Identification of CRF10_CD viruses among bar and hotel workers in Moshi, Northern Tanzania.
Kiwelu, Ireen E;
Koulinska, Irene N;
Nkya, Watoky MMM;
Shao, John;
Kapiga, Saidi;
Essex, Max;
(2005)
Identification of CRF10_CD viruses among bar and hotel workers in Moshi, Northern Tanzania.
AIDS research and human retroviruses, 21 (10).
pp. 897-900.
ISSN 0889-2229
DOI: https://doi.org/10.1089/aid.2005.21.897
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We recently identified an HIV-1 subtype C and D circulating recombinant form (CRF10_CD) in infants in Dar es Salaam, Tanzania. So far, this is the only reported HIV-1 CRF in East Africa. However, evidence for its spread in the adult population is scarce. Here we describe the presence of CRF10_CD in two asymptomatic bar and hotel workers in Moshi, Northern Tanzania. Subgenomic sequences from gag (3'p24-5'p7), env (C2-C5), and the 5' LTR were used for phylogenetic analysis and identification of recombination. Genetic divergence between the CRF10_CD sequences from Moshi suggested that they were contracted from independent sources. A third bar worker was infected with an apparent CRF10_CD/subtype A recombinant virus. Our data indicate that CRF10_CD genomes can be transmitted both vertically and heterosexually.
