Items where Author is "Furnham, N"

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Number of items: 40.

2019

Tyzack, JD; Furnham, N; Sillitoe, I; Orengo, CM; Thornton, JM; (2019) Exploring Enzyme Evolution from Changes in Sequence, Structure, and Function. Methods in molecular biology (Clifton, NJ), 1851. pp. 263-275. ISSN 1064-3745 DOI: https://doi.org/10.1007/978-1-4939-8736-8_14 Full text not available from this repository.

2018

Coll, F; Phelan, J; Hill-Cawthorne, GA; Nair, MB; Mallard, K; Ali, S; Abdallah, AM; Alghamdi, S; Alsomali, M; Ahmed, AO; +41 more... Portelli, S; Oppong, Y; Alves, A; Bessa, TB; Campino, S; Caws, M; Chatterjee, A; Crampin, AC; Dheda, K; Furnham, N; Glynn, JR; Grandjean, L; Ha, DM; Hasan, R; Hasan, Z; Hibberd, ML; Joloba, M; Jones-López, EC; Matsumoto, T; Miranda, A; Moore, DJ; Mocillo, N; Panaiotov, S; Parkhill, J; Penha, C; Perdigão, J; Portugal, I; Rchiad, Z; Robledo, J; Sheen, P; Shesha, NT; Sirgel, FA; Sola, C; Sousa, EO; Streicher, EM; Van Helden, P; Viveiros, M; Warren, RM; McNerney, R; Pain, A; Clark, TG; (2018) Author Correction: Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis. Nature genetics. ISSN 1061-4036 DOI: https://doi.org/10.1038/s41588-018-0074-3 Full text not available from this repository.

Coll, F; Phelan, J; Hill-Cawthorne, GA; Nair, MB; Mallard, K; Ali, S; Abdallah, AM; Alghamdi, S; Alsomali, M; Ahmed, AO; +41 more... Portelli, S; Oppong, Y; Alves, A; Bessa, TB; Campino, S; Caws, M; Chatterjee, A; Crampin, AC; Dheda, K; Furnham, N; Glynn, JR; Grandjean, L; Minh Ha, D; Hasan, R; Hasan, Z; Hibberd, ML; Joloba, M; Jones-López, EC; Matsumoto, T; Miranda, A; Moore, DJ; Mocillo, N; Panaiotov, S; Parkhill, J; Penha, C; Perdigão, J; Portugal, I; Rchiad, Z; Robledo, J; Sheen, P; Shesha, NT; Sirgel, FA; Sola, C; Oliveira Sousa, E; Streicher, EM; Helden, PV; Viveiros, M; Warren, RM; McNerney, R; Pain, A; Clark, TG; (2018) Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis. Nature genetics. ISSN 1061-4036 DOI: https://doi.org/10.1038/s41588-017-0029-0
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Giuliani, S; Silva, AC; Borba, JVVB; Ramos, PIP; Paveley, RA; Muratov, EN; Andrade, CH; Furnham, N; (2018) Computationally-guided drug repurposing enables the discovery of kinase targets and inhibitors as new schistosomicidal agents. PLoS computational biology, 14 (10). e1006515. ISSN 1553-734X DOI: https://doi.org/10.1371/journal.pcbi.1006515 Full text not available from this repository.

2017

Furnham, N; (2017) Complementary Sources of Protein Functional Information: The Far Side of GO. In: UNSPECIFIED, (ed.) The Gene Ontology Handbook. Humana Press, pp. 263-274. ISBN 1940-6029 DOI: https://doi.org/10.1007/978-1-4939-3743-1_19
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Ribeiro, AJM; Holliday, GL; Furnham, N; Tyzack, JD; Ferris, K; Thornton, JM; (2017) Mechanism and Catalytic Site Atlas (M-CSA): a database of enzyme reaction mechanisms and active sites. Nucleic acids research. ISSN 0305-1048 DOI: https://doi.org/10.1093/nar/gkx1012
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Tyzack, JD; Furnham, N; Sillitoe, I; Orengo, CM; Thornton, JM; (2017) Understanding enzyme function evolution from a computational perspective. Current opinion in structural biology, 47. pp. 131-139. ISSN 0959-440X DOI: https://doi.org/10.1016/j.sbi.2017.08.003
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Valasatava, Y; Rosato, A; Furnham, N; Thornton, JM; Andreini, C; (2017) To what extent do structural changes in catalytic metal sites affect enzyme function? Journal of inorganic biochemistry, 179. pp. 40-53. ISSN 0162-0134 DOI: https://doi.org/10.1016/j.jinorgbio.2017.11.002
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2016

