The influence of HIV on body composition and its relationship with physical function in mid-life women: a cross-sectional study from Zimbabwe

<h4>Objective</h4>Menopause-related changes in body composition and physical function are unclear in Southern Africa, particularly in the context of a generalized HIV epidemic with high antiretroviral therapy (ART) coverage.<h4>Method</h4>A total of 263 Zimbabwean women (53% women living with HIV [WLH]) aged 40-60 years provided data on menopause, ART use, anthropometry, body composition (appendicular lean mass [ALM], muscle area, fat mass), handgrip strength (HGS) and gait speed. Linear regression determined relationships between body composition and physical function, unadjusted and age-menopause-adjusted, stratified by HIV status. Univariate logistic regression investigated associations between body composition and self-reported falls.<h4>Results</h4>WLH (96% ART established) were a median (interquartile range) 10.4 (6.4-14.5) years since diagnosis, with lower weight, body mass index, ALM, fat mass and HGS than women living without HIV (WLWOH). With menopause transition, WLH lost weight, ALM, gynoid mass and muscle area (all <i>p</i>-trend <0.05); however, WLWOH did not. Both WLH and WLWOH lost HGS (<i>p</i>-trend <0.05). ALM was positively associated with HGS in all women. In WLH, greater percentage body fat, particularly gynoid fat, was associated with increased odds of falls (1.69 [1.00-2.89], <i>p</i> = 0.049 and 1.72 [1.08-2.75], <i>p</i> = 0.023, respectively).<h4>Conclusion</h4>Women living with HIV were more likely to experience adverse changes in body composition through menopause; fat mass gains were associated with risk of falls.