Harries, AD; Hargreaves, NJ; Gausi, F; Kwanjana, JH; Salaniponi, FM; (2001) High early death rate in tuberculosis patients in Malawi. The international journal of tuberculosis and lung disease, 5 (11). pp. 1000-1005. ISSN 1027-3719 https://researchonline.lshtm.ac.uk/id/eprint/8888
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https://researchonline.lshtm.ac.uk/id/eprint/8888
Abstract
SETTING: Thirty-eight district and mission hospitals in Malawi. OBJECTIVES: In patients registered with all types of tuberculosis (TB) in 1997 to determine 1) treatment outcomes, and 2) when in the course of anti-tuberculosis treatment TB deaths occurred. DESIGN: A retrospective study using information from TB registers, health centre registers, TB treatment cards and TB ward admission books. RESULTS: A total of 16,004 patients were registered with all types of TB, 6471 with smear-positive pulmonary tuberculosis (PTB), 5305 with smear-negative PTB and 4228 with extra-pulmonary tuberculosis (EPTB). Of patients with all types of TB, 3720 (23%) died: death rates were 22% in smear-positive PTB, 26% in smear-negative PTB and 22% in EPTB. Month of death was known in 3371 patients (91% of those who died) and day of death in 3326 patients (89% of those who died). In patients who died, 19% of deaths occurred by day 7 and 41% by the end of the first month of treatment. A higher proportion of early deaths occurred in patients with smear-negative PTB and EPTB and in relation to increasing age. CONCLUSIONS: There was a high overall death rate in TB patients registered in 1997, with 40% of deaths occurring in the first month of treatment. Strategies to combat this problem are needed.
Item Type | Article |
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Keywords | Adolescent, Adult, Aged, Antitubercular Agents, Female, Humans, Malawi, Male, Middle Aged, Retrospective Studies, Time Factors, Tuberculosis, Adolescent, Adult, Aged, Antitubercular Agents, administration & dosage, Female, Humans, Malawi, epidemiology, Male, Middle Aged, Retrospective Studies, Time Factors, Tuberculosis, diagnosis, drug therapy, mortality |
Faculty and Department | Faculty of Infectious and Tropical Diseases > Dept of Clinical Research |
PubMed ID | 11716335 |
ISI | 172014700004 |