Bong, C-N; Chen, SCC; Jong, Y-J; Tok, T-S; Hsu, C-F; Schouten, EJ; Makombe, SD; Yu, JK-L; Harries, AD; (2007) Outcomes of HIV-infected children with tuberculosis who are started on antiretroviral therapy in Malawi. The international journal of tuberculosis and lung disease, 11 (5). pp. 534-538. ISSN 1027-3719 https://researchonline.lshtm.ac.uk/id/eprint/9724
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https://researchonline.lshtm.ac.uk/id/eprint/9724
Abstract
SETTING: Mzuzu Central Hospital, in the northern region of Malawi, which provides free antiretroviral therapy (ART) to human immunodeficiency virus (HIV) infected adults and children, including those with tuberculosis (TB). OBJECTIVES: To compare outcomes in HIV-infected children who have been started on ART because of 1) active TB, 2) a past history of TB in the last 2 years and 3) a non-TB diagnosis. DESIGN: Retrospective data collection using ART patient master cards and ART patient registers. RESULTS: Between July 2004 and September 2006, 439 (11%) children of a total 3908 patients were started on ART. There were 29 with active TB, 56 with a past history of TB in the last 2 years and 354 with a non-TB diagnosis. The three groups were similar in nutritional indices and CD4-lymphocyte percentages. The 6-month probability of survival was 0.86 in the active TB group, 0.94 in the past history of TB group and 0.89 in the non-TB group. 12-month survival probability for the same groups was 0.86, 0.86 and 0.88, respectively. CONCLUSION: HIV-infected children with active and previous TB who are started on ART have good outcomes that are similar to those of children started on ART due to a non-TB diagnosis.
Item Type | Article |
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Keywords | TB, children, antiretroviral therapy, treatment outcomes, Malawi, EARLY MORTALITY, COTE-DIVOIRE, SOUTH-AFRICA, ADULTS, ERA, NEVIRAPINE, ABIDJAN, DISEASE, Adolescent, Anti-HIV Agents, therapeutic use, Antitubercular Agents, therapeutic use, Child, Child, Preschool, Female, Follow-Up Studies, HIV Infections, complications, drug therapy, mortality, Humans, Infant, Malawi, Male, Retrospective Studies, Survival Rate, Treatment Outcome, Tuberculosis, complications, drug therapy |
Faculty and Department | Faculty of Infectious and Tropical Diseases > Dept of Clinical Research |
PubMed ID | 17439677 |
ISI | 245913500011 |