Polygenic prediction of body mass index and obesity through the life course and across ancestries.
Smit, Roelof AJ; Wade, Kaitlin H; Hui, Qin; Arias, Joshua D
; Yin, Xianyong; Christiansen, Malene R; Yengo, Loic; Preuss, Michael H; Nakabuye, Mariam; Rocheleau, Ghislain; +624 more...Graham, Sarah E; Buchanan, Victoria L; Chittoor, Geetha; Graff, Marielisa; Guindo-Martínez, Marta; Lu, Yingchang; Marouli, Eirini; Sakaue, Saori; Spracklen, Cassandra N; Vedantam, Sailaja; Wilson, Emma P; Chen, Shyh-Huei; Ferreira, Teresa; Ji, Yingjie; Karaderi, Tugce; Lüll, Kreete; Machado, Moara; Malden, Deborah E; Medina-Gomez, Carolina; Moore, Amy; Rüeger, Sina; Akiyama, Masato; Allison, Matthew A; Alvarez, Marcus; Andersen, Mette K; Appadurai, Vivek; Arbeeva, Liubov; Bartell, Eric; Bhaskar, Seema; Bielak, Lawrence F; Bis, Joshua C; Bollepalli, Sailalitha; Bork-Jensen, Jette; Bradfield, Jonathan P; Bradford, Yuki; Brandl, Caroline; Braund, Peter S; Brody, Jennifer A; Broeckel, Ulrich; Burgdorf, Kristoffer S; Cade, Brian E; Cai, Qiuyin; Camarda, Silvia; Campbell, Archie; Cañadas-Garre, Marisa; Chai, Jin-Fang; Chesi, Alessandra; Choi, Seung Hoan; Christofidou, Paraskevi; Couture, Christian; Cuellar-Partida, Gabriel; Danning, Rebecca; Degenhardt, Frauke; Delgado, Graciela E; Delitala, Alessandro; Demirkan, Ayşe; Deng, Xuan; Dietl, Alexander; Dimitriou, Maria; Dimitrov, Latchezar; Dorajoo, Rajkumar; Eichelmann, Fabian; Eliasen, Anders U; Engmann, Jorgen E; Erdos, Michael R; Fairhurst-Hunter, Zammy; Farmaki, Aliki-Eleni; Faul, Jessica D; Fernandez-Lopez, Juan-Carlos; Forer, Lukas; Frank, Mirjam; Freitag-Wolf, Sandra; Fritsche, Lars G; Fuchsberger, Christian; Galesloot, Tessel E; Gao, Yan; Geller, Frank; Giannakopoulou, Olga; Giulianini, Franco; Gjesing, Anette P; Goel, Anuj; Gordon, Scott D; Gorski, Mathias; Grove, Jakob; Guo, Xiuqing; Gustafsson, Stefan; Haessler, Jeffrey; Hansen, Thomas F; Havulinna, Aki S; Haworth, Simon J; Heard-Costa, Nancy; Hemerich, Daiane; Highland, Heather M; Hindy, George; Ho, Yuk-Lam; Hofer, Edith; Holliday, Elizabeth; Horn, Katrin; Hornsby, Whitney E; Hottenga, Jouke-Jan; Huang, Hongyan; Huang, Jie; Huerta-Chagoya, Alicia; Huo, Shaofeng; Hwang, Mi Yeong; Hwu, Chii-Min; Iha, Hiroyuki; Ikeda, Daisuke D; Isono, Masato; Jackson, Anne U; Jansen, Iris E; Jiang, Yunxuan; Johansson, Ingegerd; Jonsson, Anna; Jørgensen, Torben; Kalafati, Ioanna P; Kanai, Masahiro; Kanoni, Stavroula; Kårhus, Line L; Kasturiratne, Anuradhani; Katsuya, Tomohiro; Kawaguchi, Takahisa; Kember, Rachel L; Kentistou, Katherine A; Kim, Daeeun; Kim, Han-Na; Kim, Young Jin; Kleber, Marcus E; Knol, Maria J; Kurbasic, Azra; Lauzon, Marie; Le, Phuong; Lea, Rodney; Lee, Jong-Young; Lee, Wen-Jane; Leonard, Hampton L; Li, Hengtong; Li, Shengchao A; Li, Xiaohui; Li, Xiaoyin; Liang, Jingjing; Lin, Honghuang; Lin, Kuang; Liu, Jun; Liu, Xueping; Lo, Ken