Safety of a trivalent meningococcal ACW135 vaccine among young children in Ethiopia.
Aseffa, Abraham;
Bedru, Ahmed;
Yamuah, Lawrence;
Arga, Demis;
Worku, Alemayehu;
Chandramohan, Daniel;
Nelson, Christopher B;
Engers, Howard D;
(2007)
Safety of a trivalent meningococcal ACW135 vaccine among young children in Ethiopia.
Vaccine, 25 Sup (SUPPL.).
A79-A82.
ISSN 0264-410X
DOI: https://doi.org/10.1016/j.vaccine.2007.04.046
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A phase II open and parallel reactogenicity, immunogenicity and safety trivalent meningitis vaccine (Mencevax) trial was conducted on 413 volunteer 2-29-year-old rural residents in Ethiopia in November/December 2005. Adverse events (AE) were monitored at 1h, 1, 2, 3, 7 and 28 days after vaccination. No serious AE occurred except for burn injury (one) and severe malaria (one) after day 28. Irritability (45/411), loss of appetite (27/411), pain at injection site (26/412), dizziness (18/409), crying (14/411), insomnia, headache and diarrhoea (13/411) were the most frequent AEs. Overall, the vaccine is safe in the age groups studied.
