Population differences in immune responses to Bacille Calmette-Guérin vaccination in infancy.

Lalor, Maeve K; Ben-Smith, Anne; Gorak-Stolinska, Patricia; Weir, Rosemary E; Floyd, Sian; Blitz, Rose; Mvula, Hazzie; Newport, Melanie J; Branson, Keith; McGrath, Nuala; +3 more... Crampin, Amelia C; Fine, Paul EM; Dockrell, Hazel M; (2009) Population differences in immune responses to Bacille Calmette-Guérin vaccination in infancy. The Journal of infectious diseases, 199 (6). pp. 795-800. ISSN 0022-1899 DOI: https://doi.org/10.1086/597069

Abstract

Bacille Calmette-Guérin (BCG) vaccination induces a marked increase in the interferon (IFN)-gamma response to Mycobacterium tuberculosis purified protein derivative (Mtb PPD) in UK adolescents, but not in Malawian adolescents. We hypothesized that Mtb PPD-induced IFN-gamma after BCG vaccination would be similar in infants from these 2 countries. Infants were vaccinated with BCG during the first 3-13 weeks of life. Three months after BCG vaccination, 51 (100%) of 51 UK infants had an IFN-gamma response to Mtb PPD, compared to 41 (53%) of 78 of Malawian infants, in whom responses varied according to their season of birth. We conclude that population differences in immune responses after BCG vaccination are observed among infants, as well as among young adults.

Additional Information

Item Type	Article
Faculty and Department	Faculty of Infectious and Tropical Diseases > Department of Infection Biology Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
Research Centre	Centre for Maternal, Reproductive and Child Health (MARCH) TB Centre Vaccine Centre Population Studies Group Tropical Epidemiology Group
PubMed ID	19434928
ISI	263677900005
Related URLs	OA Location