Copy to clipboardCopy Tsotinis, Andrew; Papanastasiou, Ioannis; B. Foscolos, George; Ol�, Judit; Ov�i, Judit; Radhika Prathalingam, S; M. Kelly, John; (2008) Conformationally Constrained Adamantaneoxazolines of Pharmacological Interest. Heterocycles, 75 (8). p. 2043. ISSN 0385-5414 DOI: https://doi.org/10.3987/com-08-11377
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Copy to clipboardCopyhttps://doi.org/10.3987/com-08-11377
New conformationally constrained adamantane 2-oxazoline building blocks 1-4 were synthesized and their antimicrotubule and antitrypanosomal potency was investigated. Although most of the new compounds affect tubulin polymerization, this does not make a major contribution to trypanocidal activity. © 2008 The Japan Institute of Heterocyclic Chemistry.
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