N'Guessan, Raphael; Corbel, Vincent; Akogbéto, Martin; Rowland, Mark; (2007) Reduced efficacy of insecticide-treated nets and indoor residual spraying for malaria control in pyrethroid resistance area, Benin. Emerging infectious diseases, 13 (2). pp. 199-206. ISSN 1080-6040 DOI: https://doi.org/10.3201/eid1302.060631
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Abstract
The pyrethroid knockdown resistance gene (kdr) has become widespread in Anopheles gambiae in West Africa. A trial to test the continuing efficacy of insecticide-treated nets (ITN) and indoor residual spraying (IRS) was undertaken in experimental huts at 2 sites in Benin, the first where kdr is present at high frequency (Ladji), the second-where An. gambiae is susceptible (Malanville). Holes were made in the nets to mimic worn nets. At Malanville, 96% of susceptible An. gambiae were inhibited from blood-feeding, whereas at Ladji feeding was uninhibited by ITNs. The mortality rate of An. gambiae in ITN huts was 98% in Malanville but only 30% at Ladji. The efficacy of IRS was equally compromised. Mosquitoes at Ladji had higher oxidase and esterase activity than in a laboratory-susceptible strain, but this fact did not seem to contribute to resistance. Pyrethroid resistance in An. gambiae appears to threaten the future of ITN and IRS in Benin.
Item Type | Article |
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Keywords | ANOPHELES-GAMBIAE, CULEX-QUINQUEFASCIATUS, IMPREGNATED BEDNETS, COTE-DIVOIRE, MOSQUITO-CONTROL, POPULATIONS, CARBAMATE, TANZANIA, MUTATION, VECTORS, Animals, Anopheles gambiae, drug effects, Bedding and Linens, Benin, epidemiology, Culex, drug effects, Humans, Insecticide Resistance, Insecticides, pharmacology, Malaria, prevention & control, Mosquito Control, methods, Nitriles, pharmacology, Pyrethrins, pharmacology |
Faculty and Department | Faculty of Infectious and Tropical Diseases > Dept of Disease Control |
Research Centre | Malaria Centre |
PubMed ID | 17479880 |
ISI | 244111000002 |
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Licence: Creative Commons: Attribution-Noncommercial-No Derivative Works 3.0
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