New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

Momoko Horikoshi ; Hanieh Yaghootkar ; Dennis O Mook-Kanamori ; Ulla Sovio ; H Rob Taal ; Branwen J Hennig ; Jonathan P Bradfield ; Beate St Pourcain ; David M Evans ; Pimphen Charoen ; +140 more... Marika Kaakinen ; Diana L Cousminer ; Terho Lehtimäki ; Eskil Kreiner-Møller ; Nicole M Warrington ; Mariona Bustamante ; Bjarke Feenstra ; Diane J Berry ; Elisabeth Thiering ; Thiemo Pfab ; Sheila J Barton ; Beverley M Shields ; Marjan Kerkhof ; Elisabeth M van Leeuwen ; Anthony J Fulford ; Zoltán Kutalik ; Jing Hua Zhao ; Marcel den Hoed ; Anubha Mahajan ; Virpi Lindi ; Liang-Kee Goh ; Jouke-Jan Hottenga ; Ying Wu ; Olli T Raitakari ; Marie N Harder ; Aline Meirhaeghe ; Ioanna Ntalla ; Rany M Salem ; Karen A Jameson ; Kaixin Zhou ; Dorota M Monies ; Vasiliki Lagou ; Mirna Kirin ; Jani Heikkinen ; Linda S Adair ; Fowzan S Alkuraya ; Ali Al-Odaib ; Philippe Amouyel ; Ehm Astrid Andersson ; Amanda J Bennett ; Alexandra IF Blakemore ; Jessica L Buxton ; Jean Dallongeville ; Shikta Das ; Eco JC de Geus ; Xavier Estivill ; Claudia Flexeder ; Philippe Froguel ; Frank Geller ; Keith M Godfrey ; Frédéric Gottrand ; Christopher J Groves ; Torben Hansen ; Joel N Hirschhorn ; Albert Hofman ; Mads V Hollegaard ; David M Hougaard ; Elina Hyppönen ; Hazel M Inskip ; Aaron Isaacs ; Torben Jørgensen ; Christina Kanaka-Gantenbein ; John P Kemp ; Wieland Kiess ; Tuomas O Kilpeläinen ; Norman Klopp ; Bridget A Knight ; Christopher W Kuzawa ; George McMahon ; John P Newnham ; Harri Niinikoski ; Ben A Oostra ; Louise Pedersen ; Dirkje S Postma ; Susan M Ring ; Fernando Rivadeneira ; Neil R Robertson ; Sylvain Sebert ; Olli Simell ; Torsten Slowinski ; Carla MT Tiesler ; Anke Tönjes ; Allan Vaag ; Jorma S Viikari ; Jacqueline M Vink ; Nadja Hawwa Vissing ; Nicholas J Wareham ; Gonneke Willemsen ; Daniel R Witte ; Haitao Zhang ; Jianhua Zhao ; Meta-Analyses of Glucose- and Insulin-related traits Consortium ; James F Wilson ; Michael Stumvoll ; Andrew M Prentice ORCID logo ; Brian F Meyer ; Ewan R Pearson ; Colin AG Boreham ; Cyrus Cooper ; Matthew W Gillman ; George V Dedoussis ; Luis A Moreno ; Oluf Pedersen ; Maiju Saarinen ; Karen L Mohlke ; Dorret I Boomsma ; Seang-Mei Saw ; Timo A Lakka ; Antje Körner ; Ruth JF Loos ; Ken K Ong ; Peter Vollenweider ; Cornelia M van Duijn ; Gerard H Koppelman ; Andrew T Hattersley ; John W Holloway ; Berthold Hocher ; Joachim Heinrich ; Chris Power ; Mads Melbye ; Mònica Guxens ; Craig E Pennell ; Klaus Bønnelykke ; Hans Bisgaard ; Johan G Eriksson ; Elisabeth Widén ; Hakon Hakonarson ; André G Uitterlinden ; Anneli Pouta ; Debbie A Lawlor ; George Davey Smith ; Timothy M Frayling ; Mark I McCarthy ; Struan FA Grant ; Vincent WV Jaddoe ; Marjo-Riitta Jarvelin ; Nicholas J Timpson ; Inga Prokopenko ; Rachel M Freathy ; Early Growth Genetics (EGG) Consortium ; (2013) New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nature genetics, 45 (1). pp. 76-82. ISSN 1061-4036 DOI: 10.1038/ng.2477
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Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
Item Type Article
ISI 312838800016
Date Deposited 18 May 2013 10:59

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