Sin; Long, Jirong; Lores-Motta, Laura; Luan, Jian'an; Lyssenko, Valeriya; Lyytikäinen, Leo-Pekka; Mahajan, Anubha; Malik, Md Zubbair; Mamakou, Vasiliki; Mangino, Massimo; Manichaikul, Ani; Marten, Jonathan; Mattheisen, Manuel; McDaid, Aaron F; Mei, Quanshun; Meiselbach, Heike; Melendez, Tori L; Milaneschi, Yuri; Miller, Jason E; Millwood, Iona Y; Mishra, Pashupati P; Mitchell, Ruth E; Møllehave, Line T; Mononen, Nina; Mucha, Sören; Munz, Matthias; Mykkänen, Juha; Nakatochi, Masahiro; Nardone, Giuseppe Giovanni; Nelson, Christopher P; Nethander, Maria; Nho, Chu Won; Nielsen, Aneta A; Nolte, Ilja M; Nongmaithem, Suraj S; Noordam, Raymond; Ntalla, Ioanna; Nutile, Teresa; Pandit, Anita; Pauper, Marc; Petersen, Eva RB; Petersen, Liselotte V; Piluso, Francesco; Polašek, Ozren; Poveda, Alaitz; Pyarajan, Saiju; Raffield, Laura M; Rakugi, Hiromi; Ramirez, Julia; Rasheed, Asif; Raven, Dennis; Rayner, Nigel W; Riveros, Carlos; Rohde, Rebecca; Ruggiero, Daniela; Ruotsalainen, Sanni E; Ryan, Kathleen A; Sabater-Lleal, Maria; Santin, Aurora; Saxena, Richa; Scholz, Markus; Shen, Botong; Shi, Jingchunzi; Shin, Jae Hun; Sidore, Carlo; Sidorenko, Julia; Sim, Xueling; Slieker, Roderick C; Smith, Albert V; Smith, Jennifer A; Smyth, Laura J; Southam, Lorraine; Steinthorsdottir, Valgerdur; Sun, Liang; Takeuchi, Fumihiko; Taylor, Kent D; Tayo, Bamidele O; Tcheandjieu, Catherine; Terzikhan, Natalie; Tesolin, Paola; Teumer, Alexander; Theusch, Elizabeth; Thompson, Deborah J; Thorleifsson, Gudmar; Timmers, Paul RHJ; Trompet, Stella; Turman, Constance; Vaccargiu, Simona; van der Laan, Sander W; van der Most, Peter J; van Klinken, Jan B; van Setten, Jessica; Verma, Shefali S; Verweij, Niek; Veturi, Yogasudha; Wang, Carol A; Wang, Chaolong; Wang, Jun-Sing; Wang, Lihua; Wang, Ya Xing; Wang, Zhe; Warren, Helen R; Bin Wei, Wen; Wen, Wanqing; Wheeler, William A; Wickremasinghe, Ananda R; Wielscher, Matthias; Winsvold, Bendik S; Wong, Andrew; Wuttke, Matthias; Xia, Rui; Yamamoto, Ken; Yang, Jingyun; Yao, Jie; Young, Hannah; Yousri, Noha A; Yu, Lei; Zeng, Lingyao; Zhang, Weihua; Zhang, Xinyuan; Zhao, Jing-Hua; Zhao, Wei; Zhou, Wei; Zimmermann, Martina E; Zoledziewska, Magdalena; 't Hart, Leen M; Adair, Linda S; Adams, Hieab HH; Aguilar-Salinas, Carlos A; Al-Mulla, Fahd; Arnett, Donna K; Asselbergs, Folkert W; Åsvold, Bjørn Olav; Attia, John; Banas, Bernhard; Bandinelli, Stefania; Beilin, Lawrence J; Bennett, David A; Bergler, Tobias; Bharadwaj, Dwaipayan; Biino, Ginevra; Boerwinkle, Eric; Böger, Carsten A; Borja, Judith B; Bouchard, Claude; Bowden, Donald W; Brandslund, Ivan; Brumpton, Ben; Buring, Julie E; Caulfield, Mark J; Chambers, John C; Chandak, Giriraj R; Chanock, Stephen J; Chaturvedi, Nish; Ida Chen, Yii-Der; Chen, Zhengming; Cheng, Ching-Yu; Cho, Yoon Shin; Christensen, Kaare; Christophersen, Ingrid E; Ciullo, Marina; Cole, John W; Collins, Francis S; Concas, Maria Pina; Cooper, Richard S; Cruz, Miguel; Cucca, Francesco; Cutler, Michael