Items where Author is "Kelly, JM"
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Number of items: 31.
Article
Adjogatse, E;
Erskine, P;
Wells, SA;
Kelly, JM;
Wilden, JD;
Chan, AWE;
Selwood, D;
Coker, A;
Wood, S;
Cooper, JB;
(2018)
Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.
Acta crystallographica Section D, Structural biology, 74 (Pt 9).
pp. 861-876.
ISSN 2059-7983
DOI: https://doi.org/10.1107/S2059798318009208
Item availability may be restricted.
Bistrović, A;
Krstulović, L;
Stolić, I;
Drenjančević, D;
Talapko, J;
Taylor, MC;
Kelly, JM;
Bajić, M;
Raić-Malić, S;
(2018)
Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA.
Journal of enzyme inhibition and medicinal chemistry, 33 (1).
pp. 1323-1334.
ISSN 1475-6366
DOI: https://doi.org/10.1080/14756366.2018.1484733
Brand, S;
Ko, EJ;
Viayna, E;
Thompson, S;
Spinks, D;
Thomas, M;
Sandberg, L;
Francisco, AF;
Jayawardhana, S;
Smith, VC;
+26 more...
Jansen, C;
De Rycker, M;
Thomas, J;
MacLean, L;
Osuna-Cabello, M;
Riley, J;
Scullion, P;
Stojanovski, L;
Simeons, FRC;
Epemolu, O;
Shishikura, Y;
Crouch, SD;
Bakshi, TS;
Nixon, CJ;
Reid, IH;
Hill, AP;
Underwood, TZ;
Hindley, SJ;
Robinson, SA;
Kelly, JM;
Fiandor, JM;
Wyatt, PG;
Marco, M;
Miles, TJ;
Read, KD;
Gilbert, IH;
(2017)
Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi.
Journal of medicinal chemistry.
ISSN 0022-2623
DOI: https://doi.org/10.1021/acs.jmedchem.7b00463
Campos, MC;
Leon, LL;
Taylor, MC;
Kelly, JM;
(2014)
Benznidazole-resistance in Trypanosoma cruzi: evidence that distinct mechanisms can act in concert.
Molecular and biochemical parasitology, 193 (1).
pp. 17-9.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2014.01.002
Campos, MC;
Phelan, J;
Francisco, AF;
Taylor, MC;
Lewis, MD;
Pain, A;
Clark, TG;
Kelly, JM;
(2017)
Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole.
Scientific reports, 7 (1).
p. 14407.
ISSN 2045-2322
DOI: https://doi.org/10.1038/s41598-017-14986-6
Costa, FC;
Francisco, AF;
Jayawardhana, S;
Calderano, SG;
Lewis, MD;
Olmo, F;
Beneke, T;
Gluenz, E;
Sunter, J;
Dean, S;
+2 more...
Kelly, JM;
Taylor, MC;
(2018)
Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping.
PLoS neglected tropical diseases, 12 (4).
e0006388.
ISSN 1935-2727
DOI: https://doi.org/10.1371/journal.pntd.0006388
Di Pietro, O;
Vicente-García, E;
Taylor, MC;
Berenguer, D;
Viayna, E;
Lanzoni, A;
Sola, I;
Sayago, H;
Riera, C;
Fisa, R;
+5 more...
Clos, MV;
Pérez, B;
Kelly, JM;
Lavilla, R;
Muñoz-Torrero, D;
(2015)
Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity.
European journal of medicinal chemistry, 105.
pp. 120-137.
ISSN 0223-5234
DOI: https://doi.org/10.1016/j.ejmech.2015.10.007
Fortes Francisco, A;
Jayawardhana, S;
Taylor, MC;
Lewis, MD;
Kelly, JM;
(2018)
Assessing the effectiveness of curative benznidazole treatment in preventing chronic cardiac pathology in experimental models of Chagas disease.
Antimicrobial agents and chemotherapy.
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.00832-18
Fortes Francisco, A;
Lewis, MD;
Jayawardhana, S;
Taylor, MC;
Chatelain, E;
Kelly, JM;
(2015)
The limited ability of posaconazole to cure both acute and chronic Trypanosoma cruzi infections revealed by highly sensitive in vivo imaging.
Antimicrobial agents and chemotherapy.
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.00520-15
Francisco, AF;
Jayawardhana, S;
Lewis, MD;
Taylor, MC;
Kelly, JM;
(2017)
Biological factors that impinge on Chagas disease drug development.