Mascotti, ML; Juri Ayub, M; Furnham, N; Thornton, JM; Laskowski, RA; (2016) Chopping and changing: The evolution of the flavin-dependent monooxygenases. Journal of molecular biology, 428 (15). pp. 3131-46. ISSN 0022-2836 DOI: https://doi.org/10.1016/j.jmb.2016.07.003
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Melo-Filho, CC; Dantas, RF; Braga, RC; Neves, BJ; Senger, MR; Valente, WC; Rezende-Neto, JM; Chaves, WT; Muratov, EN; Paveley, RA; +5 more... Furnham, N; Kamentsky, L; Carpenter, AE; Silva-Junior, FP; Andrade, CH; (2016) QSAR-Driven Discovery of Novel Chemical Scaffolds Active against Schistosoma mansoni. Journal of chemical information and modeling, 56 (7). pp. 1357-72. ISSN 1549-9596 DOI: https://doi.org/10.1021/acs.jcim.6b00055
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Neves, BJ; Dantas, RF; Senger, MR; Melo-Filho, CC; Valente, WC; de Almeida, AC; Rezende-Neto, JM; Lima, EF; Paveley, R; Furnham, N; +6 more... Muratov, E; Kamentsky, L; Carpenter, AE; Braga, RC; Silva-Junior, FP; Andrade, CH; (2016) Discovery of New Anti-Schistosomal Hits by Integration of QSAR-Based Virtual Screening and High Content Screening. Journal of medicinal chemistry, 59 (15). pp. 7075-88. ISSN 0022-2623 DOI: https://doi.org/10.1021/acs.jmedchem.5b02038
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Phelan, J; Coll, F; McNerney, R; Ascher, DB; Pires, DE; Furnham, N; Coeck, N; Hill-Cawthorne, GA; Nair, MB; Mallard, K; +6 more... Ramsay, A; Campino, S; Hibberd, ML; Pain, A; Rigouts, L; Clark, TG; (2016) Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance. BMC medicine, 14 (1). p. 31. ISSN 1741-7015 DOI: https://doi.org/10.1186/s12916-016-0575-9
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2015

Farnell, EJ; Tyagi, N; Ryan, S; Chalmers, IW; Pinot de Moira, A; Jones, FM; Wawrzyniak, J; Fitzsimmons, CM; Tukahebwa, EM; Furnham, N; +2 more... Maizels, RM; Dunne, DW; (2015) Known Allergen Structures Predict Schistosoma mansoni IgE-Binding Antigens in Human Infection. Frontiers in immunology, 6. p. 26. ISSN 1664-3224 DOI: https://doi.org/10.3389/fimmu.2015.00026
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Furnham, N; Dawson, NL; Rahman, SA; Thornton, JM; Orengo, CA; (2015) Large-Scale Analysis Exploring Evolution of Catalytic Machineries and Mechanisms in Enzyme Superfamilies. Journal of molecular biology, 428 (2 Pt A). pp. 253-67. ISSN 0022-2836 DOI: https://doi.org/10.1016/j.jmb.2015.11.010
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Martínez Cuesta, S; Rahman, SA; Furnham, N; Thornton, JM; (2015) The Classification and Evolution of Enzyme Function. Biophysical journal, 109 (6). pp. 1082-6. ISSN 0006-3495 DOI: https://doi.org/10.1016/j.bpj.2015.04.020
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Tyagi, N; Farnell, EJ; Fitzsimmons, CM; Ryan, S; Tukahebwa, E; Maizels, RM; Dunne, DW; Thornton, JM; Furnham, N; (2015) Comparisons of Allergenic and Metazoan Parasite Proteins: Allergy the Price of Immunity. PLoS computational biology, 11 (10). e1004546. ISSN 1553-734X DOI: https://doi.org/10.1371/journal.pcbi.1004546
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2014