J; Damrauer, Scott M; Dantoft, Thomas M; de Borst, Gert J; de Geus, Eco JC; de Groot, Lisette CPGM; De Jager, Philip L; de Kleijn, Dominique PV; de Silva, H Janaka; Dedoussis, George V; den Hollander, Anneke I; Du, Shufa; Easton, Douglas F; Eckardt, Kai-Uwe; Elders, Petra JM; Eliassen, A Heather; Ellinor, Patrick T; Elmståhl, Sölve; Erdmann, Jeanette; Evans, Michele K; Fatkin, Diane; Feenstra, Bjarke; Feitosa, Mary F; Ferrucci, Luigi; Florez, Jose C; Ford, Ian; Fornage, Myriam; Franke, Andre; Franks, Paul W; Freedman, Barry I; Gieger, Christian; Girotto, Giorgia; Golightly, Yvonne M; Gonzalez-Villalpando, Clicerio; Gordon-Larsen, Penny; Grallert, Harald; Grant, Struan FA; Grarup, Niels; Griffiths, Lyn; Gudnason, Vilmundur; Haiman, Christopher; Hakonarson, Hakon; Hansen, Torben; Hartman, Catharina A; Hattersley, Andrew T; Hayward, Caroline; Heid, Iris M; Heng, Chew-Kiat; Hengstenberg, Christian; Herzig, Karl-Heinz; Hewitt, Alex W; Hishigaki, Haretsugu; Hougaard, David M; Hoyng, Carel B; Huang, Paul L; Huang, Wei; Huang, Wen-Yi; Huffman, Jennifer E; Hunt, Steven C; Hutri, Nina; Hveem, Kristian; Hyppönen, Elina; Iacono, William G; Ichihara, Sahoko; Ikram, M Arfan; Isasi, Carmen R; Jarvelin, Marjo-Riitta; Jin, Zi-Bing; Jöckel, Karl-Heinz; Jonas, Jost B; Joshi, Peter K; Jousilahti, Pekka; Jukema, J Wouter; Kähönen, Mika; Kamatani, Yoichiro; Kang, Kui Dong; Kaprio, Jaakko; Kardia, Sharon LR; Karpe, Fredrik; Kato, Norihiro; Kavousi, Maryam; Kee, Frank; Kessler, Thorsten; Khera, Amit V; Khor, Chiea Chuen; Kiemeney, Lambertus ALM; Kim, Bong-Jo; Kim, Eung Kweon; Kim, Hyung-Lae; Kirchhof, Paulus; Kivimaki, Mika; Koh, Woon-Puay; Koistinen, Heikki A; Kokkinos, Alexander; Kooner, Jaspal S; Kooperberg, Charles; Kovacs, Peter; Kraaijeveld, Adriaan; Kraft, Peter; Krauss, Ronald M; Kumari, Meena; Kutalik, Zoltan; Laakso, Markku; Lange, Leslie A; Langenberg, Claudia; Launer, Lenore J; Lee, Hyejin; Lee, Nanette R; Lehtimäki, Terho; Lemaitre, Rozenn N; Li, Huaixing; Li, Liming; Lieb, Wolfgang; Lin, Xu; Lind, Lars; Linneberg, Allan; Liu, Ching-Ti; Liu, Jianjun; Loeffler, Markus; London, Barry; Lu, Fan; Lubitz, Steven A; Mackey, David A; Magnusson, Patrik KE; Manson, JoAnn E; Marcus, Gregory M; Marques Vidal, Pedro; Martin, Nicholas G; März, Winfried; Matsuda, Fumihiko; McCarthy, Mark I; McGarrah, Robert W; McGue, Matt; McKnight, Amy Jayne; Medland, Sarah E; Mellström, Dan; Metspalu, Andres; Mitchell, Braxton D; Mitchell, Paul; Mook-Kanamori, Dennis O; Mori, Trevor A; Morris, Andrew D; Mucci, Lorelei A; Munroe, Patricia B; Nalls, Mike A; Nazarian, Saman; Nelson, Amanda E; Neville, Matt J; Newton-Cheh, Christopher; Nielsen, Christopher S; Niinikoski, Harri; Nikus, Kjell; Nöthen, Markus M; Ogunniyi, Adesola; Ohlsson, Claes; Oldehinkel, Albertine J; Orozco, Lorena; Pahkala, Katja; Pajukanta, Päivi; Palmer, Colin NA; Parra, Esteban J; Pattaro, Cristian; Pedersen, Oluf; Pennell, Craig