Parasitology.
pp. 1-10.
ISSN 0031-1820
DOI: https://doi.org/10.1017/S0031182017001469
Francisco, AF;
Jayawardhana, S;
Lewis, MD;
White, KL;
Shackleford, DM;
Chen, G;
Saunders, J;
Osuna-Cabello, M;
Read, KD;
Charman, SA;
+2 more...
Chatelain, E;
Kelly, JM;
(2016)
Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage.
Scientific reports, 6.
p. 35351.
ISSN 2045-2322
DOI: https://doi.org/10.1038/srep35351
Francisco, AF;
Lewis, MD;
Jayawardhana, S;
Taylor, MC;
Chatelain, E;
Kelly, JM;
(2015)
Reply to "Drug Susceptibility of Genetically Engineered Trypanosoma cruzi Strains and Sterile Cure in Animal Models as a Criterion for Potential Clinical Efficacy of Anti-T. cruzi Drugs".
Antimicrobial agents and chemotherapy, 59 (12).
p. 7925.
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.02022-15
Full text not available from this repository.
Ghashghaei, O;
Kielland, N;
Revés, M;
Taylor, MC;
Kelly, JM;
Di Pietro, O;
Muñoz-Torrero, D;
Pérez, B;
Lavilla, R;
(2018)
Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases.
Molecules (Basel, Switzerland), 23 (1).
ISSN 1420-3049
DOI: https://doi.org/10.3390/molecules23010177
Kelly, JM;
Quack, G;
Miles, MM;
(2001)
In vitro and in vivo activities of aminoadamantane and aminoalkylcyclohexane derivatives against Trypanosoma brucei.
Antimicrobial agents and chemotherapy, 45 (5).
pp. 1360-6.
ISSN 0066-4804
DOI: https://doi.org/10.1128/AAC.45.5.1360-1366.2001
Full text not available from this repository.
Kishore, KG;
Ghashghaei, O;
Estarellas, C;
Mestre, MM;
Monturiol, C;
Kielland, N;
Kelly, JM;
Francisco, AF;
Jayawardhana, S;
Muñoz-Torrero, D;
+4 more...
Pérez, B;
Luque, FJ;
Gámez-Montaño, R;
Lavilla, R;
(2016)
Insertion of Isocyanides into N-Si Bonds: Multicomponent Reactions with Azines Leading to Potent Antiparasitic Compounds.
Angewandte Chemie (International ed in English), 55 (31).
pp. 8994-8.
ISSN 1433-7851
DOI: https://doi.org/10.1002/anie.201604109
Full text not available from this repository.
Lewis, MD;
Fortes Francisco, A;
Taylor, MC;
Burrell-Saward, H;
McLatchie, AP;
Miles, MA;
Kelly, JM;
(2014)
Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infection.
Cellular microbiology, 16 (9).
pp. 1285-300.
ISSN 1462-5814
DOI: https://doi.org/10.1111/cmi.12297
Lewis, MD;
Francisco, AF;
Jayawardhana, S;
Langston, H;
Taylor, MC;
Kelly, JM;
(2018)
Imaging the development of chronic Chagas disease after oral transmission.
Scientific reports, 8 (1).
p. 11292.
ISSN 2045-2322
DOI: https://doi.org/10.1038/s41598-018-29564-7
Lewis, MD;
Francisco, AF;
Taylor, MC;
Jayawardhana, S;
Kelly, JM;
(2016)
Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathy.
Cellular microbiology.
ISSN 1462-5814
DOI: https://doi.org/10.1111/cmi.12584
Lewis, MD;
Francisco, AF;
Taylor, MC;
Kelly, JM;
(2014)
A New Experimental Model for Assessing Drug Efficacy against Trypanosoma cruzi Infection Based on Highly Sensitive In Vivo Imaging.
Journal of biomolecular screening, 20 (1).
pp. 36-43.
ISSN 1087-0571
DOI: https://doi.org/10.1177/1087057114552623
Lewis, MD;
Kelly, JM;
(2016)
Putting Infection Dynamics at the Heart of Chagas Disease.
Trends in parasitology.
ISSN 1471-4922
DOI: https://doi.org/10.1016/j.pt.2016.08.009
Olmo, F;
Costa, FC;
Mann, GS;
Taylor, MC;
Kelly, JM;
(2018)
Optimising genetic transformation of Trypanosoma cruzi using hydroxyurea-induced cell-cycle synchronisation.
