Glover, L; Alsford, S; Baker, N; Turner, DJ; Sanchez-Flores, A; Hutchinson, S; Hertz-Fowler, C; Berriman, M; Horn, D; (2014) Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes. Nature protocols, 10 (1). pp. 106-133. ISSN 1754-2189 DOI: https://doi.org/10.1038/nprot.2015.005 Full text not available from this repository.

Alsford, S; Field, MC; Horn, D; (2013) Receptor-mediated endocytosis for drug delivery in African trypanosomes: fulfilling Paul Ehrlich's vision of chemotherapy. Trends in parasitology. ISSN 1471-4922 DOI: https://doi.org/10.1016/j.pt.2013.03.004 Full text not available from this repository.

Alsford, S; Kelly, JM; Baker, N; Horn, D; (2013) Genetic dissection of drug resistance in trypanosomes. Parasitology. pp. 1-14. ISSN 0031-1820 DOI: https://doi.org/10.1017/S003118201300022X

Baker, N; de Koning, HP; Mäser, P; Horn, D; (2013) Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story. Trends in parasitology. ISSN 1471-4922 DOI: https://doi.org/10.1016/j.pt.2012.12.005

Glover, L; Alsford, S; Horn, D; (2013) DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in african trypanosomes. PLoS pathogens, 9 (3). e1003260. ISSN 1553-7366 DOI: https://doi.org/10.1371/journal.ppat.1003260

Glover, L; Hutchinson, S; Alsford, S; McCulloch, R; Field, MC; Horn, D; (2013) Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control. Cellular microbiology, 15 (12). pp. 1984-93. ISSN 1462-5814 DOI: https://doi.org/10.1111/cmi.12215 Full text not available from this repository.

Gould, MK; Bachmaier, S; Ali, JA; Alsford, S; Tagoe, DN; Munday, JC; Schnaufer, AC; Horn, D; Boshart, M; de Koning, HP; (2013) Cyclic AMP Effectors in African Trypanosomes Revealed by Genome-Scale RNA Interference Library Screening for Resistance to the Phosphodiesterase Inhibitor CpdA. Antimicrobial agents and chemotherapy, 57 (10). pp. 4882-93. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.00508-13

Horn, D; (2013) High-throughput decoding of drug targets and drug resistance mechanisms in African trypanosomes. Parasitology. pp. 1-6. ISSN 0031-1820 DOI: https://doi.org/10.1017/S0031182013000243

LSHTM; (2012) Multi-Tasking Gene Analyser Boosts Trypanosomiasis Treatment Hopes - 26 Jan 2012. [Podcast] http://soundcloud.com/lshtm/multi-tasking-gene-ana...

Alsford, S; Dubois, K; Horn, D; Field, MC; (2012) Epigenetic mechanisms, nuclear architecture and the control of gene expression in trypanosomes. Expert reviews in molecular medicine, 14. e13. ISSN 1462-3994 DOI: https://doi.org/10.1017/erm.2012.7 Full text not available from this repository.

Alsford, S; Eckert, S; Baker, N; Glover, L; Sanchez-Flores, A; Leung, KF; Turner, DJ; Field, MC; Berriman, M; Horn, D; (2012) High-throughput decoding of antitrypanosomal drug efficacy and resistance. Nature, 482 (7384). pp. 232-6. ISSN 0028-0836 DOI: https://doi.org/10.1038/nature10771

Alsford, S; Horn, D; (2012) Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei. Nucleic acids research, 40 (20). pp. 10150-60. ISSN 0305-1048 DOI: https://doi.org/10.1093/nar/gks813

Baker, N; Glover, L; Munday, JC; Aguinaga Andrés, D; Barrett, MP; de Koning, HP; Horn, D; (2012) Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424 DOI: https://doi.org/10.1073/pnas.1202885109 Full text not available from this repository.

