Items where Author or Contributor is "Fletcher, Helen"

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Number of items: 111.

2020

Hayward, Sally E; Dowd, Jennifer B; Fletcher, Helen; Nellums, Laura B; Wurie, Fatima; Boccia, Delia; (2020) A systematic review of the impact of psychosocial factors on immunity: Implications for enhancing BCG response against tuberculosis. SSM - Population Health, 10. 100522-. ISSN 2352-8273 DOI: https://doi.org/10.1016/j.ssmph.2019.100522
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Painter, Hannah; Prabowo, Satria A; Cia, Felipe; Stockdale, Lisa; Tanner, Rachel; Willcocks, Samuel; Reljic, Rajko; Fletcher, Helen A; Zelmer, Andrea; (2020) Adaption of the ex vivo mycobacterial growth inhibition assay for use with murine lung cells. Scientific Reports, 10 (1). 3311-. DOI: https://doi.org/10.1038/s41598-020-60223-y
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2019

Lee, Hyejon; Kim, Jungho; Kang, Young Ae; Kim, Deok Ryun; Sim, Bora; Zelmer, Andrea; Fletcher, Helen A; Dockrell, Hazel M; Smith, Steven G; Cho, Sang-Nae; (2019) In vitro Mycobacterial Growth Inhibition in South Korean Adults With Latent TB Infection. Frontiers in Immunology, 10 (APR). 896-. DOI: https://doi.org/10.3389/fimmu.2019.00896
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Müller, Julius; Tanner, Rachel; Matsumiya, Magali; Snowden, Margaret A; Landry, Bernard; Satti, Iman; Harris, Stephanie A; O'Shea, Matthew K; Stockdale, Lisa; Marsay, Leanne; +16 more... Chomka, Agnieszka; Harrington-Kandt, Rachel; Thomas, Zita-Rose Manjaly; Naranbhai, Vivek; Stylianou, Elena; Mbandi, Stanley Kimbung; Hatherill, Mark; Hussey, Gregory; Mahomed, Hassan; Tameris, Michele; McClain, J Bruce; Evans, Thomas G; Hanekom, Willem A; Scriba, Thomas J; McShane, Helen; Fletcher, Helen A; (2019) Cytomegalovirus infection is a risk factor for tuberculosis disease in infants. JCI insight, 4 (23). ISSN 2379-3708 DOI: https://doi.org/10.1172/jci.insight.130090
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Sibley, Laura; Gooch, Karen; Wareham, Alice; Gray, Susan; Chancellor, Andrew; Dowall, Stuart; Bate, Simon; Marriott, Anthony; Dennis, Mike; White, Andrew D; +3 more... Marsh, Philip D; Fletcher, Helen; Sharpe, Sally; (2019) Differences in monocyte: lymphocyte ratio and Tuberculosis disease progression in genetically distinct populations of macaques. Scientific reports, 9 (1). 3340-. ISSN 2045-2322 DOI: https://doi.org/10.1038/s41598-019-39819-6
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2018

Fletcher, Helen A; (2018) Systems approaches to correlates of protection and progression to TB disease. Seminars in immunology, 39 (C). pp. 81-87. ISSN 1044-5323 DOI: https://doi.org/10.1016/j.smim.2018.10.001 Full text not available from this repository.

Fletcher, Helen A; Chatterjee, Mitali; Cooper, Andrea; Hussell, Tracy; Kaye, Paul M; Prior, Joann; Reljic, Rajko; Vermaak, Samantha; Vordermeier, Martin; Williams, Ann; +1 more... McShane, Helen; (2018) VALIDATE: Exploiting the synergy between complex intracellular pathogens to expedite vaccine research and development for tuberculosis, leishmaniasis, melioidosis and leprosy. F1000Research, 7. 485-. ISSN 2046-1402 DOI: https://doi.org/10.12688/f1000research.14386.1
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Gupta-Wright, Ankur; Tomlinson, Gillian S; Rangaka, Molebogeng X; Fletcher, Helen A; (2018) World TB Day 2018: The Challenge of Drug Resistant Tuberculosis. F1000Research, 7. 217-. ISSN 2046-1402 DOI: https://doi.org/10.12688/f1000research.14088.1
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McNeill, Eileen; Stylianou, Elena; Crabtree, Mark J; Harrington-Kandt, Rachel; Kolb, Anna-Lena; Diotallevi, Marina; Hale, Ashley B; Bettencourt, Paulo; Tanner, Rachel; O'Shea, Matthew K; +7 more... Matsumiya, Magali; Lockstone, Helen; Müller, Julius; Fletcher, Helen A; Greaves, David R; McShane, Helen; Channon, Keith M; (2018) Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin. NATURE COMMUNICATIONS, 9 (1). 5409-. ISSN 2041-1723 DOI: https://doi.org/10.1038/s41467-018-07714-9
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Stockdale, Lisa; Nash, Stephen; Nalwoga, Angela; Gibson, Lorna; Painter, Hannah; Raynes, John; Asiki, Gershim; Newton, Robert; Fletcher, Helen; (2018) HIV, HCMV and mycobacterial antibody levels: a cross-sectional study in a rural Ugandan cohort. Tropical Medicine & International Health, 24 (2). pp. 247-257. ISSN 1360-2276 DOI: https://doi.org/10.1111/tmi.13188
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Voss, Gerald; Casimiro, Danilo; Neyrolles, Olivier; Williams, Ann; Kaufmann, Stefan HE; McShane, Helen; Hatherill, Mark; Fletcher, Helen A; (2018) Progress and challenges in TB vaccine development. F1000Research, 7. 199-. ISSN 2046-1402 DOI: https://doi.org/10.12688/f1000research.13588.1
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2017