E; Penninx, Brenda WJH; Perusse, Louis; Peters, Annette; Peyser, Patricia A; Porteous, David J; Posthuma, Danielle; Power, Chris; Pramstaller, Peter P; Province, Michael A; Psaty, Bruce M; Qi, Qibin; Qu, Jia; Rader, Daniel J; Raitakari, Olli T; Rallidis, Loukianos S; Rao, Dabeeru C; Redline, Susan; Reilly, Dermot F; Reiner, Alexander P; Rhee, Sang Youl; Ridker, Paul M; Rienstra, Michiel; Ripatti, Samuli; Ritchie, Marylyn D; Rivadeneira, Fernando; Roden, Dan M; Rosendaal, Frits R; Rotter, Jerome I; Rudan, Igor; Rutters, Femke; Ryu, Seungho; Sabanayagam, Charumathi; Salako, Babatunde; Saleheen, Danish; Salomaa, Veikko; Samani, Nilesh J; Sanghera, Dharambir K; Sattar, Naveed; Schmidt, Börge; Schmidt, Helena; Schmidt, Reinhold; Schulze, Matthias B; Schunkert, Heribert; Scott, Laura J; Scott, Rodney J; Sever, Peter; Sheu, Wayne HH; Shoemaker, M Benjamin; Shu, Xiao-Ou; Simonsick, Eleanor M; Sims, Mario; Singleton, Andrew B; Sinner, Moritz F; Smith, J Gustav; Snieder, Harold; Spector, Tim D; Spedicati, Beatrice; Stampfer, Meir J; Stark, Klaus J; Strachan, David P; Tabara, Yasuharu; Tai, E Shyong; Tang, Hua; Tardif, Jean-Claude; Thanaraj, Thangavel A; Tönjes, Anke; Tuomi, Tiinamaija; Tuomilehto, Jaakko; Tusié-Luna, Maria-Teresa; van Dam, Rob M; van der Harst, Pim; Van der Velde, Nathalie; van Duijn, Cornelia M; van Schoor, Natasja M; Vitart, Veronique; Vohl, Marie-Claude; Völker, Uwe; Vollenweider, Peter; Völzke, Henry; Vrieze, Scott; Wacher-Rodarte, Niels H; Walker, Mark; Wander, Gurpreet S; Wareham, Nicholas J; Watanabe, Richard M; Watkins, Hugh; Weir, David R; Werge, Thomas M; Widen, Elisabeth; Willemsen, Gonneke; Willett, Walter C; Wilson, James F; Wilson, Peter WF; Wong, Tien Y; Woo, Jeong-Taek; Wright, Alan F; Xu, Huichun; Yajnik, Chittaranjan S; Yang, Jian; Yokota, Mitsuhiro; Yuan, Jian-Min; Zeggini, Eleftheria; Zemel, Babette S; Zheng, Wei; Zhu, Xiaofeng; Zillikens, M Carola; Zonderman, Alan B; Zwart, John-Anker; 23andMe Research Team; DiscovEHR (DiscovEHR and MyCode Community Health Initiative); eMERGE (Electronic Medical Records and Genomics Network); GPC-UGR; PRACTICAL Consortium; Understanding Society Scientific Group; VA Million Veteran Program; Abecasis, Goncalo R; Assimes, Themistocles L; Auton, Adam; Boehnke, Michael; Chasman, Daniel I; Esko, Tõnu; Stefansson, Kari; Lettre, Guillaume; Lindgren, Cecilia M; Ng, Maggie CY; O'Donnell, Christopher J; Thorsteinsdottir, Unnur; Visscher, Peter M; Walters, Robin G; Winkler, Thomas W; Wood, Andrew R; Deloukas, Panos; Frayling, Timothy M; Justice, Anne E; Kilpeläinen, Tuomas O; Locke, Adam E; Mohlke, Karen L; North, Kari E; Okada, Yukinori; Willer, Cristen J; Young, Kristin L; Fatumo, Segun; McCaffery, Jeanne M; Timpson, Nicholas J; Hirschhorn, Joel N; Sun, Yan V; Berndt, Sonja I; and Loos, Ruth JF
(2025)
Polygenic prediction of body mass index and obesity through the life course and across ancestries.