DuBois, KN; Alsford, S; Holden, JM; Buisson, J; Swiderski, M; Bart, JM; Ratushny, AV; Wan, Y; Bastin, P; Barry, JD; +5 more... Navarro, M; Horn, D; Aitchison, JD; Rout, MP; Field, MC; (2012) NUP-1 Is a Large Coiled-Coil Nucleoskeletal Protein in Trypanosomes with Lamin-Like Functions. PLoS biology, 10 (3). e1001287. ISSN 1544-9173 DOI: https://doi.org/10.1371/journal.pbio.1001287

Field, MC; Horn, D; Alsford, S; Koreny, L; Rout, MP; (2012) Telomeres, tethers and trypanosomes. Nucleus (Austin, Tex), 3 (6). pp. 478-486. ISSN 1949-1034 DOI: https://doi.org/10.4161/nucl.22167

Glover, L; Horn, D; (2012) Trypanosomal histone ?H2A and the DNA damage response. Molecular and biochemical parasitology. ISSN 0166-6851 DOI: https://doi.org/10.1016/j.molbiopara.2012.01.008

Kelly, JM; Taylor, MC; Horn, D; Loza, E; Kalvinsh, I; Björkling, F; (2012) Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei. Bioorganic & medicinal chemistry letters, 22 (5). pp. 1886-90. ISSN 0960-894X DOI: https://doi.org/10.1016/j.bmcl.2012.01.072

Alsford, S; Horn, D; (2011) Elongator Protein 3b Negatively Regulates Ribosomal DNA Transcription in African Trypanosomes. Molecular and cellular biology, 31 (9). pp. 1822-32. ISSN 0270-7306 DOI: https://doi.org/10.1128/MCB.01026-10

Alsford, S; Turner, DJ; Obado, SO; Sanchez-Flores, A; Glover, L; Berriman, M; Hertz-Fowler, C; Horn, D; (2011) High throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome. Genome research, 21 (6). pp. 915-24. ISSN 1088-9051 DOI: https://doi.org/10.1101/gr.115089.110

Alsford, S; Kemp, LE; Kawahara, T; Horn, D; (2010) RNA interference, growth and differentiation appear normal in African trypanosomes lacking Tudor staphylococcal nuclease. Molecular and biochemical parasitology, 174 (1). pp. 70-3. ISSN 0166-6851 DOI: https://doi.org/10.1016/j.molbiopara.2010.06.006

Baker, N; Alsford, S; Horn, D; (2010) Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6. Molecular and biochemical parasitology. ISSN 0166-6851 DOI: https://doi.org/10.1016/j.molbiopara.2010.11.010

Glover, L; Jun, J; Horn, D; (2010) Microhomology-mediated deletion and gene conversion in African trypanosomes. Nucleic acids research. ISSN 0305-1048 DOI: https://doi.org/10.1093/nar/gkq981

Horn, D; McCulloch, R; (2010) Molecular mechanisms underlying the control of antigenic variation in African trypanosomes. Current opinion in microbiology. ISSN 1369-5274 DOI: https://doi.org/10.1016/j.mib.2010.08.009

Wang, QP; Kawahara, T; Horn, D; (2010) Histone deacetylases play distinct roles in telomeric VSG expression site silencing in African trypanosomes. Molecular microbiology, 77 (5). pp. 1237-45. ISSN 0950-382X DOI: https://doi.org/10.1111/j.1365-2958.2010.07284.x

Alsford, S; Horn, D; Glover, L; (2009) DNA breaks as triggers for antigenic variation in African trypanosomes. Genome biology, 10 (6). p. 223. ISSN 1465-6906 DOI: https://doi.org/10.1186/gb-2009-10-6-223

Glover, L; Horn, D; (2009) Site-specific DNA double-strand breaks greatly increase stable transformation efficiency in Trypanosoma brucei. Molecular and biochemical parasitology, 166 (2). pp. 194-7. ISSN 0166-6851 DOI: https://doi.org/10.1016/j.molbiopara.2009.03.010

Horn, D; (2009) Antigenic variation: extending the reach of telomeric silencing. Current biology, 19 (12). R496-8. ISSN 0960-9822 DOI: https://doi.org/10.1016/j.cub.2009.04.049 Full text not available from this repository.

Alsford, S; Horn, D; (2008) Single-locus targeting constructs for reliable regulated RNAi and transgene expression in Trypanosoma brucei. Molecular and biochemical parasitology, 161 (1). pp. 76-9. ISSN 0166-6851 DOI: https://doi.org/10.1016/j.molbiopara.2008.05.006

Field, MC; Horn, D; Carrington, M; (2008) Analysis of small GTPase function in trypanosomes. In: Balch, WE; Der, CJ; Hall, A, (eds.) Small GTPases in Disease, Part A. Elsevier Academic Press Inc, San Diego, pp. 57-76. ISBN 9780123739681 DOI: https://doi.org/10.1016/S0076-6879(07)38005-1 Full text not available from this repository.

