Evaluation of a PCR-based universal heteroduplex generator assay as a tool for rapid detection of multidrug-resistant Mycobacterium tuberculosis in Peru.
Mayta, Holger;
Gilman, Robert H;
Arenas, Fanny;
Valencia, Teresa;
Caviedes, Luz;
Montenegro, Sonia H;
Ticona, Eduardo;
Ortiz, Jaime;
Chumpitaz, Rosa;
Evans, Carlton A;
+2 more...Williams, Diana L;
Tuberculosis Working Group in Perú;
(2003)
Evaluation of a PCR-based universal heteroduplex generator assay as a tool for rapid detection of multidrug-resistant Mycobacterium tuberculosis in Peru.
Journal of clinical microbiology, 41 (12).
pp. 5774-5777.
ISSN 0095-1137
DOI: https://doi.org/10.1128/JCM.41.12.5774-5777.2003
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Multidrug-resistant tuberculosis is an increasing health problem worldwide, especially in developing countries. The PCR-UHG-Rif assay, which detects mutations within the rpoB gene associated with rifampin resistance, was evaluated for its ability and reliability to detect and identify drug-resistant Mycobacterium tuberculosis in a developing country where tuberculosis is highly endemic.