Nature medicine.
ISSN 1078-8956
DOI: 10.1038/s41591-025-03827-z
; Yin, Xianyong; Christiansen, Malene R; Yengo, Loic; Preuss, Michael H; Nakabuye, Mariam; Rocheleau, Ghislain; +624 more...Graham, Sarah E; Buchanan, Victoria L; Chittoor, Geetha; Graff, Marielisa; Guindo-Martínez, Marta; Lu, Yingchang; Marouli, Eirini; Sakaue, Saori; Spracklen, Cassandra N; Vedantam, Sailaja; Wilson, Emma P; Chen, Shyh-Huei; Ferreira, Teresa; Ji, Yingjie; Karaderi, Tugce; Lüll, Kreete; Machado, Moara; Malden, Deborah E; Medina-Gomez, Carolina; Moore, Amy; Rüeger, Sina; Akiyama, Masato; Allison, Matthew A; Alvarez, Marcus; Andersen, Mette K; Appadurai, Vivek; Arbeeva, Liubov; Bartell, Eric; Bhaskar, Seema; Bielak, Lawrence F; Bis, Joshua C; Bollepalli, Sailalitha; Bork-Jensen, Jette; Bradfield, Jonathan P; Bradford, Yuki; Brandl, Caroline; Braund, Peter S; Brody, Jennifer A; Broeckel, Ulrich; Burgdorf, Kristoffer S; Cade, Brian E; Cai, Qiuyin; Camarda, Silvia; Campbell, Archie; Cañadas-Garre, Marisa; Chai, Jin-Fang; Chesi, Alessandra; Choi, Seung Hoan; Christofidou, Paraskevi; Couture, Christian; Cuellar-Partida, Gabriel; Danning, Rebecca; Degenhardt, Frauke; Delgado, Graciela E; Delitala, Alessandro; Demirkan, Ayşe; Deng, Xuan; Dietl, Alexander; Dimitriou, Maria; Dimitrov, Latchezar; Dorajoo, Rajkumar; Eichelmann, Fabian; Eliasen, Anders U; Engmann, Jorgen E; Erdos, Michael R; Fairhurst-Hunter, Zammy; Farmaki, Aliki-Eleni; Faul, Jessica D; Fernandez-Lopez, Juan-Carlos; Forer, Lukas; Frank, Mirjam; Freitag-Wolf, Sandra; Fritsche, Lars G; Fuchsberger, Christian; Galesloot, Tessel E; Gao, Yan; Geller, Frank; Giannakopoulou, Olga; Giulianini, Franco; Gjesing, Anette P; Goel, Anuj; Gordon, Scott D; Gorski, Mathias; Grove, Jakob; Guo, Xiuqing; Gustafsson, Stefan; Haessler, Jeffrey; Hansen, Thomas F; Havulinna, Aki S; Haworth, Simon J; Heard-Costa, Nancy; Hemerich, Daiane; Highland, Heather M; Hindy, George; Ho, Yuk-Lam; Hofer, Edith; Holliday, Elizabeth; Horn, Katrin; Hornsby, Whitney E; Hottenga, Jouke-Jan; Huang, Hongyan; Huang, Jie; Huerta-Chagoya, Alicia; Huo, Shaofeng; Hwang, Mi Yeong; Hwu, Chii-Min; Iha, Hiroyuki; Ikeda, Daisuke D; Isono, Masato; Jackson, Anne U; Jansen, Iris E; Jiang, Yunxuan; Johansson, Ingegerd; Jonsson, Anna; Jørgensen, Torben; Kalafati, Ioanna P; Kanai, Masahiro; Kanoni, Stavroula; Kårhus, Line L; Kasturiratne, Anuradhani; Katsuya, Tomohiro; Kawaguchi, Takahisa; Kember, Rachel L; Kentistou, Katherine A; Kim, Daeeun; Kim, Han-Na; Kim, Young Jin; Kleber, Marcus E; Knol, Maria J; Kurbasic, Azra; Lauzon, Marie; Le, Phuong; Lea, Rodney; Lee, Jong-Young; Lee, Wen-Jane; Leonard, Hampton L; Li, Hengtong; Li, Shengchao A; Li, Xiaohui; Li, Xiaoyin; Liang, Jingjing; Lin, Honghuang; Lin, Kuang; Liu, Jun; Liu, Xueping; Lo, Ken