Conformationally Constrained Adamantaneoxazolines of Pharmacological Interest
Andrew
Tsotinis
;
Ioannis
Papanastasiou
;
George
B. Foscolos
;
Judit
Ol�
;
Judit
Ov�i
;
S
Radhika Prathalingam
;
John
M. Kelly
;
(2008)
Conformationally Constrained Adamantaneoxazolines of Pharmacological Interest.
Heterocycles, 75 (8).
p. 2043.
ISSN 0385-5414
DOI: 10.3987/com-08-11377
New conformationally constrained adamantane 2-oxazoline building blocks 1-4 were synthesized and their antimicrotubule and antitrypanosomal potency was investigated. Although most of the new compounds affect tubulin polymerization, this does not make a major contribution to trypanocidal activity. © 2008 The Japan Institute of Heterocyclic Chemistry.
| Item Type | Article |
|---|---|
| ISI | 259131300016 |
| Date Deposited | 17 Oct 2011 16:09 |