Glover, L; McCulloch, R; Horn, D; (2008) Sequence homology and microhomology dominate chromosomal double-strand break repair in African trypanosomes. Nucleic acids research, 36 (8). pp. 2608-18. ISSN 0305-1048 DOI: https://doi.org/10.1093/nar/gkn104

Horn, D; (2008) Histone deacetylases. Advances in experimental medicine and biology, 625. pp. 81-6. ISSN 0065-2598 http://researchonline.lshtm.ac.uk/id/eprint/8082 Full text not available from this repository.

Horn, D; (2008) Codon usage suggests that translational selection has a major impact on protein expression in trypanosomatids. BMC genomics, 9. p. 2. ISSN 1471-2164 DOI: https://doi.org/10.1186/1471-2164-9-2

Kawahara, T; Siegel, TN; Ingram, AK; Alsford, S; Cross, GA; Horn, D; (2008) Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes. Molecular microbiology, 69 (4). pp. 1054-68. ISSN 0950-382X DOI: https://doi.org/10.1111/j.1365-2958.2008.06346.x

Siegel, TN; Kawahara, T; Degrasse, JA; Janzen, CJ; Horn, D; Cross, GAM; (2008) Acetylation of histone H4K4 is cell cycle regulated and mediated by HAD in Trypanosoma brucei. Molecular microbiology, 67 (4). pp. 762-771. ISSN 0950-382X DOI: https://doi.org/10.1111/j.1365-2958.2007.06079.x

Wilkinson, SR; Taylor, MC; Horn, D; Kelly, JM; Cheeseman, I; (2008) A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes. Proceedings of the National Academy of Sciences of the United States of America, 105 (13). pp. 5022-7. ISSN 0027-8424 DOI: https://doi.org/10.1073/pnas.0711014105 Full text not available from this repository.

Alsford, S; Horn, D; (2007) RNA polymerase I transcription stimulates homologous recombination in Trypanosoma brucei. Molecular and biochemical parasitology, 153 (1). pp. 77-9. ISSN 0166-6851 DOI: https://doi.org/10.1016/j.molbiopara.2007.01.013

Alsford, S; Kawahara, T; Isamah, C; Horn, D; (2007) A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation. Molecular microbiology, 63 (3). pp. 724-36. ISSN 0950-382X DOI: https://doi.org/10.1111/j.1365-2958.2006.05553.x

Glover, L; Alsford, S; Beattie, C; Horn, D; (2007) Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest. Nucleic acids research, 35 (3). pp. 872-80. ISSN 0305-1048 DOI: https://doi.org/10.1093/nar/gkl1100

Horn, D; (2007) Introducing histone modification in trypanosomes. Trends in parasitology, 23 (6). pp. 239-42. ISSN 1471-4922 DOI: https://doi.org/10.1016/j.pt.2007.03.009 Full text not available from this repository.

Prathalingham, SR; Wilkinson, SR; Horn, D; Kelly, JM; (2007) Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole. Antimicrobial agents and chemotherapy, 51 (2). pp. 755-758. ISSN 0066-4804 DOI: https://doi.org/10.1128/aac.01360-06 Full text not available from this repository.

Prathalingham, SR; Wilkinson, SR; Horn, D; Kelly, JM; (2007) Deletion of the Trypanosoma brucei superoxide dismutase gene sodb1 increases sensitivity to nifurtimox and benznidazole. Antimicrobial agents and chemotherapy, 51 (2). pp. 755-8. ISSN 0066-4804 DOI: https://doi.org/10.1128/AAC.01360-06 Full text not available from this repository.

Renauld, H; Kelly, JM; Horn, D; (2007) Chromosome structure and dynamics. In: Barry, D; Mottram, J; McCulloch, R; Acosta-Serrano, A; Renauld, H, (eds.) Trypanosomes - After the Genome. Horizon Scientific Press, Norwich, UK., pp. 91-132. http://researchonline.lshtm.ac.uk/id/eprint/11566 Full text not available from this repository.

Glover, L; Horn, D; (2006) Repression of polymerase I-mediated gene expression at Trypanosoma brucei telomeres. EMBO reports, 7 (1). pp. 93-9. ISSN 1469-221X DOI: https://doi.org/10.1038/sj.embor.7400575 Full text not available from this repository.

