Cyclin E immunoexpression in breast ductal carcinoma: pathologic correlations and prognostic implications.
Donnellan, R;
Kleinschmidt, I;
Chetty, R;
(2001)
Cyclin E immunoexpression in breast ductal carcinoma: pathologic correlations and prognostic implications.
Human pathology, 32 (1).
pp. 89-94.
ISSN 0046-8177
DOI: https://doi.org/10.1053/hupa.2001.21141
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Abnormalities of the cell cycle are present in all neoplasms. Cyclin E, which regulates the G1/S phase transition of the cell cycle, plays an important role in many different cancers. To further investigate the role of cyclin E in invasive breast ductal carcinomas in South African women, representative sections from 157 mastectomy and axillary clearance specimens were stained with the cyclin E antibody. The results were compared with known clinicopathologic prognostic factors, namely lymph node metastases, size, estrogen receptor status, and histologic grade. Positive (nuclear) cyclin E immunostaining strongly correlates with negative estrogen receptor status and high grade. These correlations may account for the observation that although cyclin E staining is associated with poor prognosis in univariate analysis, no prognostic significance remains after multivariate analysis.