Holliday, GL; Rahman, SA; Furnham, N; Thornton, JM; (2014) Exploring the biological and chemical complexity of the ligases. Journal of molecular biology, 426 (10). pp. 2098-111. ISSN 0022-2836 DOI: https://doi.org/10.1016/j.jmb.2014.03.008
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Martinez Cuesta, S; Furnham, N; Rahman, SA; Sillitoe, I; Thornton, JM; (2014) The evolution of enzyme function in the isomerases. Current opinion in structural biology, 26C. pp. 121-130. ISSN 0959-440X DOI: https://doi.org/10.1016/j.sbi.2014.06.002
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Rahman, SA; Cuesta, SM; Furnham, N; Holliday, GL; Thornton, JM; (2014) EC-BLAST: a tool to automatically search and compare enzyme reactions. Nature methods, 11 (2). pp. 171-4. ISSN 1548-7091 DOI: https://doi.org/10.1038/nmeth.2803
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Sillitoe, I; Lewis, TE; Cuff, A; Das, S; Ashford, P; Dawson, NL; Furnham, N; Laskowski, RA; Lee, D; Lees, JG; +4 more... Lehtinen, S; Studer, RA; Thornton, J; Orengo, CA; (2014) CATH: comprehensive structural and functional annotations for genome sequences. Nucleic acids research. ISSN 0305-1048 DOI: https://doi.org/10.1093/nar/gku947
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2013

Furnham, N; Holliday, GL; de Beer, TA; Jacobsen, JO; Pearson, WR; Thornton, JM; (2013) The Catalytic Site Atlas 2.0: cataloging catalytic sites and residues identified in enzymes. Nucleic acids research, 42 (Databa). D485-9. ISSN 0305-1048 DOI: https://doi.org/10.1093/nar/gkt1243
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Furnham, N; Laskowski, RA; Thornton, JM; (2013) Abstracting knowledge from the protein data bank. Biopolymers, 99 (3). pp. 183-8. ISSN 0006-3525 DOI: https://doi.org/10.1002/bip.22107 Full text not available from this repository.

2012

Furnham, N; Sillitoe, I; Holliday, GL; Cuff, AL; Laskowski, RA; Orengo, CA; Thornton, JM; (2012) Exploring the evolution of novel enzyme functions within structurally defined protein superfamilies. PLoS computational biology, 8 (3). e1002403. ISSN 1553-734X DOI: https://doi.org/10.1371/journal.pcbi.1002403
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Furnham, N; de Beer, TA; Thornton, JM; (2012) Current challenges in genome annotation through structural biology and bioinformatics. Current opinion in structural biology, 22 (5). pp. 594-601. ISSN 0959-440X DOI: https://doi.org/10.1016/j.sbi.2012.07.005 Full text not available from this repository.

Sillitoe, I; Cuff, AL; Dessailly, BH; Dawson, NL; Furnham, N; Lee, D; Lees, JG; Lewis, TE; Studer, RA; Rentzsch, R; +3 more... Yeats, C; Thornton, JM; Orengo, CA; (2012) New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures. Nucleic acids research, 41 (Databa). D490-8. ISSN 0305-1048 DOI: https://doi.org/10.1093/nar/gks1211
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2011

Furnham, N; Sillitoe, I; Holliday, GL; Cuff, AL; Rahman, SA; Laskowski, RA; Orengo, CA; Thornton, JM; (2011) FunTree: a resource for exploring the functional evolution of structurally defined enzyme superfamilies. Nucleic acids research, 40 (Databa). D776-82. ISSN 0305-1048 DOI: https://doi.org/10.1093/nar/gkr852
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2010

