Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Placental Infection Is Associated With Massive Perivillous Fibrin Deposition at the Maternal-Fetal Interface: A Preliminary Study.

Esin Kotiloglu-Karaa ; Beatrix Kele ; Raghavendran Kulasegaran-Shylini ; Claire E Broad ORCID logo ; Dola Owoyemi ; Joanne Martin ; Graham MacPhail ; Stamatina Iliodromiti ; Anna Riddell ; Eliza Alexander ; +1 more... Teresa Cutino-Moguel ORCID logo ; (2022) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Placental Infection Is Associated With Massive Perivillous Fibrin Deposition at the Maternal-Fetal Interface: A Preliminary Study. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 75 (1). e1176-e1179. ISSN 1058-4838 DOI: 10.1093/cid/ciac173
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We observed an increased frequency of massive perivillous fibrin deposition (MPFD) during the second coronavirus disease 2019 (COVID-19) pandemic wave dominated by the Alpha variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). MPFD associated with 100% reverse transcription polymerase chain reaction (RT-PCR) positivity for SARS-CoV-2 and detection by immunohistochemistry. The Alpha variant was identified in all placentas with MPFD that could be sequenced.


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