Improved diagnosis of pleural tuberculosis using the microscopic- observation drug-susceptibility technique.

Tovar, Marco; Siedner, Mark J; Gilman, Robert H; Santillan, Carlos; Caviedes, Luz; Valencia, Teresa; Jave, Oswaldo; Escombe, A Rod; Moore, David AJ

; and Evans, Carlton A (2008) Improved diagnosis of pleural tuberculosis using the microscopic- observation drug-susceptibility technique. Clinical infectious diseases, 46 (6). pp. 909-912. ISSN 1058-4838 DOI: 10.1086/527447

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Tests for pleural tuberculosis are insensitive and expensive. We compared nonproprietary microscopic-observation drug-susceptibility (MODS) culture with Löwenstein-Jensen culture for evaluation of pleural specimens. MODS culture was associated with greatly increased diagnostic sensitivity and shorter time to diagnosis, compared with Löwenstein-Jensen culture (sensitivity of culture of biopsy specimens, 81% vs.51%; time to diagnosis, 11 days vs. 24 days; P < .001). The MODS technique is inexpensive, allows drug-susceptibility testing, and is a considerably improved diagnostic method for pleural tuberculosis.

Item Type	Article
Keywords	Adolescent, Adult, Aged, Aged, 80 and over, Antitubercular Agents/pharmacology, Culture Media, Female, Humans, Male, Microbial Sensitivity Tests/methods, Microscopy/methods, Middle Aged, Mycobacterium tuberculosis/drug effects/isolation & purification, Sensitivity and Specificity, Time Factors, Tuberculosis, Pleural/*diagnosis/microbiology
ISI	253453800022
Date Deposited	17 Oct 2011 15:17