Subramaniam, C; Veazey, P; Seth, R; Hayes-Sinclair, J; Chambers, E; Carrington, M; Gull, K; Matthews, K; Horn, D; Field, MC; (2006) Chromosome-wide analysis of gene function by RNA interference in the African trypanosome. Eukaryotic cell, 5 (9). pp. 1539-1549. ISSN 1535-9778 DOI: https://doi.org/10.1128/EC.00141-06 Full text not available from this repository.

Wilkinson, SR; Prathalingam, SR; Taylor, MC; Ahmed, A; Horn, D; Kelly, JM; (2006) Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei. Free radical biology & medicine, 40 (2). pp. 198-209. ISSN 0891-5849 DOI: https://doi.org/10.1016/j.freeradbiomed.2005.06.022 Full text not available from this repository.

Alibu, VP; Storm, L; Haile, S; Clayton, C; Horn, D; (2005) A doubly inducible system for RNA interference and rapid RNAi plasmid construction in Trypanosoma brucei. Molecular and biochemical parasitology. p. 75. ISSN 0166-6851 DOI: https://doi.org/10.1016/j.molbiopara.2004.10.002 Full text not available from this repository.

Alsford, S; Glover, L; Horn, D; (2005) Multiplex analysis of RNA interference defects in Trypanosoma brucei. Molecular and biochemical parasitology, 139 (1). pp. 129-32. ISSN 0166-6851 DOI: https://doi.org/10.1016/j.molbiopara.2004.11.001

Alsford, S; Kawahara, T; Glover, L; Horn, D; (2005) Tagging a T. brucei RRNA locus improves stable transfection efficiency and circumvents inducible expression position effects. Molecular and biochemical parasitology, 144 (2). pp. 142-8. ISSN 0166-6851 DOI: https://doi.org/10.1016/j.molbiopara.2005.08.009

Clayton, CE; Esteacutevez, AM; Hartmann, C; Alibu, VP; Field, M; Horn, D; (2005) Down-regulating gene expression by RNA interference in Trypanosoma brucei. Methods in molecular biology (Clifton, NJ), 309. pp. 39-60. ISSN 1064-3745 DOI: https://doi.org/10.1385/1-59259-935-4:039 Full text not available from this repository.

Horn, D; (2005) Directional enrichment of directly cloned PCR products. BioTechniques, 39 (1). 40, 42, 44, 46. ISSN 0736-6205 DOI: https://doi.org/10.2144/05391BM03 Full text not available from this repository.

Horn, D; Barry, JD; (2005) The central roles of telomeres and subtelomeres in antigenic variation in African trypanosomes. Chromosome research, 13 (5). pp. 525-33. ISSN 0967-3849 DOI: https://doi.org/10.1007/s10577-005-0991-8 Full text not available from this repository.

Ivens, AC; Peacock, CS; Worthey, EA; Murphy, L; Aggarwal, G; Berriman, M; Sisk, E; Rajandream, MA; Adlem, E; Aert, R; +90 more... Anupama, A; Apostolou, Z; Attipoe, P; Bason, N; Bauser, C; Beck, A; Beverley, SM; Bianchettin, G; Borzym, K; Bothe, G; Bruschi, CV; Collins, M; Cadag, E; Ciarloni, L; Clayton, C; Coulson, RMR; Cronin, A; Cruz, AK; Davies, RM; de Gaudenzi, J; Dobson, DE; Duesterhoeft, A; Fazelina, G; Fosker, N; Frasch, AC; Fraser, A; Fuchs, M; Gabel, C; Goble, A; Goffeau, A; Harris, D; Hertz-Fowler, C; Hilbert, H; Horn, D; Huang, YT; Klages, S; Knights, A; Kube, M; Larke, N; Litvin, L; Lord, A; Louie, T; Marra, M; Masuy, D; Matthews, K; Michaeli, S; Mottram, JC; Muller-Auer, S; Munden, H; Norbertczak, H; Oliver, K; O'Neil, S; Pentony, M; Pohl, TM; Price, C; Purnelle, B; Quail, MA; Rabbinowitsch, E; Reinhardt, R; Rieger, M; Rinta, J; Robben, J; Robertson, L; Ruiz, JC; Rutter, S; Saunders, D; Schafer, M; Schein, J; Schwartz, DC; Seeger, K; Seyler, A; Sharp, S; Shin, H; Sivam, D; Squares, R; Squares, S; Tosato, V; Vogt, C; Volckaert, G; Wambutt, R; Warren, T; Wedler, H; Woodward, J; Zhou, SG; Zimmermann, W; Smith, DF; Blackwell, JM; Stuart, KD; Barrell, B; Myler, PJ; (2005) The genome of the kinetoplastid parasite, Leishmania major. Science (New York, NY), 309 (5733). p. 436. ISSN 0036-8075 DOI: https://doi.org/10.1126/science.1112680 Full text not available from this repository.

