IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages.
Carvalho, Luzia H;
Sano, Gen-Ichiro;
Hafalla, Julius CR;
Morrot, Alexandre;
Curotto de Lafaille, Maria A;
Zavala, Fidel;
(2002)
IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages.
Nature medicine, 8 (2).
pp. 166-170.
ISSN 1078-8956
DOI: https://doi.org/10.1038/nm0202-166
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CD4+ T cells are crucial to the development of CD8+ T cell responses against hepatocytes infected with malaria parasites. In the absence of CD4+ T cells, CD8+ T cells initiate a seemingly normal differentiation and proliferation during the first few days after immunization. However, this response fails to develop further and is reduced by more than 90%, compared to that observed in the presence of CD4+ T cells. We report here that interleukin-4 (IL-4) secreted by CD4+ T cells is essential to the full development of this CD8+ T cell response. This is the first demonstration that IL-4 is a mediator of CD4/CD8 cross-talk leading to the development of immunity against an infectious pathogen.
