Dengue Infections Among Household Contacts of Symptomatic Index Cases: Implications for Community-Based Intervention Studies
;
Liesbeth
Van Wesenbeeck
;
Martin L
Hibberd
;
Annemie
Buelens
;
Michiko
Toizumi
;
Kim De
Clerck
;
Leen
Vijgen
;
Ole
Lagatie
;
Lucy
Masdin
;
Hien Anh Thi
Nguyen
;
+10 more...
Hoang Huy
Le
;
Duc Anh
Dang
;
Mai Kim
Huynh
;
Lien Thuy
Le
;
Trieu Bao
Nguyên
;
Stephane
Hue
;
Hung Thai
Do
;
Guillermo
Herrera-Taracena
;
Freya
Rasschaert
;
Lay-Myint
Yoshida
;
(2025)
Dengue Infections Among Household Contacts of Symptomatic Index Cases: Implications for Community-Based Intervention Studies.
Viruses, 17 (6).
p. 859.
ISSN 1999-4915
DOI: 10.3390/v17060859
Background: Dengue is a global health concern, with half of the world’s population at risk and no antiviral treatment available. This Phase 0 study investigated dengue infections among household contacts (HHCs) of dengue index cases (ICs) and assessed the feasibility of conducting a Phase 2 trial for a novel antiviral.
Methods: Participants were enrolled in Nha Trang, Vietnam, from April 2022 to February 2023. Dengue ICs were identified within 72 h of fever onset, and their healthy adult HHCs enrolled within 48 h. Blood samples and questionnaires were collected bi-weekly for four weeks, with a follow-up visit on day 40. DENV RT-qPCR, NS1, and anti-DENV IgM/IgG ELISAs were performed.
Results: Overall, 130 dengue ICs and 301 HHCs were enrolled, with 91.7% (276/301) completing all follow-up visits. Baseline anti-DENV IgG showed prior dengue infections in 262/301 HHCs (87.0%). Fifty HHCs were excluded from the HHC infection analysis based on evidence of a DENV infection (viral load [VL], NS1, IgM, and IgG results) at enrollment. During follow-up, 2.0% of HHCs (5/251) had DENV infections based on virological parameters (DENV RNA and/or NS1 positivity), and anti-DENV IgG/IgM seroconversion was detected in 7.2% (18/251).
Conclusions: This study demonstrated the operational feasibility of a dengue IC-HHC design for a Phase 2 trial.
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