Harnessing artificial intelligence for predictive modeling in combating antimicrobial resistance: a call for integration and innovation

Adamu Muhammad Ibrahim ORCID logo ; Mohamed Mustaf Ahmed ORCID logo ; Shuaibu Saidu Musa ORCID logo ; Usman Abubakar Haruna ORCID logo ; Mohammed Raihanatu Hamid ; Ayodele Isaac Adedokun ORCID logo ; Aishat Muhammad Saleh ORCID logo ; Don Lucero-Prisno Eliso ORCID logo ; (2025) Harnessing artificial intelligence for predictive modeling in combating antimicrobial resistance: a call for integration and innovation. BMC Artificial Intelligence, 1 (1). DOI: 10.1186/s44398-025-00001-w
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Antimicrobial resistance (AMR) represents a critical global health challenge with profound socioeconomic and public health implications. The rise of resistant microorganisms undermines the effectiveness of antibiotics, antivirals, antifungals, and other antimicrobial agents, leading to increased mortality, prolonged illnesses, and escalating medical costs. This study underscores the urgent need for innovative solutions, focusing on the integration of artificial intelligence (AI) to combat AMR. AI, with its rapid data processing, predictive modeling capabilities, and cost-effectiveness, emerges as a transformative tool in mitigating this global crisis. AI-driven predictive models have demonstrated remarkable accuracy in identifying AMR patterns by analyzing vast datasets encompassing patient demographics, antibiotic usage, and environmental factors. These models enhance the precision of antibiotic therapy, guide antimicrobial stewardship programs, and provide early warnings for resistance outbreaks. Furthermore, AI facilitates the development of novel antimicrobial agents, accelerates drug discovery, and supports precision medicine by tailoring treatments to individual patients' profiles. The effective application of AI in addressing AMR necessitates interdisciplinary collaboration among healthcare professionals, microbiologists, policymakers, and AI specialists. This paper calls for robust policy frameworks, dedicated funding, and global partnerships to integrate AI into healthcare systems for AMR surveillance, prevention, and control. Embracing AI innovation is pivotal to safeguarding global public health and ensuring a sustainable future free from the threat of antimicrobial resistance.


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