Andrews, Jason R; Nemes, Elisa; Tameris, Michele; Landry, Bernard S; Mahomed, Hassan; McClain, J Bruce; Fletcher, Helen A; Hanekom, Willem A; Wood, Robin; McShane, Helen; +2 more... Scriba, Thomas J; Hatherill, Mark; (2017) Serial QuantiFERON testing and tuberculosis disease risk among young children: an observational cohort study. The lancet Respiratory medicine, 5 (4). pp. 282-290. ISSN 2213-2600 DOI: https://doi.org/10.1016/S2213-2600(17)30060-7
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Brennan, Michael J; Tanner, Rachel; Morris, Sheldon; Scriba, Thomas J; Achkar, Jacqueline M; Zelmer, Andrea; Hokey, David A; Izzo, Angelo; Sharpe, Sally; Williams, Ann; +6 more... Penn-Nicholson, Adam; Erasmus, Mzwandile; Stylianou, Elena; Hoft, Daniel F; McShane, Helen; Fletcher, Helen A; (2017) The Cross-Species Mycobacterial Growth Inhibition Assay (MGIA) Project, 2010-2014. Clinical and vaccine immunology, 24 (9). ISSN 1556-6811 DOI: https://doi.org/10.1128/CVI.00142-17
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Scriba, Thomas J; Coussens, Anna K; Fletcher, Helen A; (2017) Human Immunology of Tuberculosis. Microbiology Spectrum, 4 (5). 24-. DOI: https://doi.org/10.1128/microbiolspec.TBTB2-0016-2016 Full text not available from this repository.

Scriba, Thomas J; Coussens, Anna K; Fletcher, Helen A; (2017) Human Immunology of Tuberculosis. Microbiology Spectrum, 5 (1). ISSN 2165-0497 DOI: https://doi.org/10.1128/microbiolspec.tbtb2-0016-2016
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Tanner, Rachel; O'Shea, Matthew K; White, Andrew D; Müller, Julius; Harrington-Kandt, Rachel; Matsumiya, Magali; Dennis, Mike J; Parizotto, Eneida A; Harris, Stephanie; Stylianou, Elena; +6 more... Naranbhai, Vivek; Bettencourt, Paulo; Drakesmith, Hal; Sharpe, Sally; Fletcher, Helen A; McShane, Helen; (2017) The influence of haemoglobin and iron on in vitro mycobacterial growth inhibition assays. Scientific reports, 7 (1). 43478-. ISSN 2045-2322 DOI: https://doi.org/10.1038/srep43478
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2016

Abubakar, Ibrahim; Lipman, Marc; McHugh, Timothy D; Fletcher, Helen; (2016) Uniting to end the TB epidemic: advances in disease control from prevention to better diagnosis and treatment. BMC medicine, 14 (1). 47-. ISSN 1741-7015 DOI: https://doi.org/10.1186/s12916-016-0599-1
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Chen, Tingting; Blanc, Caroline; Eder, Anke Z; Prados-Rosales, Rafael; Souza, Ana Camila Oliveira; Kim, Ryung S; Glatman-Freedman, Aharona; Joe, Maju; Bai, Yu; Lowary, Todd L; +6 more... Tanner, Rachel; Brennan, Michael J; Fletcher, Helen A; McShane, Helen; Casadevall, Arturo; Achkar, Jacqueline M; (2016) Association of Human Antibodies to Arabinomannan With Enhanced Mycobacterial Opsonophagocytosis and Intracellular Growth Reduction. The Journal of infectious diseases, 214 (2). pp. 300-310. ISSN 0022-1899 DOI: https://doi.org/10.1093/infdis/jiw141
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Fletcher, Helen A; Filali-Mouhim, Ali; Nemes, Elisa; Hawkridge, Anthony; Keyser, Alana; Njikan, Samuel; Hatherill, Mark; Scriba, Thomas J; Abel, Brian; Kagina, Benjamin M; +7 more... Veldsman, Ashley; Agudelo, Nancy Marín; Kaplan, Gilla; Hussey, Gregory D; Sekaly, Rafick-Pierre; Hanekom, Willem A; BCG study team; (2016) Human newborn bacille Calmette-Guérin vaccination and risk of tuberculosis disease: a case-control study. BMC medicine, 14 (1). 76-. ISSN 1741-7015 DOI: https://doi.org/10.1186/s12916-016-0617-3
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Fletcher, Helen A; Schrager, Lewis; (2016) TB vaccine development and the End TB Strategy: importance and current status. Transactions of the Royal Society of Tropical Medicine and Hygiene, 110 (4). pp. 212-218. ISSN 0035-9203 DOI: https://doi.org/10.1093/trstmh/trw016
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Fletcher, Helen A; Snowden, Margaret A; Landry, Bernard; Rida, Wasima; Satti, Iman; Harris, Stephanie A; Matsumiya, Magali; Tanner, Rachel; O'Shea, Matthew K; Dheenadhayalan, Veerabadran; +20 more... Bogardus, Leah; Stockdale, Lisa; Marsay, Leanne; Chomka, Agnieszka; Harrington-Kandt, Rachel; Manjaly-Thomas, Zita-Rose; Naranbhai, Vivek; Stylianou, Elena; Darboe, Fatoumatta; Penn-Nicholson, Adam; Nemes, Elisa; Hatherill, Mark; Hussey, Gregory; Mahomed, Hassan; Tameris, Michele; McClain, J Bruce; Evans, Thomas G; Hanekom, Willem A; Scriba, Thomas J; McShane, Helen; (2016) T-cell activation is an immune correlate of risk in BCG vaccinated infants. Nature communications, 7 (1). 11290-. ISSN 2041-1723 DOI: https://doi.org/10.1038/ncomms11290
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Khan, Mishal S; Fletcher, Helen; London School of Hygiene and Tropical Medicine TB Centre Steerin; Coker, Richard; (2016) Investments in tuberculosis research - what are the gaps? BMC medicine, 14 (1). 123-. ISSN 1741-7015 DOI: https://doi.org/10.1186/s12916-016-0644-0
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Phillips, Patrick PJ; Fletcher, Helen A; Abubakar, Ibrahim; Lipman, Marc CI; McHugh, Timothy D; (2016) World TB Day 2016: an interview with leading experts in tuberculosis research. BMC medicine, 14 (1). 55-. ISSN 1741-7015 DOI: https://doi.org/10.1186/s12916-016-0591-9
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Scriba, TJ; Coussens, AK; Fletcher, HA; (2016) Human Immunology of Tuberculosis. Microbiology spectrum, 4 (5). ISSN 2165-0497 DOI: https://doi.org/10.1128/microbiolspec.TBTB2-0016-2016 Full text not available from this repository.

