A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk.
Peter
Broderick
;
Luis
Carvajal-Carmona
;
Alan M
Pittman
;
Emily
Webb
;
Kimberley
Howarth
;
Andrew
Rowan
;
Steven
Lubbe
;
Sarah
Spain
;
Kate
Sullivan
;
Sarah
Fielding
;
+22 more...
Emma
Jaeger
;
Jayaram
Vijayakrishnan
;
Zoe
Kemp
;
Maggie
Gorman
;
Ian
Chandler
;
Elli
Papaemmanuil
;
Steven
Penegar
;
Wendy
Wood
;
Gabrielle
Sellick
;
Mobshra
Qureshi
;
Ana
Teixeira
;
Enric
Domingo
;
Ella
Barclay
;
Lynn
Martin
;
Oliver
Sieber
;
CORGI Consortium
;
David
Kerr
;
Richard
Gray
;
Julian
Peto
;
Jean-Baptiste
Cazier
;
Ian
Tomlinson
;
Richard S
Houlston
;
(2007)
A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk.
Nature genetics, 39 (11).
pp. 1315-1317.
ISSN 1061-4036
DOI: 10.1038/ng.2007.18
;
Kimberley
Howarth
;
Andrew
Rowan
;
Steven
Lubbe
;
Sarah
Spain
;
Kate
Sullivan
;
Sarah
Fielding
;
+22 more...
Emma
Jaeger
;
Jayaram
Vijayakrishnan
;
Zoe
Kemp
;
Maggie
Gorman
;
Ian
Chandler
;
Elli
Papaemmanuil
;
Steven
Penegar
;
Wendy
Wood
;
Gabrielle
Sellick
;
Mobshra
Qureshi
;
Ana
Teixeira
;
Enric
Domingo
;
Ella
Barclay
;
Lynn
Martin
;
Oliver
Sieber
;
CORGI Consortium
;
David
Kerr
;
Richard
Gray
;
Julian
Peto
;
Jean-Baptiste
Cazier
;
Ian
Tomlinson
;
Richard S
Houlston
;
(2007)
A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk.
Nature genetics, 39 (11).
pp. 1315-1317.
ISSN 1061-4036
DOI: 10.1038/ng.2007.18
To identify risk variants for colorectal cancer (CRC), we conducted a genome-wide association study, genotyping 550,163 tag SNPs in 940 individuals with familial colorectal tumor (627 CRC, 313 advanced adenomas) and 965 controls. We evaluated selected SNPs in three replication sample sets (7,473 cases, 5,984 controls) and identified three SNPs in SMAD7 (involved in TGF-beta and Wnt signaling) associated with CRC. Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (P(trend) = 1.0 x 10(-12)).
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