Year Item Type Full Text

2024

An open-access dashboard to interrogate the genetic diversity of Mycobacterium tuberculosis clinical isolates. (2024) Phelan, Jody; Van den Heede, Klaas; Masyn, Serge; Verbeeck, Rudi; Clark, Taane G; Lamprecht, Dirk A; Koul, Anil; Wall, Richard J

Post-transcriptional reprogramming by thousands of mRNA untranslated regions in trypanosomes. (2024) Trenaman, Anna; Tinti, Michele; Wall, Richard J; Horn, David

2023

DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1. (2023) Braillard, Stéphanie; Keenan, Martine; Breese, Karen J; Heppell, Jacob; Abbott, Michael; Islam, Rafiqul; Shackleford, David M; Katneni, Kasiram; Crighton, Elly; Chen, Gong; Patil, Rahul; Lee, Given; White, Karen L; Carvalho, Sandra; Wall, Richard J; Chemi, Giulia; Zuccotto, Fabio; González, Silvia; Marco, Maria; Deakyne, Julianna; Standing, David; Brunori, Gino; Lyon, Jonathan J; Castañeda-Casado, Pablo; Camino, Isabel; Martinez Martinez, Maria S; Zulfiqar, Bilal; Avery, Vicky M; Feijens, Pim-Bart; Van Pelt, Natascha; Matheeussen, An; Hendrickx, Sarah; Maes, Louis; Caljon, Guy; Yardley, Vanessa; Wyllie, Susan; Charman, Susan A; Chatelain, Eric

Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues. (2023) Cleghorn, Laura AT; Wall, Richard J; Albrecht, Sébastien; MacGowan, Stuart A; Norval, Suzanne; De Rycker, Manu; Woodland, Andrew; Spinks, Daniel; Thompson, Stephen; Patterson, Stephen; Corpas Lopez, Victoriano; Dey, Gourav; Collie, Iain T; Hallyburton, Irene; Kime, Robert; Simeons, Frederick RC; Stojanovski, Laste; Frearson, Julie A; Wyatt, Paul G; Read, Kevin D; Gilbert, Ian H; Wyllie, Susan

Short-course combination treatment for experimental chronic Chagas disease. (2023) González, Silvia; Wall, Richard J; Thomas, John; Braillard, Stephanie; Brunori, Gino; Camino Díaz, Isabel; Cantizani, Juan; Carvalho, Sandra; Castañeda Casado, Pablo; Chatelain, Eric; Cotillo, Ignacio; Fiandor, Jose M; Francisco, Amanda Fortes; Grimsditch, David; Keenan, Martine; Kelly, John M; Kessler, Albane; Luise, Chiara; Lyon, Jon J; MacLean, Lorna; Marco, Maria; Martin, J Julio; Martinez Martinez, Maria S; Paterson, Christy; Read, Kevin D; Santos-Villarejo, Angel; Zuccotto, Fabio; Wyllie, Susan; Miles, Tim J; De Rycker, Manu

2022

Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas' Disease. (2022) Lima, Marta L; Tulloch, Lindsay B; Corpas-Lopez, Victoriano; Carvalho, Sandra; Wall, Richard J; Milne, Rachel; Rico, Eva; Patterson, Stephen; Gilbert, Ian H; Moniz, Sonia; MacLean, Lorna; Torrie, Leah S; Morgillo, Carmine; Horn, David; Zuccotto, Fabio; Wyllie, Susan

Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase. (2022) Milne, Rachel; Wiedemar, Natalie; Corpas-Lopez, Victoriano; Moynihan, Eoin; Wall, Richard J; Dawson, Alice; Robinson, David A; Shepherd, Sharon M; Smith, Robert J; Hallyburton, Irene; Post, John M; Dowers, Karen; Torrie, Leah S; Gilbert, Ian H; Baragaña, Beatriz; Patterson, Stephen; Wyllie, Susan

Non-canonical endogenous expression of voltage-gated sodium channel NaV 1.7 subtype by the TE671 rhabdomyosarcoma cell line. (2022) Ngum, Neville M; Aziz, Muhammad YA; Mohammed Latif, Liaque; Wall, Richard J; Duce, Ian R; Mellor, Ian R

Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis. (2022) Smith, Alasdair; Wall, Richard J; Patterson, Stephen; Rowan, Tim; Rico Vidal, Eva; Stojanovski, Laste; Huggett, Margaret; Hampton, Shahienaz E; Thomas, Michael G; Corpas Lopez, Victoriano; Gillingwater, Kirsten; Duke, Jeff; Napier, Grant; Peter, Rose; Vitouley, Hervé S; Harrison, Justin R; Milne, Rachel; Jeacock, Laura; Baker, Nicola; Davis, Susan H; Simeons, Frederick; Riley, Jennifer; Horn, David; Brun, Reto; Zuccotto, Fabio; Witty, Michael J; Wyllie, Susan; Read, Kevin D; Gilbert, Ian H

2021

DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis. (2021) Mowbray, Charles E; Braillard, Stéphanie; Glossop, Paul A; Whitlock, Gavin A; Jacobs, Robert T; Speake, Jason; Pandi, Bharathi; Nare, Bakela; Maes, Louis; Yardley, Vanessa; Freund, Yvonne; Wall, Richard J; Carvalho, Sandra; Bello, Davide; Van den Kerkhof, Magali; Caljon, Guy; Gilbert, Ian H; Corpas-Lopez, Victoriano; Lukac, Iva; Patterson, Stephen; Zuccotto, Fabio; Wyllie, Susan

Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial. (2021) Paradela, Luciana S; Wall, Richard J; Carvalho, Sandra; Chemi, Giulia; Corpas-Lopez, Victoriano; Moynihan, Eoin; Bello, Davide; Patterson, Stephen; Güther, Maria Lucia S; Fairlamb, Alan H; Ferguson, Michael AJ; Zuccotto, Fabio; Martin, Julio; Gilbert, Ian H; Wyllie, Susan

Identification of Resistance Determinants for a Promising Antileishmanial Oxaborole Series. (2021) Van den Kerkhof, Magali; Leprohon, Philippe; Mabille, Dorien; Hendrickx, Sarah; Tulloch, Lindsay B; Wall, Richard J; Wyllie, Susan; Chatelain, Eric; Mowbray, Charles E; Braillard, Stéphanie; Ouellette, Marc; Maes, Louis; Caljon, Guy

2020

Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission. (2020) Pandey, Rajan; Abel, Steven; Boucher, Matthew; Wall, Richard J; Zeeshan, Mohammad; Rea, Edward; Freville, Aline; Lu, Xueqing Maggie; Brady, Declan; Daniel, Emilie; Stanway, Rebecca R; Wheatley, Sally; Batugedara, Gayani; Hollin, Thomas; Bottrill, Andrew R; Gupta, Dinesh; Holder, Anthony A; Le Roch, Karine G; Tewari, Rita

2018

Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis. (2018) Wall, Richard J; Ferguson, David JP; Freville, Aline; Franke-Fayard, Blandine; Brady, Declan; Zeeshan, Mohammad; Bottrill, Andrew R; Wheatley, Sally; Fry, Andrew M; Janse, Chris J; Yamano, Hiroyuki; Holder, Anthony A; Guttery, David S; Tewari, Rita

2017

Compositional and expression analyses of the glideosome during the Plasmodium life cycle reveal an additional myosin light chain required for maximum motility. (2017) Green, Judith L; Wall, Richard J; Vahokoski, Juha; Yusuf, Noor A; Ridzuan, Mohd A Mohd; Stanway, Rebecca R; Stock, Jessica; Knuepfer, Ellen; Brady, Declan; Martin, Stephen R; Howell, Steven A; Pires, Isa P; Moon, Robert W; Molloy, Justin E; Kursula, Inari; Tewari, Rita; Holder, Anthony A

2015

The Plasmodium Class XIV Myosin, MyoB, Has a Distinct Subcellular Location in Invasive and Motile Stages of the Malaria Parasite and an Unusual Light Chain. (2015) Yusuf, Noor A; Green, Judith L; Wall, Richard J; Knuepfer, Ellen; Moon, Robert W; Schulte-Huxel, Christina; Stanway, Rebecca R; Martin, Stephen R; Howell, Steven A; Douse, Christopher H; Cota, Ernesto; Tate, Edward W; Tewari, Rita; Holder, Anthony A