Genome of the host-cell transforming parasite Theileria annulata compared with T. parva.
Arnab
Pain
;
Hubert
Renauld
;
Matthew
Berriman
;
Lee
Murphy
;
Corin A
Yeats
;
William
Weir
;
Arnaud
Kerhornou
;
Martin
Aslett
;
Richard
Bishop
;
Christiane
Bouchier
;
+40 more...
Madeleine
Cochet
;
Richard MR
Coulson
;
Ann
Cronin
;
Etienne P
de Villiers
;
Audrey
Fraser
;
Nigel
Fosker
;
Malcolm
Gardner
;
Arlette
Goble
;
Sam
Griffiths-Jones
;
David E
Harris
;
Frank
Katzer
;
Natasha
Larke
;
Angela
Lord
;
Pascal
Maser
;
Sue
McKellar
;
Paul
Mooney
;
Fraser
Morton
;
Vishvanath
Nene
;
Susan
O'Neil
;
Claire
Price
;
Michael A
Quail
;
Ester
Rabbinowitsch
;
Neil D
Rawlings
;
Simon
Rutter
;
David
Saunders
;
Kathy
Seeger
;
Trushar
Shah
;
Robert
Squares
;
Steven
Squares
;
Adrian
Tivey
;
Alan R
Walker
;
John
Woodward
;
Dirk AE
Dobbelaere
;
Gordon
Langsley
;
Marie-Adele
Rajandream
;
Declan
McKeever
;
Brian
Shiels
;
Andrew
Tait
;
Bart
Barrell
;
Neil
Hall
;
(2005)
Genome of the host-cell transforming parasite Theileria annulata compared with T. parva.
Science (New York, NY), 309 (5731).
pp. 131-133.
ISSN 0036-8075
DOI: 10.1126/science.1110418
Theileria annulata and T. parva are closely related protozoan parasites that cause lymphoproliferative diseases of cattle. We sequenced the genome of T. annulata and compared it with that of T. parva to understand the mechanisms underlying transformation and tropism. Despite high conservation of gene sequences and synteny, the analysis reveals unequally expanded gene families and species-specific genes. We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host-cell transformation, and a Theileria-specific protein domain [frequently associated in Theileria (FAINT)] present in a large number of secreted proteins.
| Item Type | Article |
|---|---|
| ISI | 230212800075 |
| Date Deposited | 17 Oct 2011 17:51 |