Vainieri, Maria L; Blagborough, Andrew M; MacLean, Adam L; Haltalli, Myriam LR; Ruivo, Nicola; Fletcher, Helen A; Stumpf, Michael PH; Sinden, Robert E; Celso, Cristina Lo; (2016) Systematic tracking of altered haematopoiesis during sporozoite-mediated malaria development reveals multiple response points. Open biology, 6 (6). p. 160038. ISSN 2046-2441 DOI: https://doi.org/10.1098/rsob.160038
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Zelmer, Andrea; Tanner, Rachel; Stylianou, Elena; Damelang, Timon; Morris, Sheldon; Izzo, Angelo; Williams, Ann; Sharpe, Sally; Pepponi, Ilaria; Walker, Barry; +4 more... Hokey, David A; McShane, Helen; Brennan, Michael; Fletcher, Helen; (2016) A new tool for tuberculosis vaccine screening: Ex vivo Mycobacterial Growth Inhibition Assay indicates BCG-mediated protection in a murine model of tuberculosis. BMC infectious diseases, 16 (1). 412-. ISSN 1471-2334 DOI: https://doi.org/10.1186/s12879-016-1751-4
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2015

Dunachie, Susanna; Hill, Adrian VS; Fletcher, Helen A; (2015) Profiling the host response to malaria vaccination and malaria challenge. Vaccine, 33 (40). pp. 5316-5320. ISSN 0264-410X DOI: https://doi.org/10.1016/j.vaccine.2015.07.107
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Fletcher, Helen A; (2015) Profiling the host immune response to tuberculosis vaccines. Vaccine, 33 (40). pp. 5313-5315. ISSN 0264-410X DOI: https://doi.org/10.1016/j.vaccine.2015.07.090 Full text not available from this repository.

Jenjaroen, Kemajittra; Chumseng, Suchintana; Sumonwiriya, Manutsanun; Ariyaprasert, Pitchayanant; Chantratita, Narisara; Sunyakumthorn, Piyanate; Hongsuwan, Maliwan; Wuthiekanun, Vanaporn; Fletcher, Helen A; Teparrukkul, Prapit; +3 more... Limmathurotsakul, Direk; Day, Nicholas PJ; Dunachie, Susanna J; (2015) T-Cell Responses Are Associated with Survival in Acute Melioidosis Patients. PLoS neglected tropical diseases, 9 (10). e0004152-. ISSN 1935-2727 DOI: https://doi.org/10.1371/journal.pntd.0004152
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Kaufmann, Stefan HE; Fletcher, Helen A; Guzmán, Carlos A; Ottenhoff, Tom HM; (2015) Big Data in Vaccinology: Introduction and section summaries. Vaccine, 33 (40). pp. 5237-5240. ISSN 0264-410X DOI: https://doi.org/10.1016/j.vaccine.2015.04.078 Full text not available from this repository.

Naranbhai, Vivek; Fletcher, Helen A; Tanner, Rachel; O'Shea, Matthew K; McShane, Helen; Fairfax, Benjamin P; Knight, Julian C; Hill, Adrian VS; (2015) Distinct Transcriptional and Anti-Mycobacterial Profiles of Peripheral Blood Monocytes Dependent on the Ratio of Monocytes: Lymphocytes. EBioMedicine, 2 (11). pp. 1619-1626. ISSN 2352-3964 DOI: https://doi.org/10.1016/j.ebiom.2015.09.027
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Schito, Marco; Migliori, Giovanni Battista; Fletcher, Helen A; McNerney, Ruth; Centis, Rosella; D'Ambrosio, Lia; Bates, Matthew; Kibiki, Gibson; Kapata, Nathan; Corrah, Tumena; +6 more... Bomanji, Jamshed; Vilaplana, Cris; Johnson, Daniel; Mwaba, Peter; Maeurer, Markus; Zumla, Alimuddin; (2015) Perspectives on Advances in Tuberculosis Diagnostics, Drugs, and Vaccines. Clinical infectious diseases, 61Supp (suppl ). S102-S118. ISSN 1058-4838 DOI: https://doi.org/10.1093/cid/civ609 Full text not available from this repository.

