Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.
Jaeger, Emma; Webb, Emily
; Howarth, Kimberley; Carvajal-Carmona, Luis; Rowan, Andrew; Broderick, Peter; Walther, Axel; Spain, Sarah; Pittman, Alan; Kemp, Zoe; +25 more...Sullivan, Kate; Heinimann, Karl; Lubbe, Steven; Domingo, Enric; Barclay, Ella; Martin, Lynn; Gorman, Maggie; Chandler, Ian; Vijayakrishnan, Jayaram; Wood, Wendy; Papaemmanuil, Elli; Penegar, Steven; Qureshi, Mobshra; CORGI Consortium; Farrington, Susan; Tenesa, Albert; Cazier, Jean-Baptiste; Kerr, David; Gray, Richard; Peto, Julian; Dunlop, Malcolm; Campbell, Harry; Thomas, Huw; Houlston, Richard; and Tomlinson, Ian
(2008)
Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.
Nature genetics, 40 (1).
pp. 26-28.
ISSN 1061-4036
DOI: 10.1038/ng.2007.41
; Howarth, Kimberley; Carvajal-Carmona, Luis; Rowan, Andrew; Broderick, Peter; Walther, Axel; Spain, Sarah; Pittman, Alan; Kemp, Zoe; +25 more...Sullivan, Kate; Heinimann, Karl; Lubbe, Steven; Domingo, Enric; Barclay, Ella; Martin, Lynn; Gorman, Maggie; Chandler, Ian; Vijayakrishnan, Jayaram; Wood, Wendy; Papaemmanuil, Elli; Penegar, Steven; Qureshi, Mobshra; CORGI Consortium; Farrington, Susan; Tenesa, Albert; Cazier, Jean-Baptiste; Kerr, David; Gray, Richard; Peto, Julian; Dunlop, Malcolm; Campbell, Harry; Thomas, Huw; Houlston, Richard; and Tomlinson, Ian
(2008)
Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.
Nature genetics, 40 (1).
pp. 26-28.
ISSN 1061-4036
DOI: 10.1038/ng.2007.41
We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 x 10(-14)).
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