Frayling, Timothy M; Timpson, Nicholas J; Weedon, Michael N; Zeggini, Eleftheria; Freathy, Rachel M; Lindgren, Cecilia M; Perry, John RB; Elliott, Katherine S; Lango, Hana; Rayner, Nigel W; +31 more... Shields, Beverley; Harries, Lorna W; Barrett, Jeffrey C; Ellard, Sian; Groves, Christopher J; Knight, Bridget; Patch, Ann-Marie; Ness, Andrew R; Ebrahim, Shah; Lawlor, Debbie A; Ring, Susan M; Ben-Shlomo, Yoav; Jarvelin, Marjo-Riitta; Sovio, Ulla; Bennett, Amanda J; Melzer, David; Ferrucci, Luigi; Loos, Ruth JF; Barroso, Inês; Wareham, Nicholas J; Karpe, Fredrik; Owen, Katharine R; Cardon, Lon R; Walker, Mark; Hitman, Graham A; Palmer, Colin NA; Doney, Alex SF; Morris, Andrew D; Smith, George Davey; Hattersley, Andrew T; McCarthy, Mark I; (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (New York, NY), 316 (5826). pp. 889-894. ISSN 0036-8075 DOI: https://doi.org/10.1126/science.1141634
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Abstract
Obesity is a serious international health problem that increases the risk of several common diseases. The genetic factors predisposing to obesity are poorly understood. A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI). An additive association of the variant with BMI was replicated in 13 cohorts with 38,759 participants. The 16% of adults who are homozygous for the risk allele weighed about 3 kilograms more and had 1.67-fold increased odds of obesity when compared with those not inheriting a risk allele. This association was observed from age 7 years upward and reflects a specific increase in fat mass.
| Item Type | Article |
|---|---|
| Keywords | FUSED TOES FT, CANDIDATE, GAD2, ENPP1, Adipose Tissue, Adolescent, Adult, Aged, Alleles, Birth Weight, Body Mass Index, Case-Control Studies, Child, Cohort Studies, Diabetes Mellitus, Type 2, genetics, Female, Genetic Predisposition to Disease, Great Britain, Homozygote, Humans, Infant, Newborn, Male, Middle Aged, Obesity, genetics, Overweight, genetics, Polymorphism, Single Nucleotide |
| Faculty and Department | Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology |
| Research Centre | Centre for Global Non-Communicable Diseases (NCDs) |
| PubMed ID | 17434869 |
| ISI | 246369800038 |
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