Dynamic variation in the cellular origin of HIV type 1 during treatment of tuberculosis in dually infected subjects.
Toossi, Zahra;
Mayanja-Kizza, Harriet;
Lawn, Stephen D;
Hirsch, Christina S;
Lupo, L Davis;
Butera, Salvatore T;
(2007)
Dynamic variation in the cellular origin of HIV type 1 during treatment of tuberculosis in dually infected subjects.
AIDS research and human retroviruses, 23 (1).
pp. 93-100.
ISSN 0889-2229
DOI: https://doi.org/10.1089/aid.2006.0050
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HIV-1 replication remains elevated in dually infected HIV-1/TB subjects at completion of antituberculosis therapy. A viral immunocapture assay was used to examine the cellular origin of HIV-1 within plasma from HIV-1/TB subjects at time of diagnosis of pulmonary TB, at end of TB treatment, and 6 months after completion of treatment. Asymptomatic HIV-1-infected subjects without TB (HIV-1/C) served as controls. Both activated immature macrophage (CD36(+)) and CD4 T cell (CD26(+)) compartments contributed to viral load. Changes in the activation status of either cellular compartment paralleled their contribution to viral load. Levels of HIV-1 originating from activated (HLA-DR(+)) cells and from CD36(+) and CD26(+) mononuclear cells resolved to levels observed in HIV-1/C by the end of treatment. HIV-1 isolated by anti-CD3 immunocapture from HIV-1/TB patients remained significantly higher than from HIV-1/C patients at the end of TB treatment and at 12 months follow-up. Therefore, viral production by lymphocytes extends well beyond the completion of TB treatment.
