Do patients who are infected with drug-resistant HIV have a different CD4 cell decline after seroconversion? An exploratory analysis in the UK Register of HIV Seroconverters.

Bhaskaran, Krishnan; Pillay, Deenan; Walker, A Sarah; Fisher, Martin; Hawkins, David; Gilson, Richard; McLean, Ken; Porter, Kholoud; UK Register of HIV Seroconverters; (2004) Do patients who are infected with drug-resistant HIV have a different CD4 cell decline after seroconversion? An exploratory analysis in the UK Register of HIV Seroconverters. AIDS (London, England), 18 (10). pp. 1471-1473. ISSN 0269-9370 DOI: https://doi.org/10.1097/01.aids.0000131341.45795.33

Abstract

Using data from the UK Register of HIV Sero-converters, we compared the rate of CD4 cell decline in antiretroviral-naive individuals with and without evidence of transmitted drug resistance (TDR). Although there was a suggestion that CD4 cell decline in the first year after seroconversion was faster in those with TDR,there was no evidence of a difference in the rate of decline thereafter. The virological and host determinants of this possible phenomenon are worth further exploration.

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Item Type	Article
Keywords	Adult, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes/ immunology/virology, Cohort Studies, Drug Resistance, Viral/ immunology, Female, HIV Infections/ drug therapy, HIV Seropositivity/immunology, Humans, Lymphopenia/virology, Male, Adult, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes, immunology, virology, Cohort Studies, Drug Resistance, Viral, immunology, Female, HIV Infections, drug therapy, HIV Seropositivity, immunology, Humans, Lymphopenia, virology, Male
Faculty and Department	Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
PubMed ID	15199326
ISI	222641500016

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Do patients who are infected with drug-resistant HIV have a different CD4 cell decline after seroconversion? An exploratory analysis in the UK Register of HIV Seroconverters.

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