Do patients who are infected with drug-resistant HIV have a different CD4 cell decline after seroconversion? An exploratory analysis in the UK Register of HIV Seroconverters.

Krishnan Bhaskaran ORCID logo ; Deenan Pillay ; A Sarah Walker ; Martin Fisher ; David Hawkins ; Richard Gilson ; Ken McLean ; Kholoud Porter ; UK Register of HIV Seroconverters ; (2004) Do patients who are infected with drug-resistant HIV have a different CD4 cell decline after seroconversion? An exploratory analysis in the UK Register of HIV Seroconverters. AIDS (London, England), 18 (10). pp. 1471-1473. ISSN 0269-9370 DOI: 10.1097/01.aids.0000131341.45795.33
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Using data from the UK Register of HIV Sero-converters, we compared the rate of CD4 cell decline in antiretroviral-naive individuals with and without evidence of transmitted drug resistance (TDR). Although there was a suggestion that CD4 cell decline in the first year after seroconversion was faster in those with TDR,there was no evidence of a difference in the rate of decline thereafter. The virological and host determinants of this possible phenomenon are worth further exploration.

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