Smith, Steven G; Smits, Kaatje; Joosten, Simone A; van Meijgaarden, Krista E; Satti, Iman; Fletcher, Helen A; Caccamo, Nadia; Dieli, Francesco; Mascart, Francoise; McShane, Helen; +3 more... Dockrell, Hazel M; Ottenhoff, Tom HM; TBVI TB Biomarker Working Group; (2015) Intracellular Cytokine Staining and Flow Cytometry: Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines. PloS one, 10 (9). e0138042-. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0138042
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2014

Dutruel, Céline; Thole, Jelle; Geels, Mark; Mollenkopf, Hans-Joachim; Ottenhoff, Tom; Guzman, Carlos A; Fletcher, Helen A; Leroy, Odile; Kaufmann, Stefan HE; (2014) TRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: 'how can big data help?'. Vaccine, 32 (35). pp. 4365-4368. ISSN 0264-410X DOI: https://doi.org/10.1016/j.vaccine.2014.06.014
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Harris, Stephanie A; Satti, Iman; Matsumiya, Magali; Stockdale, Lisa; Chomka, Agnieszka; Tanner, Rachel; O'Shea, Matthew K; Manjaly Thomas, Zita-Rose; Tameris, Michele; Mahomed, Hassan; +4 more... Scriba, Thomas J; Hanekom, Willem A; Fletcher, Helen A; McShane, Helen; (2014) Process of assay selection and optimization for the study of case and control samples from a phase IIb efficacy trial of a candidate tuberculosis vaccine, MVA85A. Clinical and vaccine immunology, 21 (7). pp. 1005-1011. ISSN 1556-6811 DOI: https://doi.org/10.1128/CVI.00128-14
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Matsumiya, Magali; Harris, Stephanie A; Satti, Iman; Stockdale, Lisa; Tanner, Rachel; O'Shea, Matthew K; Tameris, Michelle; Mahomed, Hassan; Hatherill, Mark; Scriba, Thomas J; +3 more... Hanekom, Willem A; McShane, Helen; Fletcher, Helen A; (2014) Inflammatory and myeloid-associated gene expression before and one day after infant vaccination with MVA85A correlates with induction of a T cell response. BMC infectious diseases, 14 (1). 314-. ISSN 1471-2334 DOI: https://doi.org/10.1186/1471-2334-14-314
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Matsumiya, Magali; Satti, Iman; Chomka, Agnieszka; Harris, Stephanie A; Stockdale, Lisa; Meyer, Joel; Fletcher, Helen A; McShane, Helen; (2014) Gene expression and cytokine profile correlate with mycobacterial growth in a human BCG challenge model. The Journal of infectious diseases, 211 (9). pp. 1499-1509. ISSN 0022-1899 DOI: https://doi.org/10.1093/infdis/jiu615
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Naranbhai, Vivek; Kim, Soyeon; Fletcher, Helen; Cotton, Mark F; Violari, Avy; Mitchell, Charles; Nachman, Sharon; McSherry, George; McShane, Helen; Hill, Adrian VS; +1 more... Madhi, Shabir A; (2014) The association between the ratio of monocytes:lymphocytes at age 3 months and risk of tuberculosis (TB) in the first two years of life. BMC medicine, 12 (1). 120-. ISSN 1741-7015 DOI: https://doi.org/10.1186/s12916-014-0120-7
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Naranbhai, Vivek; Moodley, Dhayendre; Chipato, Tsungai; Stranix-Chibanda, Lynda; Nakabaiito, Clemensia; Kamateeka, Moreen; Musoke, Philippa; Manji, Karim; George, Kathleen; Emel, Lynda M; +8 more... Richardson, Paul; Andrew, Philip; Fowler, MaryGlenn; Fletcher, Helen; McShane, Helen; Coovadia, Hoosen M; Hill, Adrian VS; HPTN 046 Protocol Team; (2014) The association between the ratio of monocytes: lymphocytes and risk of tuberculosis among HIV-infected postpartum women. Journal of acquired immune deficiency syndromes (1999), 67 (5). pp. 573-575. ISSN 1525-4135 DOI: https://doi.org/10.1097/QAI.0000000000000353 Full text not available from this repository.

Tanner, Rachel; Kakalacheva, Kristina; Miller, Ellen; Pathan, Ansar A; Chalk, Rod; Sander, Clare R; Scriba, Tom; Tameris, Michelle; Hawkridge, Tony; Mahomed, Hassan; +5 more... Hussey, Greg; Hanekom, Willem; Checkley, Anna; McShane, Helen; Fletcher, Helen A; (2014) Serum indoleamine 2,3-dioxygenase activity is associated with reduced immunogenicity following vaccination with MVA85A. BMC infectious diseases, 14 (1). 660-. ISSN 1471-2334 DOI: https://doi.org/10.1186/s12879-014-0660-7
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2013

Fletcher, Helen A; Tanner, Rachel; Wallis, Robert S; Meyer, Joel; Manjaly, Zita-Rose; Harris, Stephanie; Satti, Iman; Silver, Richard F; Hoft, Dan; Kampmann, Beate; +6 more... Walker, K Barry; Dockrell, Hazel M; Fruth, Uli; Barker, Lew; Brennan, Michael J; McShane, Helen; (2013) Inhibition of mycobacterial growth in vitro following primary but not secondary vaccination with Mycobacterium bovis BCG. Clinical and vaccine immunology, 20 (11). pp. 1683-1689. ISSN 1556-6811 DOI: https://doi.org/10.1128/CVI.00427-13 Full text not available from this repository.

