Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.
Emma
Jaeger
;
Emily
Webb
;
Kimberley
Howarth
;
Luis
Carvajal-Carmona
;
Andrew
Rowan
;
Peter
Broderick
;
Axel
Walther
;
Sarah
Spain
;
Alan
Pittman
;
Zoe
Kemp
;
+25 more...
Kate
Sullivan
;
Karl
Heinimann
;
Steven
Lubbe
;
Enric
Domingo
;
Ella
Barclay
;
Lynn
Martin
;
Maggie
Gorman
;
Ian
Chandler
;
Jayaram
Vijayakrishnan
;
Wendy
Wood
;
Elli
Papaemmanuil
;
Steven
Penegar
;
Mobshra
Qureshi
;
CORGI Consortium
;
Susan
Farrington
;
Albert
Tenesa
;
Jean-Baptiste
Cazier
;
David
Kerr
;
Richard
Gray
;
Julian
Peto
;
Malcolm
Dunlop
;
Harry
Campbell
;
Huw
Thomas
;
Richard
Houlston
;
Ian
Tomlinson
;
(2008)
Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.
Nature genetics, 40 (1).
pp. 26-28.
ISSN 1061-4036
DOI: 10.1038/ng.2007.41
;
Kimberley
Howarth
;
Luis
Carvajal-Carmona
;
Andrew
Rowan
;
Peter
Broderick
;
Axel
Walther
;
Sarah
Spain
;
Alan
Pittman
;
Zoe
Kemp
;
+25 more...
Kate
Sullivan
;
Karl
Heinimann
;
Steven
Lubbe
;
Enric
Domingo
;
Ella
Barclay
;
Lynn
Martin
;
Maggie
Gorman
;
Ian
Chandler
;
Jayaram
Vijayakrishnan
;
Wendy
Wood
;
Elli
Papaemmanuil
;
Steven
Penegar
;
Mobshra
Qureshi
;
CORGI Consortium
;
Susan
Farrington
;
Albert
Tenesa
;
Jean-Baptiste
Cazier
;
David
Kerr
;
Richard
Gray
;
Julian
Peto
;
Malcolm
Dunlop
;
Harry
Campbell
;
Huw
Thomas
;
Richard
Houlston
;
Ian
Tomlinson
;
(2008)
Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.
Nature genetics, 40 (1).
pp. 26-28.
ISSN 1061-4036
DOI: 10.1038/ng.2007.41
We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 x 10(-14)).
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