Sin; Long, Jirong; Lores-Motta, Laura; Luan, Jian'an; Lyssenko, Valeriya; Lyytikäinen, Leo-Pekka; Mahajan, Anubha; Malik, Md Zubbair; Mamakou, Vasiliki; Mangino, Massimo; Manichaikul, Ani; Marten, Jonathan; Mattheisen, Manuel; McDaid, Aaron F; Mei, Quanshun; Meiselbach, Heike; Melendez, Tori L; Milaneschi, Yuri; Miller, Jason E; Millwood, Iona Y; Mishra, Pashupati P; Mitchell, Ruth E; Møllehave, Line T; Mononen, Nina; Mucha, Sören; Munz, Matthias; Mykkänen, Juha; Nakatochi, Masahiro; Nardone, Giuseppe Giovanni; Nelson, Christopher P; Nethander, Maria; Nho, Chu Won; Nielsen, Aneta A; Nolte, Ilja M; Nongmaithem, Suraj S; Noordam, Raymond; Ntalla, Ioanna; Nutile, Teresa; Pandit, Anita; Pauper, Marc; Petersen, Eva RB; Petersen, Liselotte V; Piluso, Francesco; Polašek, Ozren; Poveda, Alaitz; Pyarajan, Saiju; Raffield, Laura M; Rakugi, Hiromi; Ramirez, Julia; Rasheed, Asif; Raven, Dennis; Rayner, Nigel W; Riveros, Carlos; Rohde, Rebecca; Ruggiero, Daniela; Ruotsalainen, Sanni E; Ryan, Kathleen A; Sabater-Lleal, Maria; Santin, Aurora; Saxena, Richa; Scholz, Markus; Shen, Botong; Shi, Jingchunzi; Shin, Jae Hun; Sidore, Carlo; Sidorenko, Julia; Sim, Xueling; Slieker, Roderick C; Smith, Albert V; Smith, Jennifer A; Smyth, Laura J; Southam, Lorraine; Steinthorsdottir, Valgerdur; Sun, Liang; Takeuchi, Fumihiko; Taylor, Kent D; Tayo, Bamidele O; Tcheandjieu, Catherine; Terzikhan, Natalie; Tesolin, Paola; Teumer, Alexander; Theusch, Elizabeth; Thompson, Deborah J; Thorleifsson, Gudmar; Timmers, Paul RHJ; Trompet, Stella; Turman, Constance; Vaccargiu, Simona; van der Laan, Sander W; van der Most, Peter J; van Klinken, Jan B; van Setten, Jessica; Verma, Shefali S; Verweij, Niek; Veturi, Yogasudha; Wang, Carol A; Wang, Chaolong; Wang, Jun-Sing; Wang, Lihua; Wang, Ya Xing; Wang, Zhe; Warren, Helen R; Bin Wei, Wen; Wen, Wanqing; Wheeler, William A; Wickremasinghe, Ananda R; Wielscher, Matthias; Winsvold, Bendik S; Wong, Andrew; Wuttke, Matthias; Xia, Rui; Yamamoto, Ken; Yang, Jingyun; Yao, Jie; Young, Hannah; Yousri, Noha A; Yu, Lei; Zeng, Lingyao; Zhang, Weihua; Zhang, Xinyuan; Zhao, Jing-Hua; Zhao, Wei; Zhou, Wei; Zimmermann, Martina E; Zoledziewska, Magdalena; 't Hart, Leen M; Adair, Linda S; Adams, Hieab HH; Aguilar-Salinas, Carlos A; Al-Mulla, Fahd; Arnett, Donna K; Asselbergs, Folkert W; Åsvold, Bjørn Olav; Attia, John; Banas, Bernhard; Bandinelli, Stefania; Beilin, Lawrence J; Bennett, David A; Bergler, Tobias; Bharadwaj, Dwaipayan; Biino, Ginevra; Boerwinkle, Eric; Böger, Carsten A; Borja, Judith B; Bouchard, Claude; Bowden, Donald W; Brandslund, Ivan; Brumpton, Ben; Buring, Julie E; Caulfield, Mark J; Chambers, John C; Chandak, Giriraj R; Chanock, Stephen J; Chaturvedi, Nish; Ida Chen, Yii-Der; Chen, Zhengming; Cheng, Ching-Yu; Cho, Yoon