Griffiths, Kristin L; Stylianou, Elena; Poyntz, Hazel C; Betts, Gareth J; Fletcher, Helen A; McShane, Helen; (2013) Cholera toxin enhances vaccine-induced protection against Mycobacterium tuberculosis challenge in mice. PloS one, 8 (10). e78312-. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0078312
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Harris, Stephanie A; Meyer, Joel; Satti, Iman; Marsay, Leanne; Poulton, Ian D; Tanner, Rachel; Minassian, Angela M; Fletcher, Helen A; McShane, Helen; (2013) Evaluation of a human BCG challenge model to assess antimycobacterial immunity induced by BCG and a candidate tuberculosis vaccine, MVA85A, alone and in combination. The Journal of infectious diseases, 209 (8). pp. 1259-1268. ISSN 0022-1899 DOI: https://doi.org/10.1093/infdis/jit647
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Marsay, Leanne; Matsumiya, Magali; Tanner, Rachel; Poyntz, Hazel; Griffiths, Kristin L; Stylianou, Elena; Marsh, Philip D; Williams, Ann; Sharpe, Sally; Fletcher, Helen; +1 more... McShane, Helen; (2013) Mycobacterial growth inhibition in murine splenocytes as a surrogate for protection against Mycobacterium tuberculosis (M. tb). Tuberculosis (Edinburgh, Scotland), 93 (5). pp. 551-557. ISSN 1472-9792 DOI: https://doi.org/10.1016/j.tube.2013.04.007
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Matsumiya, Magali; Stylianou, Elena; Griffiths, Kristin; Lang, Zoe; Meyer, Joel; Harris, Stephanie A; Rowland, Rosalind; Minassian, Angela M; Pathan, Ansar A; Fletcher, Helen; +1 more... McShane, Helen; (2013) Roles for Treg expansion and HMGB1 signaling through the TLR1-2-6 axis in determining the magnitude of the antigen-specific immune response to MVA85A. PloS one, 8 (7). e67922-. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0067922
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Meyer, Joel; Harris, Stephanie A; Satti, Iman; Poulton, Ian D; Poyntz, Hazel C; Tanner, Rachel; Rowland, Rosalind; Griffiths, Kristin L; Fletcher, Helen A; McShane, Helen; (2013) Comparing the safety and immunogenicity of a candidate TB vaccine MVA85A administered by intramuscular and intradermal delivery. Vaccine, 31 (7). pp. 1026-1033. ISSN 0264-410X DOI: https://doi.org/10.1016/j.vaccine.2012.12.042 Full text not available from this repository.

Naranbhai, Vivek; Hill, Adrian VS; Abdool Karim, Salim S; Naidoo, Kogieleum; Abdool Karim, Quarraisha; Warimwe, George M; McShane, Helen; Fletcher, Helen; (2013) Ratio of monocytes to lymphocytes in peripheral blood identifies adults at risk of incident tuberculosis among HIV-infected adults initiating antiretroviral therapy. The Journal of infectious diseases, 209 (4). pp. 500-509. ISSN 0022-1899 DOI: https://doi.org/10.1093/infdis/jit494
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Warimwe, George M; Fletcher, Helen A; Olotu, Ally; Agnandji, Selidji T; Hill, Adrian VS; Marsh, Kevin; Bejon, Philip; (2013) Peripheral blood monocyte-to-lymphocyte ratio at study enrollment predicts efficacy of the RTS,S malaria vaccine: analysis of pooled phase II clinical trial data. BMC medicine, 11 (1). 184-. ISSN 1741-7015 DOI: https://doi.org/10.1186/1741-7015-11-184
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Warimwe, George M; Murungi, Linda M; Kamuyu, Gathoni; Nyangweso, George M; Wambua, Juliana; Naranbhai, Vivek; Fletcher, Helen A; Hill, Adrian VS; Bejon, Philip; Osier, Faith HA; +1 more... Marsh, Kevin; (2013) The ratio of monocytes to lymphocytes in peripheral blood correlates with increased susceptibility to clinical malaria in Kenyan children. PloS one, 8 (2). e57320-. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0057320
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2012

Pathan, Ansar A; Minassian, Angela M; Sander, Clare R; Rowland, Rosalind; Porter, David W; Poulton, Ian D; Hill, Adrian VS; Fletcher, Helen A; McShane, Helen; (2012) Effect of vaccine dose on the safety and immunogenicity of a candidate TB vaccine, MVA85A, in BCG vaccinated UK adults. Vaccine, 30 (38). pp. 5616-5624. ISSN 0264-410X DOI: https://doi.org/10.1016/j.vaccine.2012.06.084
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2011

Berthoud, Tamara K; Hamill, Matthew; Lillie, Patrick J; Hwenda, Lenias; Collins, Katharine A; Ewer, Katie J; Milicic, Anita; Poyntz, Hazel C; Lambe, Teresa; Fletcher, Helen A; +2 more... Hill, Adrian VS; Gilbert, Sarah C; (2011) Potent CD8+ T-cell immunogenicity in humans of a novel heterosubtypic influenza A vaccine, MVA-NP+M1. Clinical infectious diseases, 52 (1). pp. 1-7. ISSN 1058-4838 DOI: https://doi.org/10.1093/cid/ciq015
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Griffiths, K; Stylianou, E; Poyntz, H; Betts, G; Fletcher, H; McShane, H; Beveridge, N; Minassian, A; Rowland, R; Poulton, I; +22 more... Satti, I; Harris, S; Poyntz, H; Hamill, M; Griffiths, K; Sander, C; Ambrozak, D; Price, D; Hill, B; Casazza, J; Douek, D; Koup, R; Roederer, M; Winston, A; Ross, J; Sherrad, J; Rooney, G; Williams, N; Lawrie, A; Fletcher, H; Pathan, A; McShane, H; (2011) Th1/Th17 cell induction following vaccination with the novel tuberculosis vaccine MVA85A and their role in Mycobacterium tuberculosis challenge CD4 T cell response to MVA85A vaccination against Mycobacterium tuberculosis in healthy HIV-infected adults SO IMMUNOLOGY CT Annual Congress of the British-Society-for-Immunology CY DEC 05-08, 2011 CL Liverpool, ENGLAND SP British Soc Immunol. [Conference or Workshop Item] https://researchonline.lshtm.ac.uk/id/eprint/2729027 Full text not available from this repository.