Wilkinson, SR; Prathalingam, SR; Taylor, MC; Horn, D; Kelly, JM; (2005) Vitamin C biosynthesis in trypanosomes: A role for the glycosome. Proceedings of the National Academy of Sciences of the United States of America, 102. pp. 11645-11650. ISSN 0027-8424 DOI: https://doi.org/10.1073/pnas.0504251102 Full text not available from this repository.

el-Sayed, NM; Myler, PJ; Bartholomeu, DC; Nilsson, D; Aggarwal, G; Tran, AN; Ghedin, E; Worthey, EA; Delcher, AL; Blandin, G; +72 more... Westenberger, SJ; Caler, E; Cerqueira, GC; Branche, C; Haas, B; Anupama, A; Arner, E; Aslund, L; Attipoe, P; Bontempi, E; Bringaud, F; Burton, P; Cadag, E; Campbell, DA; Carrington, M; Crabtree, J; Darban, H; da Silveira, JF; de Jong, P; Edwards, K; Englund, PT; Fazelina, G; Feldblyum, T; Ferella, M; Frasch, AC; Gull, K; Horn, D; Hou, LH; Huang, YT; Kindlund, E; Ktingbeil, M; Kluge, S; Koo, H; Lacerda, D; Levin, MJ; Lorenzi, H; Louie, T; Machado, CR; McCulloch, R; McKenna, A; Mizuno, Y; Mottram, JC; Nelson, S; Ochaya, S; Osoegawa, K; Pai, G; Parsons, M; Pentony, M; Pettersson, U; Pop, M; Ramirez, JL; Rinta, J; Robertson, L; Salzberg, SL; Sanchez, DO; Seyler, A; Sharma, R; Shetty, J; Simpson, AJ; Sisk, E; Tammi, MT; Tarteton, R; Teixeira, S; van Aken, S; Vogt, C; Ward, PN; Wickstead, B; Wortman, J; White, O; Fraser, CM; Stuart, KD; Andersson, B; (2005) The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. Science (New York, NY), 309 (5733). p. 409. ISSN 0036-8075 DOI: https://doi.org/10.1126/science.1112631 Full text not available from this repository.

Alsford, S; Horn, D; (2004) Trypanosomatid histones. Molecular microbiology, 53 (2). pp. 365-72. ISSN 0950-382X DOI: https://doi.org/10.1111/j.1365-2958.2004.04151.x Full text not available from this repository.

Horn, D; (2004) The molecular control of antigenic variation in Trypanosoma brucei. Current molecular medicine, 4 (6). pp. 563-76. ISSN 1566-5240 DOI: https://doi.org/10.2174/1566524043360078 Full text not available from this repository.

Wilkinson, SR; Horn, D; Prathalingam, R; Kelly, JM; (2003) RNAi identifies two hydroperoxide metabolising enzymes that are essential to the bloodstream form of the African trypanosome. The Journal of biological chemistry, 278 (34). pp. 31640-6. ISSN 0021-9258 DOI: https://doi.org/10.1074/jbc.M303035200 Full text not available from this repository.

Ingram, AK; Horn, D; (2002) Histone deacetylases in Trypanosoma brucei: two are essential and another is required for normal cell cycle progression. Molecular microbiology, 45 (1). pp. 89-97. ISSN 0950-382X DOI: https://doi.org/10.1046/j.1365-2958.2002.03018.x Full text not available from this repository.

Horn, D; (2001) Nuclear gene transcription and chromatin in Trypanosoma brucei. International journal for parasitology, 31 (11). pp. 1157-65. ISSN 0020-7519 http://researchonline.lshtm.ac.uk/id/eprint/17258 Full text not available from this repository.