Shin; Christensen, Kaare; Christophersen, Ingrid E; Ciullo, Marina; Cole, John W; Collins, Francis S; Concas, Maria Pina; Cooper, Richard S; Cruz, Miguel; Cucca, Francesco; Cutler, Michael J; Damrauer, Scott M; Dantoft, Thomas M; de Borst, Gert J; de Geus, Eco JC; de Groot, Lisette CPGM; De Jager, Philip L; de Kleijn, Dominique PV; de Silva, H Janaka; Dedoussis, George V; den Hollander, Anneke I; Du, Shufa; Easton, Douglas F; Eckardt, Kai-Uwe; Elders, Petra JM; Eliassen, A Heather; Ellinor, Patrick T; Elmståhl, Sölve; Erdmann, Jeanette; Evans, Michele K; Fatkin, Diane; Feenstra, Bjarke; Feitosa, Mary F; Ferrucci, Luigi; Florez, Jose C; Ford, Ian; Fornage, Myriam; Franke, Andre; Franks, Paul W; Freedman, Barry I; Gieger, Christian; Girotto, Giorgia; Golightly, Yvonne M; Gonzalez-Villalpando, Clicerio; Gordon-Larsen, Penny; Grallert, Harald; Grant, Struan FA; Grarup, Niels; Griffiths, Lyn; Gudnason, Vilmundur; Haiman, Christopher; Hakonarson, Hakon; Hansen, Torben; Hartman, Catharina A; Hattersley, Andrew T; Hayward, Caroline; Heid, Iris M; Heng, Chew-Kiat; Hengstenberg, Christian; Herzig, Karl-Heinz; Hewitt, Alex W; Hishigaki, Haretsugu; Hougaard, David M; Hoyng, Carel B; Huang, Paul L; Huang, Wei; Huang, Wen-Yi; Huffman, Jennifer E; Hunt, Steven C; Hutri, Nina; Hveem, Kristian; Hyppönen, Elina; Iacono, William G; Ichihara, Sahoko; Ikram, M Arfan; Isasi, Carmen R; Jarvelin, Marjo-Riitta; Jin, Zi-Bing; Jöckel, Karl-Heinz; Jonas, Jost B; Joshi, Peter K; Jousilahti, Pekka; Jukema, J Wouter; Kähönen, Mika; Kamatani, Yoichiro; Kang, Kui Dong; Kaprio, Jaakko; Kardia, Sharon LR; Karpe, Fredrik; Kato, Norihiro; Kavousi, Maryam; Kee, Frank; Kessler, Thorsten; Khera, Amit V; Khor, Chiea Chuen; Kiemeney, Lambertus ALM; Kim, Bong-Jo; Kim, Eung Kweon; Kim, Hyung-Lae; Kirchhof, Paulus; Kivimaki, Mika; Koh, Woon-Puay; Koistinen, Heikki A; Kokkinos, Alexander; Kooner, Jaspal S; Kooperberg, Charles; Kovacs, Peter; Kraaijeveld, Adriaan; Kraft, Peter; Krauss, Ronald M; Kumari, Meena; Kutalik, Zoltan; Laakso, Markku; Lange, Leslie A; Langenberg, Claudia; Launer, Lenore J; Lee, Hyejin; Lee, Nanette R; Lehtimäki, Terho; Lemaitre, Rozenn N; Li, Huaixing; Li, Liming; Lieb, Wolfgang; Lin, Xu; Lind, Lars; Linneberg, Allan; Liu, Ching-Ti; Liu, Jianjun; Loeffler, Markus; London, Barry; Lu, Fan; Lubitz, Steven A; Mackey, David A; Magnusson, Patrik KE; Manson, JoAnn E; Marcus, Gregory M; Marques Vidal, Pedro; Martin, Nicholas G; März, Winfried; Matsuda, Fumihiko; McCarthy, Mark I; McGarrah, Robert W; McGue, Matt; McKnight, Amy Jayne; Medland, Sarah E; Mellström, Dan; Metspalu, Andres; Mitchell, Braxton D; Mitchell, Paul; Mook-Kanamori, Dennis O; Mori, Trevor A; Morris, Andrew D; Mucci, Lorelei A; Munroe, Patricia B; Nalls, Mike A; Nazarian, Saman; Nelson, Amanda E; Neville, Matt