Griffiths, Kristin L; Pathan, Ansar A; Minassian, Angela M; Sander, Clare R; Beveridge, Natalie ER; Hill, Adrian VS; Fletcher, Helen A; McShane, Helen; (2011) Th1/Th17 cell induction and corresponding reduction in ATP consumption following vaccination with the novel Mycobacterium tuberculosis vaccine MVA85A. PloS one, 6 (8). e23463-. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0023463
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Kasprowicz, Victoria O; Mitchell, Jessica E; Chetty, Shivan; Govender, Pamla; Huang, Kuan-Hsiang Gary; Fletcher, Helen A; Webster, Daniel P; Brown, Sebastian; Kasmar, Anne; Millington, Kerry; +8 more... Day, Cheryl L; Mkhwanazi, Nompumelelo; McClurg, Cheryl; Chonco, Fundisiwe; Lalvani, Ajit; Walker, Bruce D; Ndung'u, Thumbi; Klenerman, Paul; (2011) A molecular assay for sensitive detection of pathogen-specific T-cells. PloS one, 6 (8). e20606-. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0020606
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Minassian, Angela M; Rowland, Rosalind; Beveridge, Natalie ER; Poulton, Ian D; Satti, Iman; Harris, Stephanie; Poyntz, Hazel; Hamill, Matthew; Griffiths, Kristin; Sander, Clare R; +16 more... Ambrozak, David R; Price, David A; Hill, Brenna J; Casazza, Joseph P; Douek, Daniel C; Koup, Richard A; Roederer, Mario; Winston, Alan; Ross, Jonathan; Sherrard, Jackie; Rooney, Guy; Williams, Nicola; Lawrie, Alison M; Fletcher, Helen A; Pathan, Ansar A; McShane, Helen; (2011) A Phase I study evaluating the safety and immunogenicity of MVA85A, a candidate TB vaccine, in HIV-infected adults. BMJ open, 1 (2). e000223-. ISSN 2044-6055 DOI: https://doi.org/10.1136/bmjopen-2011-000223
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Moore, CE; Hennig, BJ; Perrett, KP; Hoe, JC; Lee, SJ; Fletcher, H; Brocklebank, D; O'Connor, D; Snape, MD; Hall, AJ; +3 more... Segal, S; Hill, AVS; Pollard, AJ; (2011) Single Nucleotide Polymorphisms in the Toll-Like Receptor 3 and CD44 Genes Are Associated with Persistence of Vaccine-Induced Immunity to the Serogroup C Meningococcal Conjugate Vaccine. [Conference or Workshop Item] https://doi.org/10.1128/CVI.05379-11 Full text not available from this repository.

2010

Dunachie, Susanna J; Berthoud, Tamara; Keating, Sheila M; Hill, Adrian VS; Fletcher, Helen A; (2010) MIG and the regulatory cytokines IL-10 and TGF-β1 correlate with malaria vaccine immunogenicity and efficacy. PloS one, 5 (9). e12557-. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0012557
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Lienhardt, Christian; Fielding, Katherine; Hane, Abdoul A; Niang, Aliou; Ndao, Cheikh T; Karam, Farba; Fletcher, Helen; Mbow, Fatou; Gomis, Jules-François; Diadhiou, Raymond; +3 more... Toupane, Maxime; Dieye, Tandakha; Mboup, Souleymane; (2010) Evaluation of the prognostic value of IFN-gamma release assay and tuberculin skin test in household contacts of infectious tuberculosis cases in Senegal. PloS one, 5 (5). e10508-. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0010508
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de Cassan, Simone C; Pathan, Ansar A; Sander, Clare R; Minassian, Angela; Rowland, Rosalind; Hill, Adrian VS; McShane, Helen; Fletcher, Helen A; (2010) Investigating the induction of vaccine-induced Th17 and regulatory T cells in healthy, Mycobacterium bovis BCG-immunized adults vaccinated with a new tuberculosis vaccine, MVA85A. Clinical and vaccine immunology, 17 (7). pp. 1066-1073. ISSN 1556-6811 DOI: https://doi.org/10.1128/CVI.00047-10 Full text not available from this repository.

2009

Berthoud, Tamara K; Dunachie, Susanna J; Todryk, Stephen; Hill, Adrian VS; Fletcher, Helen A; (2009) MIG (CXCL9) is a more sensitive measure than IFN-gamma of vaccine induced T-cell responses in volunteers receiving investigated malaria vaccines. Journal of immunological methods, 340 (1). pp. 33-41. ISSN 0022-1759 DOI: https://doi.org/10.1016/j.jim.2008.09.021
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Berthoud, Tamara K; Fletcher, Helen; Porter, David; Thompson, Fiona; Hill, Adrian VS; Todryk, Stephen M; (2009) Comparing human T cell and NK cell responses in viral-based malaria vaccine trials. Vaccine, 28 (1). pp. 21-27. ISSN 0264-410X DOI: https://doi.org/10.1016/j.vaccine.2009.09.132 Full text not available from this repository.

