Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2.
;
Julian
Peto
;
Michael R
Stratton
;
Nazneen
Rahman
;
Kevin
Jacobs
;
Ross
Prentice
;
Garnet L
Anderson
;
Aleksandar
Rajkovic
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J David
Curb
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Regina G
Ziegler
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Christine D
Berg
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Saundra S
Buys
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Catherine A
McCarty
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Heather Spencer
Feigelson
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Eugenia E
Calle
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Michael J
Thun
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W Ryan
Diver
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Stig
Bojesen
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Børge G
Nordestgaard
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Henrik
Flyger
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Thilo
Dörk
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Peter
Schürmann
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Peter
Hillemanns
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Johann H
Karstens
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Natalia V
Bogdanova
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Natalia N
Antonenkova
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Iosif V
Zalutsky
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Marina
Bermisheva
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Sardana
Fedorova
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Elza
Khusnutdinova
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SEARCH
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Daehee
Kang
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Keun-Young
Yoo
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Dong Young
Noh
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Sei-Hyun
Ahn
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Peter
Devilee
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Christi J
van Asperen
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RAEM
Tollenaar
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Caroline
Seynaeve
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Montserrat
Garcia-Closas
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Jolanta
Lissowska
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Louise
Brinton
;
Beata
Peplonska
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Heli
Nevanlinna
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Tuomas
Heikkinen
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Kristiina
Aittomäki
;
Carl
Blomqvist
;
John L
Hopper
;
Melissa C
Southey
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Letitia
Smith
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Amanda B
Spurdle
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Marjanka K
Schmidt
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Annegien
Broeks
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Richard R
van Hien
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Sten
Cornelissen
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Roger L
Milne
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Gloria
Ribas
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Anna
González-Neira
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Javier
Benitez
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Rita K
Schmutzler
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Barbara
Burwinkel
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Claus R
Bartram
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Alfons
Meindl
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Hiltrud
Brauch
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Christina
Justenhoven
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Ute
Hamann
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GENICA Consortium
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Jenny
Chang-Claude
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Rebecca
Hein
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Shan
Wang-Gohrke
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Annika
Lindblom
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Sara
Margolin
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Arto
Mannermaa
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Veli-Matti
Kosma
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Vesa
Kataja
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Janet E
Olson
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Xianshu
Wang
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Zachary
Fredericksen
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Graham G
Giles
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Gianluca
Severi
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Laura
Baglietto
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Dallas R
English
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Susan E
Hankinson
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David G
Cox
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Peter
Kraft
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Lars J
Vatten
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Kristian
Hveem
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Merethe
Kumle
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Alice
Sigurdson
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Michele
Doody
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Parveen
Bhatti
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Bruce H
Alexander
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Maartje J
Hooning
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Ans MW
van den Ouweland
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Rogier A
Oldenburg
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Mieke
Schutte
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Per
Hall
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Kamila
Czene
;
Jianjun
Liu
;
Yuqing
Li
;
Angela
Cox
;
Graeme
Elliott
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Ian
Brock
;
Malcolm WR
Reed
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Chen-Yang
Shen
;
Jyh-Cherng
Yu
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Giu-Cheng
Hsu
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Shou-Tung
Chen
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Hoda
Anton-Culver
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Argyrios
Ziogas
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Irene L
Andrulis
;
Julia A
Knight
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kConFab
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Australian Ovarian Cancer Study Group
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Jonathan
Beesley
;
Ellen L
Goode
;
Fergus
Couch
;
Georgia
Chenevix-Trench
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Robert N
Hoover
;
Bruce AJ
Ponder
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David J
Hunter
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Paul DP
Pharoah
;
Alison M
Dunning
;
Stephen J
Chanock
;
Douglas F
Easton
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(2009)
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2.
Nature genetics, 41 (5).
pp. 585-590.
ISSN 1061-4036
DOI: 10.1038/ng.354
Genome-wide association studies (GWAS) have identified seven breast cancer susceptibility loci, but these explain only a small fraction of the familial risk of the disease. Five of these loci were identified through a two-stage GWAS involving 390 familial cases and 364 controls in the first stage, and 3,990 cases and 3,916 controls in the second stage. To identify additional loci, we tested over 800 promising associations from this GWAS in a further two stages involving 37,012 cases and 40,069 controls from 33 studies in the CGEMS collaboration and Breast Cancer Association Consortium. We found strong evidence for additional susceptibility loci on 3p (rs4973768: per-allele OR = 1.11, 95% CI = 1.08-1.13, P = 4.1 x 10(-23)) and 17q (rs6504950: per-allele OR = 0.95, 95% CI = 0.92-0.97, P = 1.4 x 10(-8)). Potential causative genes include SLC4A7 and NEK10 on 3p and COX11 on 17q.