Cuff, AL; Sillitoe, I; Lewis, T; Clegg, AB; Rentzsch, R; Furnham, N; Pellegrini-Calace, M; Jones, D; Thornton, J; Orengo, CA; (2010) Extending CATH: increasing coverage of the protein structure universe and linking structure with function. Nucleic acids research, 39 (Databa). D420-6. ISSN 0305-1048 DOI: https://doi.org/10.1093/nar/gkq1001
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2009

Furnham, N; Garavelli, JS; Apweiler, R; Thornton, JM; (2009) Missing in action: enzyme functional annotations in biological databases. Nature chemical biology, 5 (8). pp. 521-5. ISSN 1552-4450 DOI: https://doi.org/10.1038/nchembio0809-521 Full text not available from this repository.

Karmali, AM; Blundell, TL; Furnham, N; (2009) Model-building strategies for low-resolution X-ray crystallographic data. Acta crystallographica Section D, Biological crystallography, 65 (Pt 2). pp. 121-7. ISSN 0907-4449 DOI: https://doi.org/10.1107/S0907444908040006
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2008

Bavro, VN; Pietras, Z; Furnham, N; Pérez-Cano, L; Fernández-Recio, J; Pei, XY; Misra, R; Luisi, B; (2008) Assembly and channel opening in a bacterial drug efflux machine. Molecular cell, 30 (1). pp. 114-21. ISSN 1097-2765 DOI: https://doi.org/10.1016/j.molcel.2008.02.015
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Furnham, N; de Bakker, PI; Gore, S; Burke, DF; Blundell, TL; (2008) Comparative modelling by restraint-based conformational sampling. BMC Struct Biol, 8. p. 7. ISSN 1472-6807 DOI: https://doi.org/10.1186/1472-6807-8-7
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Pietras, Z; Bavro, VN; Furnham, N; Pellegrini-Calace, M; Milner-White, EJ; Luisi, BF; (2008) Structure and mechanism of drug efflux machinery in Gram negative bacteria. Current drug targets, 9 (9). pp. 719-28. ISSN 1389-4501 http://researchonline.lshtm.ac.uk/id/eprint/2551706 Full text not available from this repository.

Ragone, S; Maman, JD; Furnham, N; Pellegrini, L; (2008) Structural basis for inhibition of homologous recombination by the RecX protein. The EMBO journal, 27 (16). pp. 2259-69. ISSN 0261-4189 DOI: https://doi.org/10.1038/emboj.2008.145
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2006

Doré, AS; Furnham, N; Davies, OR; Sibanda, BL; Chirgadze, DY; Jackson, SP; Pellegrini, L; Blundell, TL; (2006) Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode. DNA repair, 5 (3). pp. 362-8. ISSN 1568-7864 DOI: https://doi.org/10.1016/j.dnarep.2005.11.004 Full text not available from this repository.

Furnham, N; Blundell, TL; DePristo, MA; Terwilliger, TC; (2006) Is one solution good enough? Nature structural & molecular biology, 13 (3). 184-5; discussion 185. ISSN 1545-9993 DOI: https://doi.org/10.1038/nsmb0306-184 Full text not available from this repository.

Furnham, N; Doré, AS; Chirgadze, DY; de Bakker, PI; Depristo, MA; Blundell, TL; (2006) Knowledge-based real-space explorations for low-resolution structure determination. Structure (London, England, 14 (8). pp. 1313-20. ISSN 0969-2126 DOI: https://doi.org/10.1016/j.str.2006.06.014 Full text not available from this repository.

de Bakker, PI; Furnham, N; Blundell, TL; DePristo, MA; (2006) Conformer generation under restraints. Current opinion in structural biology, 16 (2). pp. 160-5. ISSN 0959-440X DOI: https://doi.org/10.1016/j.sbi.2006.02.001 Full text not available from this repository.

2004

Furnham, N; Ruffle, S; Southan, C; (2004) Splice variants: a homology modeling approach. Proteins, 54 (3). pp. 596-608. ISSN 0887-3585 DOI: https://doi.org/10.1002/prot.10568 Full text not available from this repository.

This list was generated on Tue Nov 27 09:12:03 2018 GMT.