Fletcher, Helen A; Hawkridge, Tony; McShane, Helen; (2009) A New Vaccine for Tuberculosis: The Challenges of Development and Deployment. Journal of bioethical inquiry, 6 (2). pp. 219-228. ISSN 1176-7529 DOI: https://doi.org/10.1007/s11673-009-9153-6
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Fletcher, Helen A; Keyser, Alana; Bowmaker, Mark; Sayles, Peter C; Kaplan, Gilla; Hussey, Greg; Hill, Adrian VS; Hanekom, Willem A; (2009) Transcriptional profiling of mycobacterial antigen-induced responses in infants vaccinated with BCG at birth. BMC medical genomics, 2 (1). 10-. ISSN 1755-8794 DOI: https://doi.org/10.1186/1755-8794-2-10
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Mwacharo, Jedidah; Dunachie, Susanna J; Kai, Oscar; Hill, Adrian VS; Bejon, Philip; Fletcher, Helen A; (2009) Quantitative PCR evaluation of cellular immune responses in Kenyan children vaccinated with a candidate malaria vaccine. PloS one, 4 (12). e8434-. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0008434
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Whelan, Kathryn T; Pathan, Ansar A; Sander, Clare R; Fletcher, Helen A; Poulton, Ian; Alder, Nicola C; Hill, Adrian VS; McShane, Helen; (2009) Safety and immunogenicity of boosting BCG vaccinated subjects with BCG: comparison with boosting with a new TB vaccine, MVA85A. PloS one, 4 (6). e5934-. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0005934
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2008

Beveridge, Natalie ER; Fletcher, Helen A; Hughes, Jane; Pathan, Ansar A; Scriba, Thomas J; Minassian, Angela; Sander, Clare R; Whelan, Kathryn T; Dockrell, Hazel M; Hill, Adrian VS; +2 more... Hanekom, Willem A; McShane, Helen; (2008) A comparison of IFNgamma detection methods used in tuberculosis vaccine trials. Tuberculosis (Edinburgh, Scotland), 88 (6). pp. 631-640. ISSN 1472-9792 DOI: https://doi.org/10.1016/j.tube.2008.06.005 Full text not available from this repository.

Brookes, Roger H; Hill, Philip C; Owiafe, Patrick K; Ibanga, Hannah B; Jeffries, David J; Donkor, Simon A; Fletcher, Helen A; Hammond, Abdulrahman S; Lienhardt, Christian; Adegbola, Richard A; +2 more... McShane, Helen; Hill, Adrian VS; (2008) Safety and immunogenicity of the candidate tuberculosis vaccine MVA85A in West Africa. PloS one, 3 (8). e2921-. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0002921
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Fletcher, Helen A; Pathan, Ansar A; Berthoud, Tamara K; Dunachie, Susanna J; Whelan, Kathryn T; Alder, Nicola C; Sander, Clare R; Hill, Adrian VS; McShane, Helen; (2008) Boosting BCG vaccination with MVA85A down-regulates the immunoregulatory cytokine TGF-beta1. Vaccine, 26 (41). pp. 5269-5275. ISSN 0264-410X DOI: https://doi.org/10.1016/j.vaccine.2008.07.040
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Hanekom, Willem A; Dockrell, Hazel M; Ottenhoff, Tom HM; Doherty, T Mark; Fletcher, Helen; McShane, Helen; Weichold, Frank F; Hoft, Dan F; Parida, Shreemanta K; Fruth, Uli J; (2008) Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations. PLoS medicine, 5 (7). e145-. ISSN 1549-1277 DOI: https://doi.org/10.1371/journal.pmed.0050145
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Hawkridge, Tony; Scriba, Thomas J; Gelderbloem, Sebastian; Smit, Erica; Tameris, Michele; Moyo, Sizulu; Lang, Trudie; Veldsman, Ashley; Hatherill, Mark; Merwe, Linda van der; +6 more... Fletcher, Helen A; Mahomed, Hassan; Hill, Adrian VS; Hanekom, Willem A; Hussey, Gregory D; McShane, Helen; (2008) Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South Africa. The Journal of infectious diseases, 198 (4). pp. 544-552. ISSN 0022-1899 DOI: https://doi.org/10.1086/590185 Full text not available from this repository.

Karam, Farba; Mbow, Fatou; Fletcher, Helen; Senghor, Cheikh S; Coulibaly, Koura D; LeFevre, Andrea M; Ngom Gueye, Ndeye F; Dieye, Tandakha; Sow, Papa S; Mboup, Souleymane; +1 more... Lienhardt, Christian; (2008) Sensitivity of IFN-gamma release assay to detect latent tuberculosis infection is retained in HIV-infected patients but dependent on HIV/AIDS progression. PloS one, 3 (1). e1441-. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0001441
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2007

Fletcher, Helen A; (2007) Correlates of immune protection from tuberculosis. Current molecular medicine, 7 (3). pp. 319-325. ISSN 1566-5240 DOI: https://doi.org/10.2174/156652407780598520 Full text not available from this repository.

Pathan, Ansar A; Sander, Clare R; Fletcher, Helen A; Poulton, Ian; Alder, Nicola C; Beveridge, Natalie ER; Whelan, Kathryn T; Hill, Adrian VS; McShane, Helen; (2007) Boosting BCG with recombinant modified vaccinia ankara expressing antigen 85A: different boosting intervals and implications for efficacy trials. PloS one, 2 (10). e1052-. ISSN 1932-6203 DOI: https://doi.org/10.1371/journal.pone.0001052
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2006

Demissie, Abebech; Leyten, Eliane MS; Abebe, Markos; Wassie, Liya; Aseffa, Abraham; Abate, Getahun; Fletcher, Helen; Owiafe, Patrick; Hill, Philip C; Brookes, Roger; +8 more... Rook, Graham; Zumla, Alimuddin; Arend, Sandra M; Klein, Michel; Ottenhoff, Tom HM; Andersen, Peter; Doherty, T Mark; VACSEL Study Group; (2006) Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with Mycobacterium tuberculosis. Clinical and vaccine immunology, 13 (2). pp. 179-186. ISSN 1556-6811 DOI: https://doi.org/10.1128/CVI.13.2.179-186.2006 Full text not available from this repository.

Fletcher, Helen; McShane, Helen; (2006) Tuberculosis vaccines: current status and future prospects. Expert opinion on emerging drugs, 11 (2). pp. 207-215. ISSN 1472-8214 DOI: https://doi.org/10.1517/14728214.11.2.207 Full text not available from this repository.

