... Rajakulasingam, Raj K; Rowe, Marion; Venton, Timothy R; Choudhury, Aklak B; Simcock, David E; Wilks, Mark; Degun, Amarjeet; Sadique, Zia; Monteiro, William R; Corrigan, Christopher J; Hawrylowicz, Catherine M; Griffiths, Christopher J; (2014) Vitamin D3 supplementation in patients with chronic obstructive pulmonary disease (ViDiCO): a multicentre, double-blind, randomised controlled trial. The lancet Respiratory medicine, 3 (2). pp. 120-130. ISSN 2213-2600 DOI: https://doi.org/10.1016/S2213-2600(14)70255-3 Full text not available from this repository.

Harrison, D; Muskett, H; Harvey, S; Grieve, R; Shahin, J; Patel, K; Sadique, Z; Allen, E; Dybowski, R; Jit, M; +5 more... Edgeworth, J; Kibbler, C; Barnes, R; Soni, N; Rowan, K; (2013) Development and validation of a risk model for identification of non-neutropenic, critically ill adult patients at high risk of invasive Candida infection: the Fungal Infection Risk Evaluation (FIRE) Study. Health technology assessment (Winchester, England), 17 (3). pp. 1-156. ISSN 1366-5278 DOI: https://doi.org/10.3310/hta17030

Sadique, Z; Grieve, R; Harrison, DA; Jit, M; Allen, E; Rowan, KM; FIRE Study Investigators; (2013) An integrated approach to evaluating alternative risk prediction strategies: a case study comparing alternative approaches for preventing invasive fungal disease. Value in health, 16 (8). pp. 1111-1122. ISSN 1098-3015 DOI: https://doi.org/10.1016/j.jval.2013.09.006 Full text not available from this repository.

Kreif, Noemi; Grieve, Richard; Radice, Rosalba; Sadique, Zia; Ramsahai, Roland; Sekhon, Jasjeet S; (2012) Methods for estimating subgroup effects in cost-effectiveness analyses that use observational data. Medical decision making, 32 (6). pp. 750-763. ISSN 0272-989X DOI: https://doi.org/10.1177/0272989X12448929 Full text not available from this repository.

Legood, R; Sadique, Z; Patnick, J; Kitchener, H; Kelly, R; Moss, S; (2012) Cost and logistics of alternative roll-out options for implementing human papillomavirus testing as a triage in cervical screening: results of the sentinel sites study. British journal of cancer, 107 (9). pp. 1574-1579. ISSN 0007-0920 DOI: https://doi.org/10.1038/bjc.2012.435

Radice, Rosalba; Ramsahai, Roland; Grieve, Richard; Kreif, Noemi; Sadique, Zia; Sekhon, Jasjeet S; (2012) Evaluating treatment effectiveness in patient subgroups: a comparison of propensity score methods with an automated matching approach. The international journal of biostatistics, 8 (1). 25-. ISSN 2194-573X DOI: https://doi.org/10.1515/1557-4679.1382

House, Thomas; Baguelin, Marc; Van Hoek, Albert Jan; White, Peter J; Sadique, Zia; Eames, Ken; Read, Jonathan M; Hens, Niel; Melegaro, Alessia; Edmunds, W John; +1 more... Keeling, Matt J; (2011) Modelling the impact of local reactive school closures on critical care provision during an influenza pandemic. Proceedings Biological sciences / The Royal Society, 278 (1719). pp. 2753-2760. ISSN 0962-8452 DOI: https://doi.org/10.1098/rspb.2010.2688

Kitchener, HC; Blanks, R; Cubie, H; Desai, M; Dunn, G; Legood, R; Gray, A; Sadique, Z; Moss, S; MAVARIC Trial Study Group; (2011) MAVARIC - a comparison of automation-assisted and manual cervical screening: a randomised controlled trial. Health technology assessment (Winchester, England), 15 (3). iii-170. ISSN 1366-5278 DOI: https://doi.org/10.3310/hta15030

Legood, R; Sadique, Z; Gray, A; Desai, M; Moss, S; Kitchener, H; (2010) An Economic Analysis of the Manual Assessment Vs. Automated Reading in Cytology (Mavaric) Trial. [Conference or Workshop Item] https://researchonline.lshtm.ac.uk/id/eprint/3065 Full text not available from this repository.