Association of health knowledge with adoption of heart healthy behaviours: a cross-cohort analysis using data from the PURE Study.

Shiva Raj Mishra ORCID logo ; Richard Lindley ORCID logo ; Angela Webster ; Patricio Lopez-Jaramillo ORCID logo ; Rosnah Ismail ; Jayachitra Krishnaswamy Gajendran ; Indu Mohan ; Rekha M Ravindran ; Manmeet Kaur ; Christina E Lundberg ; +23 more... Karen Yeates ; Khalid F Alhabib ORCID logo ; Roya Kelishadi ; Katarzyna Zatonska ; Homer U Co ; Scott A Lear ORCID logo ; Karen Suarez ; Iolanthé M Kruger ; Pamela Serón ; Maria Luz Diaz ; Yilin Huang ; Zhiguang Liu ; Yingxuan Zhu ; Alvaro Avezum ; Afzalhussein Yusufali ; Rita Yusuf ; Jephat Chifamba ; Ahmet Temizhan ; Romaina Iqbal ; Sumathy Rangarajan ORCID logo ; Martin McKee ORCID logo ; Salim Yusuf ; Clara K Chow ; (2025) Association of health knowledge with adoption of heart healthy behaviours: a cross-cohort analysis using data from the PURE Study. European journal of preventive cardiology. zwaf428. ISSN 2047-4873 DOI: 10.1093/eurjpc/zwaf428 (In Press)
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Aims: This study aims to assess aspects of health knowledge: i) awareness of health effect of tobacco smoking and ii) awareness of preventive actions for heart disease and stroke, and their relationships with adoption of heart healthy behaviours (smoking cessation and utilisation of antihypertensive treatment).

Methods: In this multi-cohort study, we recruited adults aged 35 to 70 years from 21 countries. Data on health effects of tobacco smoking (10 questions) and health actions to prevent heart disease or stroke (11 questions) were collected at baseline. Logistic regression analyses were used to examine the relationship with the outcomes of smoking cessation and use of antihypertensive treatment adjusting for adjusting for possible confounders.

Results: Of the 12,962 included in the descriptive analysis, 50.0% were female, 42.9% had no or primary education, and 53.3 % were residing in low or lower middle-income country. Among current and former smokers, having knowledge of health effect of tobacco smoking on heart disease [Adjusted Odds Ratio (aOR): 1.70, 95% CI: 1.19, 2.43)], stroke (1.41, 1.08,1.86), and on heart disease in non-smokers exposed to others smoking (1.40, 1.06,1.86) were significantly and positively associated with smoking cessation compared to those who were not aware of health effects. Knowledge of the importance of reducing dietary salt aOR 1.62 (1.23,2.13), dietary fat aOR 1.56 (1.17,2.08) and exercising more aOR 1.48 (1.22,1.80) to prevent heart disease or stroke were positively associated with taking anti-hypertensive medication compared to those who were not aware of preventative actions.

Conclusion: This study reinforces that better health knowledge shapes adoption of heart healthy behaviours such as smoking cessation and taking anti-hypertensive treatment even after accounting for baseline education and wealth.

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