Plasma viral loads during early HIV-1 infection are similar in subtype C- and non-subtype C-infected African seroconverters.

Mary S Campbell ; Erin M Kahle ; Connie Celum ; Jairam R Lingappa ; Saidi Kapiga

; Andrew Mujugira ; Nelly R Mugo ; Kenneth H Fife ; James I Mullins ; Jared M Baeten ; +1 more... Partners in Prevention HSV/HIV Transmission Study Team ; (2013) Plasma viral loads during early HIV-1 infection are similar in subtype C- and non-subtype C-infected African seroconverters. The Journal of infectious diseases, 207 (7). pp. 1166-1170. ISSN 0022-1899 DOI: 10.1093/infdis/jit015

Copy

Recent data suggest that infection with human immunodeficiency virus type 1 (HIV-1) subtype C results in prolonged high-level viremia (>5 log10 copies/mL) during early infection. We examined the relationship between HIV-1 subtype and plasma viremia among 153 African seroconverters. Mean setpoint viral loads were similar for C and non-C subtypes: 4.36 vs 4.42 log10 copies/mL (P = .61). The proportion of subtype C-infected participants with viral loads >5 log10 copies/mL was not greater than the proportion for those with non-C infection. Our data do not support the hypothesis that higher early viral load accounts for the rapid spread of HIV-1 subtype C in southern Africa.

Item Type	Article
Keywords	Adult, Africa, Eastern, African Continental Ancestry Group, Disease Transmission, Infectious, prevention & control, Female, HIV Infections, blood, prevention & control, virology, HIV Seropositivity, virology, HIV-1, classification, genetics, pathogenicity, Humans, Male, Middle Aged, Prospective Studies, RNA, Viral, blood, Sensitivity and Specificity, South Africa, Time Factors, Viral Load, Viremia, virology, env Gene Products, Human Immunodeficiency Virus, genetics, gag Gene Products, Human Immunodeficiency Virus, genetics
ISI	315643100018
Date Deposited	13 May 2013 19:08