Molecular and biochemical parasitology.
ISSN 0166-6851
DOI: https://doi.org/10.1016/j.molbiopara.2018.07.002
Full text not available from this repository.
Richards, T;
Clevenger, B;
Keidan, J;
Collier, T;
Klein, AA;
Anker, SD;
Kelly, JD;
(2015)
PREVENTT: preoperative intravenous iron to treat anaemia in major surgery: study protocol for a randomised controlled trial.
Trials, 16 (1).
p. 254.
ISSN 1745-6215
DOI: https://doi.org/10.1186/s13063-015-0774-2
Sola, I;
Artigas, A;
Taylor, MC;
Gbedema, SY;
Pérez, B;
Clos, MV;
Wright, CW;
Kelly, JM;
Muñoz-Torrero, D;
(2014)
Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines.
Bioorganic & medicinal chemistry letters, 24 (23).
pp. 5435-5438.
ISSN 0960-894X
DOI: https://doi.org/10.1016/j.bmcl.2014.10.025
Full text not available from this repository.
Sola, I;
Artigas, A;
Taylor, MC;
Pérez-Areales, FJ;
Viayna, E;
Clos, MV;
Pérez, B;
Wright, CW;
Kelly, JM;
Muñoz-Torrero, D;
(2016)
Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents.
Bioorganic & medicinal chemistry.
ISSN 0968-0896
DOI: https://doi.org/10.1016/j.bmc.2016.08.036
Sola, I;
Castellà, S;
Viayna, E;
Galdeano, C;
Taylor, MC;
Gbedema, SY;
Pérez, B;
Clos, MV;
Jones, DC;
Fairlamb, AH;
+3 more...
Wright, CW;
Kelly, JM;
Muñoz-Torrero, D;
(2015)
Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity.
Bioorganic & medicinal chemistry, 23 (16).
pp. 5156-67.
ISSN 0968-0896
DOI: https://doi.org/10.1016/j.bmc.2015.01.031
Full text not available from this repository.
Taylor, MC;
Kelly, JM;
(2014)
Optimizing bioluminescence imaging to study protozoan parasite infections.
Trends in parasitology, 30 (4).
pp. 161-2.
ISSN 1471-4922
DOI: https://doi.org/10.1016/j.pt.2014.01.006
Full text not available from this repository.
Taylor, MC;
Lewis, MD;
Francisco, AF;
Wilkinson, SR;
Kelly, JM;
(2015)
The Trypanosoma cruzi Vitamin C Dependent Peroxidase Confers Protection against Oxidative Stress but Is Not a Determinant of Virulence.
PLoS neglected tropical diseases, 9 (4).
e0003707.
ISSN 1935-2727
DOI: https://doi.org/10.1371/journal.pntd.0003707
Wilkinson, SR;
Kelly, JM;
(2003)
The role of glutathione peroxidases in trypanosomatids.
Biological chemistry, 384 (4).
pp. 517-25.
ISSN 1431-6730
DOI: https://doi.org/10.1515/BC.2003.060
Full text not available from this repository.
Zoidis, G;
Tsotinis, A;
Tsatsaroni, A;
Taylor, MC;
Kelly, JM;
Efstathiou, A;
Smirlis, D;
Fytas, G;
(2017)
Lipophilic conformationally constrained spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acid analogues as trypanocidal and leishmanicidal agents: an extended SAR study.
Chemical biology & drug design.
ISSN 1747-0277
DOI: https://doi.org/10.1111/cbdd.13088
Book Section
Kelly, JM;
Taylor, MC;
Wilkinson, SR;
(2005)
Trypanosoma cruzi.
In: Fuchs, J; Podda, M; Goethe, JW, (eds.)
Encyclopedia of Diagnostic Genomics and Proteomics.
Marcel Dekker, Inc., New York, USA, pp. 1297-1301.
http://researchonline.lshtm.ac.uk/id/eprint/15644
Full text not available from this repository.
Renauld, H;
Kelly, JM;
Horn, D;
(2007)
Chromosome structure and dynamics.
In: Barry, D; Mottram, J; McCulloch, R; Acosta-Serrano, A; Renauld, H, (eds.)
Trypanosomes - After the Genome.
Horizon Scientific Press, Norwich, UK., pp. 91-132.
http://researchonline.lshtm.ac.uk/id/eprint/11566
Full text not available from this repository.