Ibanga, Hannah B; Brookes, Roger H; Hill, Philip C; Owiafe, Patrick K; Fletcher, Helen A; Lienhardt, Christian; Hill, Adrian VS; Adegbola, Richard A; McShane, Helen; (2006) Early clinical trials with a new tuberculosis vaccine, MVA85A, in tuberculosis-endemic countries: issues in study design. The Lancet infectious diseases, 6 (8). pp. 522-528. ISSN 1473-3099 DOI: https://doi.org/10.1016/S1473-3099(06)70552-7 Full text not available from this repository.

2005

McShane, Helen; Pathan, Ansar A; Sander, Clare R; Goonetilleke, Nilu P; Fletcher, Helen A; Hill, Adrian VS; (2005) Boosting BCG with MVA85A: the first candidate subunit vaccine for tuberculosis in clinical trials. Tuberculosis (Edinburgh, Scotland), 85 (1-2). pp. 47-52. ISSN 1472-9792 DOI: https://doi.org/10.1016/j.tube.2004.09.015 Full text not available from this repository.

Walther, Michael; Tongren, Jon Eric; Andrews, Laura; Korbel, Daniel; King, Elizabeth; Fletcher, Helen; Andersen, Rikke F; Bejon, Philip; Thompson, Fiona; Dunachie, Susanna J; +6 more... Edele, Fanny; de Souza, J Brian; Sinden, Robert E; Gilbert, Sarah C; Riley, Eleanor M; Hill, Adrian VS; (2005) Upregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection. Immunity, 23 (3). pp. 287-296. ISSN 1074-7613 DOI: https://doi.org/10.1016/j.immuni.2005.08.006 Full text not available from this repository.

2004

Demissie, Abebech; Abebe, Markos; Aseffa, Abraham; Rook, Graham; Fletcher, Helen; Zumla, Alimuddin; Weldingh, Karin; Brock, Inger; Andersen, Peter; Doherty, T Mark; +1 more... VACSEL Study Group; (2004) Healthy individuals that control a latent infection with Mycobacterium tuberculosis express high levels of Th1 cytokines and the IL-4 antagonist IL-4delta2. Journal of immunology (Baltimore, Md, 172 (11). pp. 6938-6943. ISSN 0022-1767 DOI: https://doi.org/10.4049/jimmunol.172.11.6938 Full text not available from this repository.

Fletcher, Helen A; Owiafe, Patrick; Jeffries, David; Hill, Philip; Rook, Graham AW; Zumla, Alimuddin; Doherty, T Mark; Brookes, Roger H; Vacsel Study Group; (2004) Increased expression of mRNA encoding interleukin (IL)-4 and its splice variant IL-4delta2 in cells from contacts of Mycobacterium tuberculosis, in the absence of in vitro stimulation. Immunology, 112 (4). pp. 669-673. ISSN 0019-2805 DOI: https://doi.org/10.1111/j.1365-2567.2004.01922.x Full text not available from this repository.

McShane, Helen; Pathan, Ansar A; Sander, Clare R; Keating, Sheila M; Gilbert, Sarah C; Huygen, Kris; Fletcher, Helen A; Hill, Adrian VS; (2004) Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans. Nature medicine, 10 (11). pp. 1240-1244. ISSN 1078-8956 DOI: https://doi.org/10.1038/nm1128 Full text not available from this repository.

2003

Fletcher, Helen A; Donoghue, Helen D; Holton, John; Pap, Ildikó; Spigelman, Mark; (2003) Widespread occurrence of Mycobacterium tuberculosis DNA from 18th-19th century Hungarians. American journal of physical anthropology, 120 (2). pp. 144-152. ISSN 0002-9483 DOI: https://doi.org/10.1002/ajpa.10114 Full text not available from this repository.

Fletcher, Helen A; Donoghue, Helen D; Taylor, G Michael; van der Zanden, Adri GM; Spigelman, Mark; (2003) Molecular analysis of Mycobacterium tuberculosis DNA from a family of 18th century Hungarians. Microbiology (Reading, England), 149 (Pt 1). pp. 143-151. ISSN 1350-0872 DOI: https://doi.org/10.1099/mic.0.25961-0 Full text not available from this repository.

2002

Ferns, R Bridget; Fletcher, Helen; Bradley, Susan; Mackinnon, Stephen; Hunt, Chris; Tedder, Richard S; (2002) The prospective evaluation of a nested polymerase chain reaction assay for the early detection of Aspergillus infection in patients with leukaemia or undergoing allograft treatment. British journal of haematology, 119 (3). pp. 720-725. ISSN 0007-1048 DOI: https://doi.org/10.1046/j.1365-2141.2002.03862.x Full text not available from this repository.

Kasolo, Francis; Lishimpi, Kennedy; Chintu, Chifumbe; Mwaba, Peter; Mudenda, Victor; Maswahu, Daniel; Terunuma, Hiroshi; Fletcher, Helen; Nunn, Andrew; Lucas, Sebastian; +1 more... Zumla, Alimuddin; (2002) Identification of Pneumocystis carinii DNA by polymerase chain reaction in necropsy lung samples from children dying of respiratory tract illnesses. The Journal of pediatrics, 140 (3). pp. 367-369. ISSN 0022-3476 DOI: https://doi.org/10.1067/mpd.2002.122468 Full text not available from this repository.

2001

Fletcher, HA; (2001) Molecular epidemiology of tuberculosis: recent developments and applications. Current opinion in pulmonary medicine, 7 (3). pp. 154-159. ISSN 1070-5287 DOI: https://doi.org/10.1097/00063198-200105000-00007 Full text not available from this repository.

This list was generated on Wed Aug 12 06:46:08 2020 BST.