J; Newton-Cheh, Christopher; Nielsen, Christopher S; Niinikoski, Harri; Nikus, Kjell; Nöthen, Markus M; Ogunniyi, Adesola; Ohlsson, Claes; Oldehinkel, Albertine J; Orozco, Lorena; Pahkala, Katja; Pajukanta, Päivi; Palmer, Colin NA; Parra, Esteban J; Pattaro, Cristian; Pedersen, Oluf; Pennell, Craig E; Penninx, Brenda WJH; Perusse, Louis; Peters, Annette; Peyser, Patricia A; Porteous, David J; Posthuma, Danielle; Power, Chris; Pramstaller, Peter P; Province, Michael A; Psaty, Bruce M; Qi, Qibin; Qu, Jia; Rader, Daniel J; Raitakari, Olli T; Rallidis, Loukianos S; Rao, Dabeeru C; Redline, Susan; Reilly, Dermot F; Reiner, Alexander P; Rhee, Sang Youl; Ridker, Paul M; Rienstra, Michiel; Ripatti, Samuli; Ritchie, Marylyn D; Rivadeneira, Fernando; Roden, Dan M; Rosendaal, Frits R; 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(2025)
Polygenic prediction of body mass index and obesity through the life course and across ancestries.
Nature medicine.
ISSN 1078-8956
DOI: 10.1038/s41591-025-03827-z
Polygenic scores (PGSs) for body mass index (BMI) may guide early prevention and targeted treatment of obesity. Using genetic data from up to 5.1 million people (4.6% African ancestry, 14.4% American ancestry, 8.4% East Asian ancestry, 71.1% European ancestry and 1.5% South Asian ancestry) from the GIANT consortium and 23andMe, Inc., we developed ancestry-specific and multi-ancestry PGSs. The multi-ancestry score explained 17.6% of BMI variation among UK Biobank participants of European ancestry. For other populations, this ranged from 16% in East Asian-Americans to 2.2% in rural Ugandans. In the ALSPAC study, children with higher PGSs showed accelerated BMI gain from age 2.5 years to adolescence, with earlier adiposity rebound. Adding the PGS to predictors available at birth nearly doubled explained variance for BMI from age 5 onward (for example, from 11% to 21% at age 8). Up to age 5, adding the PGS to early-life BMI improved prediction of BMI at age 18 (for example, from 22% to 35% at age 5). Higher PGSs were associated with greater adult weight gain. In intensive lifestyle intervention trials, individuals with higher PGSs lost modestly more weight in the first year (0.55 kg per s.d.) but were more likely to regain it. Overall, these data show that PGSs have the potential to improve obesity prediction, particularly when implemented early in life.
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picture_as_pdf - Smit-etal-2025-Polygenic-prediction-of-body-mass.pdf
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subject - Published Version
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- Available under Creative Commons: Attribution-NonCommercial-No Derivative Works 4.0
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